Product Delivery Strategies

2017 ◽  
pp. 11-15
Author(s):  
Gabriel Steinhardt
Keyword(s):  
Product Delivery ◽  
Delivery Strategies

Innovative Drug Delivery Strategies for Topical Photodynamic Therapy using Porphyrin Precursors

2007 ◽  
Vol 26 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Desmond I. J. Morrow ◽  
Martin J. Garland ◽  
Paul A. McCarron ◽  
A. David Woolfson ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Innovative Drug ◽  
Delivery Strategies

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies

The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations

2019 ◽  
Vol 26 (13) ◽  
pp. 2330-2355 ◽  
Author(s):  
Anutthaman Parthasarathy ◽  
Sasikala K. Anandamma ◽  
Karunakaran A. Kalesh
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Therapeutic Potential ◽  
The Past ◽  
Recombinant Production ◽  
Tremendous Progress ◽  
Recent Developments ◽  
Therapeutic Peptides ◽  
Development Processes ◽  
Delivery Strategies

Peptide therapeutics has made tremendous progress in the past decade. Many of the inherent weaknesses of peptides which hampered their development as therapeutics are now more or less effectively tackled with recent scientific and technological advancements in integrated drug discovery settings. These include recent developments in synthetic organic chemistry, high-throughput recombinant production strategies, highresolution analytical methods, high-throughput screening options, ingenious drug delivery strategies and novel formulation preparations. Here, we will briefly describe the key methodologies and strategies used in the therapeutic peptide development processes with selected examples of the most recent developments in the field. The aim of this review is to highlight the viable options a medicinal chemist may consider in order to improve a specific pharmacological property of interest in a peptide lead entity and thereby rationally assess the therapeutic potential this class of molecules possesses while they are traditionally (and incorrectly) considered ‘undruggable’.

scholarly journals Effects of Mesenchymal Stem Cell‐Derived Paracrine Signals and Their Delivery Strategies

2021 ◽  
pp. 2001689
Author(s):  
Calvin Chang ◽  
Jerry Yan ◽  
Zhicheng Yao ◽  
Chi Zhang ◽  
Xiaowei Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Delivery Strategies

scholarly journals Cost of vaccine delivery strategies in low- and middle-income countries during the COVID-19 pandemic

Vaccine ◽  
2021 ◽  
Author(s):  
Christina Banks ◽  
Allison Portnoy ◽  
Flavia Moi ◽  
Laura Boonstoppel ◽  
Logan Brenzel ◽  
...  
Keyword(s):  
Vaccine Delivery ◽  
Middle Income ◽  
Middle Income Countries ◽  
Delivery Strategies ◽  
Low And Middle Income

scholarly journals An expandable approach for design and personalization of digital, just-in-time adaptive interventions

2018 ◽  
Vol 26 (3) ◽  
pp. 198-210 ◽  
Author(s):  
Suat Gonul ◽  
Tuncay Namli ◽  
Sasja Huisman ◽  
Gokce Banu Laleci Erturkmen ◽  
Ismail Hakki Toroslu ◽  
...  
Keyword(s):  
Real Life ◽  
Personal Data ◽  
Just In Time ◽  
Intervention Design ◽  
Intervention Delivery ◽  
Life Conditions ◽  
Triggering Conditions ◽  
Delivery Strategies ◽  
Design Mechanism ◽  
Personalized Intervention

AbstractObjectiveWe aim to deliver a framework with 2 main objectives: 1) facilitating the design of theory-driven, adaptive, digital interventions addressing chronic illnesses or health problems and 2) producing personalized intervention delivery strategies to support self-management by optimizing various intervention components tailored to people’s individual needs, momentary contexts, and psychosocial variables.Materials and MethodsWe propose a template-based digital intervention design mechanism enabling the configuration of evidence-based, just-in-time, adaptive intervention components. The design mechanism incorporates a rule definition language enabling experts to specify triggering conditions for interventions based on momentary and historical contextual/personal data. The framework continuously monitors and processes personal data space and evaluates intervention-triggering conditions. We benefit from reinforcement learning methods to develop personalized intervention delivery strategies with respect to timing, frequency, and type (content) of interventions. To validate the personalization algorithm, we lay out a simulation testbed with 2 personas, differing in their various simulated real-life conditions.ResultsWe evaluate the design mechanism by presenting example intervention definitions based on behavior change taxonomies and clinical guidelines. Furthermore, we provide intervention definitions for a real-world care program targeting diabetes patients. Finally, we validate the personalized delivery mechanism through a set of hypotheses, asserting certain ways of adaptation in the delivery strategy, according to the differences in simulation related to personal preferences, traits, and lifestyle patterns.ConclusionWhile the design mechanism is sufficiently expandable to meet the theoretical and clinical intervention design requirements, the personalization algorithm is capable of adapting intervention delivery strategies for simulated real-life conditions.

Value of High-Quality Logistics: Evidence from a Clash Between SF Express and Alibaba

2020 ◽  
Vol 66 (9) ◽  
pp. 3879-3902 ◽  
Author(s):  
Ruomeng Cui ◽  
Meng Li ◽  
Qiang Li
Keyword(s):  
Operations Management ◽  
Economic Value ◽  
Product Variety ◽  
Star Products ◽  
High Quality ◽  
Long Tail ◽  
Online Retail ◽  
Delivery Service ◽  
Product Delivery ◽  
Identification Strategy

Consumers regard product delivery as an important service component that influences their shopping decisions on online retail platforms. Delivering products to customers in a timely and reliable manner enhances customer experience and companies’ profitability. In this research, we explore the extent to which customers value a high-quality delivery experience when shopping online. Our identification strategy exploits a natural experiment: a clash between SF Express and Alibaba, the largest private logistics service provider with the highest reputation in delivery quality in China and the largest online retail platform in China, respectively. The clash resulted in Alibaba unexpectedly removing SF Express as a shipping option from Alibaba’s retail platform for 42 hours in June 2017. Using a difference-in-differences design, we analyze the market performance of 129,448 representative stock-keeping units on Alibaba to quantify the economic value of a high-quality delivery service to sales, product variety, and logistics rating. We find that the removal of the high-quality delivery option from Alibaba’s retail platform reduced sales by 14.56% during the clash, increased the contribution of long-tail to total sales—sales dispersion—by 3%, but did not impact the variety and logistics rating of sold products. Furthermore, we also identify product characteristics that attenuate the value of high-quality logistics and find that the removal of SF Express is more obstructive for (1) star products as compared with long-tail products because the same star products are likely to be supplied by competing retail platforms that customers can easily switch to, (2) expensive products because customers need a reliable delivery service to protect their valuable items from damage or loss, and (3) less-discounted products because customers are more willing to sacrifice the service quality over a price markdown. This paper was accepted by Victor Martínez-de-Albéniz, operations management.

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