Innovative Drug Delivery Strategies for Topical Photodynamic Therapy using Porphyrin Precursors

2007 ◽  
Vol 26 (2) ◽  
pp. 105-116 ◽  
Author(s):  
Desmond I. J. Morrow ◽  
Martin J. Garland ◽  
Paul A. McCarron ◽  
A. David Woolfson ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Innovative Drug ◽  
Delivery Strategies

Recent Developments and Novel Drug Delivery Strategies for the Treatment of Tuberculosis

2019 ◽  
Vol 12 (3) ◽  
pp. 4524-4530
Author(s):  
Yonas Brhane ◽  
Tesfaye Gabriel ◽  
Tigist Adane ◽  
Yemisrach Negash ◽  
Henok Mulugeta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mycobacterium Tuberculosis Complex ◽  
Drug Resistant ◽  
Tuberculosis Complex ◽  
Innovative Drug ◽  
Recent Developments ◽  
Resistant Strains ◽  
Delivery Strategies ◽  
Drug Resistant Strains ◽  
Novel Drug

Tuberculosis (TB) is a contagious infectious illness caused by species having a place with the Mycobacterium tuberculosis complex. The clinical management of tuberculosis still remains a difficult task. Treatment of TB with anti-tubercular drugs becomes the only option available. Hence, the goals of treatment are ensure cure without relapse, prevent death, impede transmission, and prevent emergence of drug resistant strains. This review describes the latest developments and innovative drug delivery strategies for treatment of TB in order to improve the therapeutic efficacy and reduce toxic effect of anti-tubercular agents and enhance patient compliance with concomitant decrease in drug interaction. Among different novel drug delivery systems Niosomes, Liposomes, Dendrimers, Cyclodextrins, Microencapsulation, Alginates and Hydrogels have been described as new drug delivery strategies of anti-tubercular agents. 

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Development of Innovative Orally Fast Disintegrating Film Dosage Forms: A Review

2012 ◽  
Vol 5 (2) ◽  
pp. 1666-1674 ◽  
Author(s):  
Bibhu Prasad Panda ◽  
N.S Dey ◽  
M.E.B. Rao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Geriatric Patients ◽  
Dosage Forms ◽  
Delivery Systems ◽  
Design And Development ◽  
Innovative Drug ◽  
Potential Benefits ◽  
Pharmaceutical Industries

Over the past few decades, there has been an increased interest for innovative drug delivery systems to improve safety, efficacy and patient compliance, thereby increasing the product patent life cycle. The discovery and development of new chemical entities is not only an expensive but also time consuming affair. Hence the pharmaceutical industries are focusing on the design and development of innovative drug delivery systems for existing drugs. One such delivery system is the fast disintegrating oral film, which has gained popularity among pediatric and geriatric patients. This fast disintegrating film with many potential benefits of a fast disintegrating tablet but devoid of friability and risk of choking is more acceptable to pediatric and geriatric patients. Formulation of fast disintegrating film can be achieved by various techniques, but common methods of preparation include spraying and casting. These film forming techniques use hydrophilic film former in combination with suitable excipients, which allow the film to disintegrate or dissolve quickly in the mouth within a few seconds without the administration of water. In view of the advantages of the fast disintegrating films over the fast disintegrating tablets and other dosage forms, it has the potential for commercial exploitation. The oral film dosage form not only has certain advantages of other fast disintegrating systems but also satisfies the unmet needs of the market. The present review emphasizes on the potential benefits, design and development of robust, stable, and innovative orally fast- disintegrating films and their future scenarios on a global market as a pharmaceutical dosage form.  

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies

Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery

2019 ◽  
Vol 26 (14) ◽  
pp. 2502-2513 ◽  
Author(s):  
Md. Iqbal Hassan Khan ◽  
Xingye An ◽  
Lei Dai ◽  
Hailong Li ◽  
Avik Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carrier ◽  
Drug Loading ◽  
Delivery Systems ◽  
Cancer Drug ◽  
Release Mechanism ◽  
Innovative Drug ◽  
Pharmaceutical Excipients ◽  
Weight Variation

