Apolipoprotein Mimetics in the Amelioration of Respiratory Inflammation

2015 ◽  
pp. 89-98
Author(s):  
Kirkwood A. Pritchard
Keyword(s):  
Respiratory Inflammation

Attenuated Asthma Phenotype in Mice With a Fetal-Like Antigen Receptor Repertoires

2021 ◽  
Author(s):  
Regine Stutz ◽  
Christopher Meyer ◽  
Elisabeth Kaiser ◽  
Sybelle Goedicke-Fritz ◽  
Harry Schroeder ◽  
...  
Keyword(s):  
Antigen Receptor ◽  
Allergic Airway Inflammation ◽  
Cell Receptor ◽  
Lung Function Test ◽  
Antigen Receptors ◽  
Asthma Phenotype ◽  
Receptor Repertoire ◽  
Repertoire Diversity ◽  
Cytokine Milieu ◽  
Respiratory Inflammation

Abstract We hypothesized that the scarcity of N-nucleotides might contribute to the inability of the neonate to mount a robust allergic immune response. To test this, we used terminal deoxyribunucleotidyl Transferase deficient (TdT-/-) mice, which express “fetal like” T cell receptor and immunoglobulin repertoires with largely germline-encoded CDR3 regions.Intraperitoneal sensitization was followed by aerosol provocation with either PBS or the allergen OVA in both Tdt-/- mice and wild-type mice to develop allergic respiratory inflammation. The effects of this procedure were investigated by lung function test, immunological analysis of serum and brochoalveolar lavage. The local TH2 cytokine milieu was significantly attenuated in Tdt-/- mice. Within this group, the induction of total IgE levels was also significantly reduced after sensitization. Tdt-/- mice showed a reduced eosinophilic inflow into the bronchial tubes, which was associated with the elimination of respiratory hyperreactivity. In conclusion, in a murine model of allergic airway inflammation, the expression of fetal-like antigen receptors was associated with a reduced ability to mount an asthma phenotype. This underlines the importance of somatically-generated antigen-receptor repertoire diversity in type one allergic immune responses and suggests that the fetus may be protected from allergic responses, at least in part, by controlling N addition.

E-selectin as a prognostic factor of patients who hospitalized for respiratory inflammation diseases; a single institutional study

2016 ◽  
Author(s):  
Masamichi Sato ◽  
Yoko Shibata ◽  
Sumito Inoue ◽  
Akira Igarashi ◽  
Yoshikane Tokairin ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Respiratory Inflammation

scholarly journals Inhibition by telithromycin of systemic and respiratory inflammation induced by endotoxin in mice

Critical Care ◽  
2007 ◽  
Vol 11 (Suppl 4) ◽  
pp. P28
Author(s):  
Magdalena Leiva ◽  
Alfonso Ruiz-Bravo ◽  
Maria Valera
Keyword(s):  
Respiratory Inflammation

scholarly journals Impact of lung disease on respiratory impedance in young children with cystic fibrosis

2015 ◽  
Vol 46 (6) ◽  
pp. 1672-1679 ◽  
Author(s):  
Kathryn A. Ramsey ◽  
Sarath C. Ranganathan ◽  
Catherine L. Gangell ◽  
Lidija Turkovic ◽  
Judy Park ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Preschool Children ◽  
Lung Disease ◽  
Forced Oscillation ◽  
Forced Oscillation Technique ◽  
Respiratory Resistance ◽  
Lung Abnormalities ◽  
Respiratory Inflammation ◽  
Function Testing ◽  
Tomography Scan

This study aimed to evaluate the ability of the forced oscillation technique (FOT) to detect underlying lung disease in preschool children with cystic fibrosis (CF) diagnosed following newborn screening.184 children (aged 3–6 years) with CF underwent lung function testing on 422 occasions using the FOT to assess respiratory resistance and reactance at the time of their annual bronchoalveolar lavage collection and chest computed tomography scan. We examined associations between FOT outcomes and the presence and progression of respiratory inflammation, infection and structural lung disease.Children with CF who had pronounced respiratory disease, including free neutrophil elastase activity, infection with pro-inflammatory pathogens and structural lung abnormalities had similar FOT outcomes to those children without detectable lung disease. In addition, the progression of lung disease over 1 year was not associated with worsening FOT outcomes.We conclude that the forced oscillation technique is relatively insensitive to detect underlying lung disease in preschool children with CF. However, FOT may still be of value in improving our understanding of the physiological changes associated with early CF lung disease.

Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation

2004 ◽  
Vol 385 (11) ◽  
Author(s):  
Tatsuya Okamoto ◽  
Teruo Akuta ◽  
Fumio Tamura ◽  
Albert van Der Vliet ◽  
Takaaki Akaike
Keyword(s):  
Matrix Metalloproteinases ◽  
Molecular Mechanism ◽  
Bacterial Infections ◽  
Respiratory Inflammation

Respiratory Inflammation Among Workers Exposed to Airborne Dust With Endotoxins in a Coffee Curing Factory

2012 ◽  
Vol 54 (7) ◽  
pp. 847-850 ◽  
Author(s):  
Bente E. Moen ◽  
Gloria Sakwari ◽  
Simon H. D. Mamuya ◽  
Akwilina V. Kayumba ◽  
Lennart Larsson ◽  
...  
Keyword(s):  
Airborne Dust ◽  
Respiratory Inflammation
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