Modelling the Presence of Diffuse Axonal Injury in Primary Phase Blast-Induced Traumatic Brain Injury

2016 ◽  
pp. 195-203
Author(s):  
Matthew Sinclair ◽  
Adam Wittek ◽  
Barry Doyle ◽  
Karol Miller ◽  
Grand R. Joldes
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Primary Phase

Genu of corpus callosum in diffuse axonal injury induces a worse 1-year outcome in patients with traumatic brain injury

2011 ◽  
Vol 153 (8) ◽  
pp. 1687-1694 ◽  
Author(s):  
Hidetoshi Matsukawa ◽  
Masaki Shinoda ◽  
Motoharu Fujii ◽  
Osamu Takahashi ◽  
Daisuke Yamamoto ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Corpus Callosum ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

281 Predicting neurodegeneration after traumatic brain injury

2018 ◽  
Vol 89 (10) ◽  
pp. A42.1-A42
Author(s):  
Graham Neil SN ◽  
Jolly Amy E ◽  
Bourke Niall J ◽  
Scott Gregory ◽  
Cole James H ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
White Matter ◽  
Brain Atrophy ◽  
Diffusion Tensor ◽  
Chronic Traumatic Encephalopathy ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Jacobian Determinant ◽  
Post Injury

BackgroundDementia rates are elevated after traumatic brain injury (TBI) and a subgroup develops chronic traumatic encephalopathy. Post-traumatic neurodegeneration can be measured by brain atrophy rates derived from neuroimaging, but it is unclear how atrophy relates to the initial pattern of injury.ObjectivesTo investigate the relationship between baseline TBI patterns and subsequent neurodegeneration measured by progressive brain atrophy.Methods55 patients after moderate-severe TBI (mean 3 years post-injury) and 20 controls underwent longitudinal MRI. Brain atrophy was quantified using the Jacobian determinant defined from volumetric T1 scans approximately one year apart. Diffuse axonal injury was measured using diffusion tensor imaging and focal injuries defined from T1 and FLAIR. Neuropsychological assessment was performed.ResultsAbnormal progressive brain atrophy was seen after TBI (~1.8%/year in white matter). This was accompanied by widespread reductions in fractional anisotropy, in keeping with the presence of diffuse axonal injury. There was a strong negative correlation between FA and brain atrophy, whereby areas of greater white matter damage showed greater atrophy over time.ConclusionsThe results show a strong relationship between the location of diffuse axonal injury and subsequent neurodegeneration. This suggests that TBI triggers progressive neurodegeneration through the long-lasting effects of diffuse axonal injury.

scholarly journals Early intervention combining Chinese and Western medicine in traumatic brain injury with diffuse axonal injury: A report of three cases

2020 ◽  
Vol 10 (5) ◽  
pp. 504-510
Author(s):  
Shuenn-Yun Wu ◽  
Ko-Ying Wen ◽  
Han-Chin Chou ◽  
Shang-Ming Chiu ◽  
Yu-Chang Hou ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Early Intervention ◽  
Brain Injury ◽  
Western Medicine ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

Analysis of Diffuse Axonal Injury Using Diffusion Tensor Imaging in Traumatic Brain Injury Patients

2010 ◽  
Vol 3 (2) ◽  
pp. 111
Author(s):  
Hyung Jong Choi ◽  
Jong-Gu Kang ◽  
Seung Ho Ahn ◽  
Suk Hoon Ohn ◽  
Kwang-Ik Jung ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
Diffusion Tensor ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

Intraventricular Hemorrhage on Initial Computed Tomography as Marker of Diffuse Axonal Injury after Traumatic Brain Injury

2015 ◽  
Vol 32 (5) ◽  
pp. 359-365 ◽  
Author(s):  
Daddy Mata-Mbemba ◽  
Shunji Mugikura ◽  
Atsuhiro Nakagawa ◽  
Takaki Murata ◽  
Yumiko Kato ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Intraventricular Hemorrhage ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

Diffuse axonal injury due to traumatic brain injury alters inhibition of imitative response tendencies

2007 ◽  
Vol 45 (14) ◽  
pp. 3149-3156 ◽  
Author(s):  
Matthias L. Schroeter ◽  
Barbara Ettrich ◽  
Christiane Schwier ◽  
Rainer Scheid ◽  
Thomas Guthke ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

scholarly journals The efficacy of cyclosporine-A on diffuse axonal injury after traumatic brain injury

2014 ◽  
Vol 3 (1) ◽  
pp. 35 ◽  
Author(s):  
SalmanAbbasi Fard ◽  
MajidRezvani Habibabadi ◽  
Payam Moein ◽  
Morteza Naderan ◽  
Rasoul Norouzi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cyclosporine A ◽  
Axonal Injury ◽  
Diffuse Axonal Injury

scholarly journals Intensity Specific Repetitive Mild Traumatic Brain Injury Evokes an Exacerbated Burden of Neocortical Axonal Injury

2018 ◽  
Vol 77 (9) ◽  
pp. 782-792 ◽  
Author(s):  
Yasuaki Ogino ◽  
Michal Vascak ◽  
John T Povlishock
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Neuronal Population ◽  
Electron Microscopic ◽  
Double Labeling ◽  
Repetitive Injury ◽  
Layer V

Abstract Mild traumatic brain injury (mTBI) has been linked to enduring neurological damage following repetitive injury. Previously, we reported that intensity-specific, repetitive mTBI exacerbated microvascular and axonal damage in brainstem. For a more rigorous and global assessment, we assessed the burden of neocortical diffuse axonal injury (DAI) evoked by repetitive mTBI. Mice were subjected to mild central fluid percussion injuries at 1.4 and 1.6 atm with or without repetitive insult at a 3-hour interval and killed at 24 hours postinjury. Neocortical DAI within layer V was quantitatively assessed by double-labeling p-c-Jun and NeuN to identify both the axotomized and total neuronal population. Both confocal and electron microscopic findings revealed no apparent evidence of neuronal death. Repetitive mTBI of 1.6 atm group, but not of 1.4 atm group, demonstrated a significantly higher proportion of axotomized neurons. These results demonstrate that different intensities of mTBI induced different burdens of DAI after repetitive insult. Interestingly, the parallel loss of the righting reflex reflected differences in injury intensity, yet the duration of this reflex was not elongated by the repetitive insult. These data highlight some of the complex issues surrounding repetitive mTBI and its associated morbidity, mandating the need for continued exploration.

scholarly journals The importance of multidisciplinary team in the treatment of severe traumatic brain injury

2020 ◽  
Vol 11 (Vol.11, no.3) ◽  
pp. 368-371
Author(s):  
Corina ROMAN-FILIP ◽  
Maria-Gabriela CATANĂ
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Axonal Injury ◽  
Diffuse Axonal Injury ◽  
Young Patients ◽  
Neurological Status ◽  
The Past ◽  
Precise Representation ◽  
The Times ◽  
The Brain

Noticeable advances have occurred in the field of traumatic brain injury in the past ten years. Brain imagery provides a more precise representation of what occurs in the brain, diffuse axonal injury being an important cause of morbidity and mortality in patients with traumatic brain injury. We present 2 cases that were admitted and discharged from our department. Actually we want to emphasize differences and similarities between the two cases and to highlight different sequelae that traumatic brain injury can do in young patients. Both patients were admitted in a critical state – GCS 4 points and were discharged with an improved neurological status after approximately 30 days. We decided to present these cases to issue a warning about the rehabilitation for these patients which most of the times have a prolonged hospitalization. We wanted to highlight that the rehabilitation does not consist only in the motor part, but in the psychiatric and behaviour part too.

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