The development of innovative drug delivery systems, versatile to different drug characteristics with better effectiveness and safety, has always been in high demand. Chitosan, an aminopolysaccharide, derived from natural chitin biomass, has received much attention as one of the emerging pharmaceutical excipients and drug delivery entities. Chitosan and its derivatives can be used for direct compression tablets, as disintegrant for controlled release or for improving dissolution. Chitosan has been reported for use in drug delivery system to produce drugs with enhanced muco-adhesiveness, permeation, absorption and bioavailability. Due to filmogenic and ionic properties of chitosan and its derivative(s), drug release mechanism using microsphere technology in hydrogel formulation is particularly relevant to pharmaceutical product development. This review highlights the suitability and future of chitosan in drug delivery with special attention to drug loading and release from chitosan based hydrogels. Extensive studies on the favorable non-toxicity, biocompatibility, biodegradability, solubility and molecular weight variation have made this polymer an attractive candidate for developing novel drug delivery systems including various advanced therapeutic applications such as gene delivery, DNA based drugs, organ specific drug carrier, cancer drug carrier, etc.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

Osteomyelitis: Focus on Conventional Treatments and Innovative Drug Delivery Systems

2020 ◽  
Vol 17 ◽  
Author(s):  
Marina Gallarate ◽  
Daniela Chirio ◽  
Giulia Chindamo ◽  
Elena Peira ◽  
Simona Sapino
Keyword(s):  
Drug Delivery ◽  
Intravenous Administration ◽  
Drug Delivery Systems ◽  
Maxillofacial Surgery ◽  
Microvascular Disease ◽  
Delivery Systems ◽  
Innovative Drug ◽  
Vascular Insufficiency ◽  
Current Therapies ◽  
The Third World

: Osteomyelitis is a bone marrow infection which generally involves cortical plates and which may occur after bone trauma, orthopedic/maxillofacial surgery or after vascular insufficiency episodes. It mostly affects people from the Third World Countries, elderly and patients affected by systemic diseases e.g. autoimmune disorders, AIDS, osteoporosis and microvascular disease. The highest percentage of osteomyelitis cases (almost 75%) is caused by Staphylococcus spp., and in particular by Staphylococcus aureus (more than 50%). The ideal classification and the diagnosis of osteomyelitis are two important tools which help the physicians to choose the best therapeutic strategies. Currently, common therapies provide an extensive debridement in association with intravenous administration of antibiotics (penicillin or clindamycin, vancomycin and fluoroquinolones among all for resistant microorganisms), to avoid the formation of sequestra. However, conventional therapeutic approach involves several drawbacks like low concentration of antibiotic in the infected site, which can lead to resistance and adverse effects due to the intravenous administration. For these reasons, in the last years several studies have been focused on the development of drug delivery systems such as cement, beads, scaffold and ceramics made of hydroxyapatite (HA), calcium phosphate (CaP) and β-tricalcium phosphate (β-TCP) which demonstrated to be biocompatible, poorly toxic and capable to allow osteointegration and a prolonged drug release. The aim of this review is to provide a focus on current therapies and latest developed drug delivery systems with particular attention on those based on CaP and its derivatives, hoping that this work could allow further direction in the field of osteomyelitis.

Researches on Preparation of Photosan Loaded Magnetic Silica Anoparticles and their Anti-Tumor Effects in Photodynamic Therapy

2012 ◽  
Vol 622-623 ◽  
pp. 821-826
Author(s):  
Yu Wen ◽  
Xiao Feng Deng ◽  
Liang Liang Liu ◽  
Shu Yun Shi ◽  
Li Xiong
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sol Gel ◽  
Haematoporphyrin Derivative ◽  
X Ray Diffraction ◽  
Transmission Electron ◽  
Good Biocompatibility ◽  
Low Solubility

Photodynamic therapy (PDT) is an effective, noninvasive and nontoxic therapeutics for cancer and some other diseases. It is becoming a alternative of traditional therapeutics for cancers. But the efficacy of PDT was restricted by insufficient selectivity and low solubility. In this study, novel multifunctional silica-based magnetic nanoparticles were prepared as targeting drug delivery system to achieve higher specificity and better solubility. Haematoporphyrin derivative (photosan) was used as photosensitizer. Magnetite nanoparticles (Fe3O4) and photosan were incorporated in silica nanoparticles by microemulsion and sol-gel methods. The prepared nanoparticles were characterized by X-ray diffraction, and transmission electron microscopy. The nanoparticles possessed good biocompatibility and could cause remarkable photodynamic anti-tumor effects. These suggested that photosan-Fe3O4 nanoparticles had great potential as effective drug delivery system in targeting photodynamic therapy.

Current challenges and emerging drug delivery strategies for the treatment of psoriasis

2016 ◽  
Vol 13 (10) ◽  
pp. 1461-1473 ◽  
Author(s):  
Melissa B. Hoffman ◽  
Dane Hill ◽  
Steven R. Feldman
Keyword(s):  
Drug Delivery ◽  
Delivery Strategies
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