Pulmonary Arterial Hypertension: A Stem Cell Hypothesis

2015 ◽  
pp. 289-306
Author(s):  
Quentin Felty ◽  
Seiijiro Sakao ◽  
Norbert F. Voelkel
Keyword(s):  
Stem Cell ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Arterial

Pulmonary Arterial Hypertension After Hematopoeitic Stem Cell Transplant

CHEST Journal ◽  
2012 ◽  
Vol 142 (4) ◽  
pp. 118A
Author(s):  
Hala Moukhachen ◽  
Prabalini Rajendram ◽  
Sanjay Chawla ◽  
Nina Raoof ◽  
Kaye Hale ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Stem Cell Transplant ◽  
Cell Transplant ◽  
Pulmonary Arterial

scholarly journals Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension?

2018 ◽  
Vol 19 (9) ◽  
pp. 2534 ◽  
Author(s):  
Gareth Willis ◽  
Angeles Fernandez-Gonzalez ◽  
Monica Reis ◽  
S. Mitsialis ◽  
Stella Kourembanas
Keyword(s):  
Stem Cell ◽  
Pulmonary Arterial Hypertension ◽  
Mesenchymal Stem Cell ◽  
Arterial Hypertension ◽  
Pulmonary Inflammation ◽  
Pulmonary Arteries ◽  
Cross Sectional ◽  
Macrophage Function ◽  
Beneficial Effects ◽  
Pulmonary Arterial

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by remodeling of the pulmonary arteries, increased pulmonary infiltrates, loss of vascular cross-sectional area, and elevated pulmonary vascular resistance. Despite recent advances in the management of PAH, there is a pressing need for the development of new tools to effectively treat and reduce the risk of further complications. Dysregulated immunity underlies the development of PAH, and macrophages orchestrate both the initiation and resolution of pulmonary inflammation, thus, manipulation of lung macrophage function represents an attractive target for emerging immunomodulatory therapies, including cell-based approaches. Indeed, mesenchymal stem cell (MSC)-based therapies have shown promise, effectively modulating the macrophage fulcrum to favor an anti-inflammatory, pro-resolving phenotype, which is associated with both histological and functional benefits in preclinical models of pulmonary hypertension (PH). The complex interplay between immune system homeostasis and MSCs remains incompletely understood. Here, we highlight the importance of macrophage function in models of PH and summarize the development of MSC-based therapies, focusing on the significance of MSC exosomes (MEx) and the immunomodulatory and homeostatic mechanisms by which such therapies may afford their beneficial effects.

scholarly journals WHAT KIND OF MESENCHYMAL STEM CELL IS PROMISING IN THE PREVENTION OF PULMONARY ARTERIAL HYPERTENSION IN A MURINE MODEL?

2017 ◽  
Vol 69 (11) ◽  
pp. 1883
Author(s):  
Seungbum Choi ◽  
Seyeon Oh ◽  
Sehyun Chae ◽  
Jeongsik Moon ◽  
Kyung-Hee Kim ◽  
...  
Keyword(s):  
Stem Cell ◽  
Pulmonary Arterial Hypertension ◽  
Mesenchymal Stem Cell ◽  
Arterial Hypertension ◽  
Murine Model ◽  
Pulmonary Arterial
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