Clear Cell Carcinoma, Salivary Glands of

Objective Clear cell carcinoma (CCC) is a rare salivary gland malignancy, believed to be generally low grade. We investigated CCC epidemiology and clinical behavior, using the National Cancer Database (NCDB). Study Design Retrospective cohort study. Setting NCDB. Subjects and Methods All CCCs of the salivary glands were selected between 2004 and 2015. Patient demographics, tumor characteristics, treatments, and survival were analyzed. Cox regression analyses were performed in treated patients. Results We identified 268 patients with CCC. Median age was 61 (21-90) years. Most were female (145, 54%). The most common site was oral cavity (119, 44%), followed by major salivary glands (68, 25%) and oropharynx (41, 15%). Most tumors were low grade (81, 68%) and stages I to II (117, 60.6%). Nodal (36, 17.5%) and distant metastases (6, 2.4%) were rare. Most were treated by surgery alone (134, 50.0%), followed by surgery and radiotherapy (69, 25.7%). Five-year overall survival (OS) was 77.6% (95% CI, 71.4%-84.2%). In univariate analysis, older age, major salivary gland and sinonasal site, stages III to IV, high grade, and positive margins were associated with worse OS. In multivariate analysis, only high tumor grade (hazard ratio [HR], 5.76; 95% CI, 1.39-23.85; P = .02), positive margins (HR, 4.01; 95% CI, 1.20-13.43; P = .02), and age ≥60 years (HR, 3.45; 95% CI, 1.39-8.55; P = .01) were significantly associated with OS. Conclusion We report the largest series of clear cell carcinomas of the head and neck. Outcomes are generally favorable following surgical-based treatments. In this series, pathologic tumor grade is associated with worse survival. Routine evaluation and reporting of tumor grade might better guide physicians in recommending appropriate treatments in this rare malignancy.

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Clear cell carcinoma arising in pleomorphic adenoma of the minor salivary gland

The Journal of Laryngology & Otology ◽

10.1017/s0022215100110096 ◽

1989 ◽

Vol 103 (8) ◽

pp. 789-791 ◽

Cited By ~ 14

Author(s):

Jerzy Klijanienko ◽

Christian Micheau ◽

Guy Schwaab ◽

Patrick Marandas ◽

Sam Friedman

Keyword(s):

Salivary Gland ◽

Cell Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

English Literature ◽

Relevant Literature ◽

Minor Salivary Gland ◽

A Minor

AbstractMalignant change arising in pleomorphic adenoma of the salivary glands is uncommon, with a reported incidence of 2–10 per cent.Only one case where a pleomorphic adenoma became a clear cell carcinoma appears to have been published in the English literature. An additional case of clear cell carcinoma arising in pleomorphic adenoma of a minor salivary gland is reported and the relevant literature discussed.

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A Case of Hyalinizing Clear Cell Carcinoma, So-Called Clear Cell Carcinoma, Not Otherwise Specified, of the Minor Salivary Glands of the Buccal Mucosa

Case Reports in Otolaryngology ◽

10.1155/2015/471693 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Takahiro Yamanishi ◽

Kiwako Kutsuma ◽

Keisuke Masuyama

Keyword(s):

