Vitamin C and Bone Health

The interaction between vitamin C and bone health: a narrative review

Expert Review of Precision Medicine and Drug Development ◽

10.1080/23808993.2018.1482211 ◽

2018 ◽

Vol 3 (3) ◽

pp. 215-223

Author(s):

Alberto Falchetti ◽

Roberta Cosso

Keyword(s):

Vitamin C ◽

Bone Health ◽

Narrative Review

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Vitamin C and Bone Health: Evidence from Cell, Animal and Human Studies

Current Drug Targets ◽

10.2174/1389450116666150907100838 ◽

2018 ◽

Vol 19 (5) ◽

pp. 439-450 ◽

Cited By ~ 7

Author(s):

Kok-Yong Chin ◽

Soelaiman Ima-Nirwana

Keyword(s):

Vitamin C ◽

Bone Health ◽

Human Studies

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The Role of Vitamins in the Prevention of Osteoporosis – a Brief Status Report

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831.69.3.194 ◽

1999 ◽

Vol 69 (3) ◽

pp. 194-197 ◽

Cited By ~ 39

Author(s):

Weber

Keyword(s):

Vitamin D ◽

Bone Density ◽

Vitamin C ◽

Vitamin K ◽

Bone Health ◽

Intervention Studies ◽

Epidemiological Studies ◽

Bone Status ◽

Prevention Of Osteoporosis

This papers summarizes the main role vitamins are believed to play in the prevention of osteoporosis, a common disease which is anticipated to rapidly increase because of the aging of the population. Vitamin D, the classical vitamin related to bone health, improves bone strength mainly by increasing intestinal calcium absorption and reabsorption of calcium by the kidney. Several intervention studies demonstrated in humans that vitamin D can improve bone status as measured by bone density. Vitamin C is considered an essential cofactor of collagen formation. Epidemiological studies report a positive association between vitamin C intake and bone density. Intervention studies on the effect of vitamin C on bone status are missing. Vitamin B6 could function as a cofactor to build up cross-links. In humans, however, there is little evidence to support this. Vitamin K is required for the biological activity of several coagulation factors; the classical function of vitamin K. Recent research also points to a role of vitamin K in bone metabolism. Vitamin K mediates the ¨-carboxylation of glutamyl residues on several bone proteins, notably osteocalcin. Epidemiological studies and results from first intervention trials are consistently suggesting that vitamin K may improve bone health.

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