Cell Carcinoma ◽

Salivary Glands ◽

Tumor Cells ◽

Buccal Mucosa ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Glands ◽

Hyalinizing Clear Cell Carcinoma ◽

Not Otherwise Specified ◽

The Right

Hyalinizing clear cell carcinoma (HCCC), so-called clear cell carcinoma, not otherwise specified (CCC (NOS)), of the salivary glands is a rare and low-grade malignant tumor. We report a case of HCCC so-called CCC (NOS) (referred to as HCCC) of the minor salivary gland of the buccal mucosa. A 52-year-old woman had presented with a gradually growing and indolent mass in the right buccal mucosa for about two years. The first biopsy histopathologically suggested the possibility of malignancy derived from the minor salivary glands. A month later, she visited our hospital. The tumor measured approximately 1.5 cm in diameter and was elastic hard, smooth, and well movable. Image examinations demonstrated internal homogeneity of the lesion, which had a smooth margin, in the right buccal mucosa. Complete tumor resection followed by covering with a polyglycolic acid sheet and fibrin glue spray was performed without surgical flap reconstruction. Histopathological findings revealed proliferating tumor cells with clear cytoplasm surrounded by hyalinizing stroma in the submucosal minor salivary glands. Immunohistochemical stains revealed these tumor cells to be positive for epithelial cell markers but negative for myoepithelial ones. These findings confirmed the diagnosis of HCCC. Good wound healing and no evidence of local recurrence and metastasis have been shown since surgery.

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Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

Polish Journal of Pathology ◽

10.5114/pjp.2016.59475 ◽

2016 ◽

Vol 1 ◽

pp. 39-45 ◽

Cited By ~ 6

Author(s):

Hanna Majewska ◽

Alena Skálová ◽

Klaudia Radecka ◽

Dominik Stodulski ◽

Martin Hyrcza ◽

...

Keyword(s):

Cell Carcinoma ◽

Salivary Glands ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Renal Clear Cell Carcinoma ◽

Pathological Study ◽

Carcinoma Metastasis

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Hyalinizing clear cell carcinoma of parotid, intricacies of management:a rare case report

Journal of Surgery and Trauma ◽

10.32592/jsurgery.2021.9.4.106 ◽

2021 ◽

pp. 171-175

Keyword(s):

Cell Carcinoma ◽

Salivary Glands ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Hyalinizing Clear Cell Carcinoma ◽

Insidious Onset ◽

Rare Case Report ◽

Needle Aspiration Cytology

Hyalinizing clear cell carcinoma (HCCC) usually affects minor salivary glands. It rarely occurs in major salivary glands. HCCCis difficult to diagnose in Fine Needle Aspiration cytology (FNAC). The possibility of metastasis from other primary sites should be rejected during the management of these tumors. An elderly manpresented with insidious onset, and gradual progressive painless swelling arising from the deep lobe of the parotid gland. FNAC, which was performedtwice with UltrasoundGuidance(USG), could not provide much detail about the type of tumor. Total conservative parotidectomy was conducted. These rare tumors cause significant challenges to physicians. Thehigh index of suspicion and combined efforts ofthe multidisciplinary team are pivotal in management.

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Hyalinizing clear cell carcinoma of the base of the tongue

The Journal of Laryngology & Otology ◽

10.1258/00222150260293718 ◽

2002 ◽

Vol 116 (10) ◽

pp. 851-853 ◽

Cited By ~ 34

Author(s):

R. Balakrishnan ◽

Dipak Ranjan Nayak ◽

Suresh Pillai ◽

Lakshmi Rao

Keyword(s):

Oral Cavity ◽

Cell Carcinoma ◽

Salivary Glands ◽

Clear Cell ◽

Clear Cell Carcinoma ◽

Minor Salivary Glands ◽

Rare Tumour ◽

Hyalinizing Clear Cell Carcinoma ◽

Epithelial Myoepithelial Carcinoma ◽

Base Of The Tongue

Clear cell carcinoma of the salivary glands is a rare tumour that represents less than one per cent of all salivary tumours. They are divided into a biphasic, epithelial-myoepithelial carcinoma and a monophasic pattern which may be myoepithelial or ductal in origin. The latter is accompanied by prominent fibrohyaline stroma and has been described recently as hyalinizing clear cell carcinoma (HCCC).Most of the HCCC occur in the oral cavity, and are associated with minor salivary glands, unlike the biphasic pattern which is more common in the major salivary glands. In the oral cavity, the commonest site is the palate followed by the lips and the buccal mucosa. Its occurrence in the oropharynx and the larynx is extremely rare.

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