DNA Methylation: A Mediator Between Parenting Stress and Adverse Child Development?

Author(s):  
Rosa H. Mulder ◽  
Jolien Rijlaarsdam ◽  
Marinus H. Van IJzendoorn
2021 ◽  
Vol 274 ◽  
pp. 116511
Author(s):  
Kuan-Chih Chiu ◽  
Fran Sisca ◽  
Jen-Hao Ying ◽  
Wan-Ju Tsai ◽  
Wu-Shiun Hsieh ◽  
...  

2017 ◽  
Vol 1 (6) ◽  
pp. 328-333 ◽  
Author(s):  
Michelle L. Wright ◽  
Yunfeng Huang ◽  
Qin Hui ◽  
Kevin Newhall ◽  
Cindy Crusto ◽  
...  

IntroductionGeneral life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described. The purpose of this study was to examine the relationship between maternal parenting stress and DNA methylation among African Ancestry mother-child dyads.MethodsWe evaluated epigenome-wide DNA methylation relative to parenting stress in 74 mother-child dyads using linear mixed models.ResultsSignificant variation in maternal DNA methylation at 95 CpG sites was associated with level of parenting stress. Notably, we identified a change in DNA methylation associated with poly (ADP-ribose) polymerase-1, which plays a key role in stress signaling. We did not identify any significant variation in child DNA methylation related to maternal parenting stress.ConclusionsHowever, DNA methylation patterns observed in children mirrored patterns observed in their mothers. The results suggest that differential maternal DNA methylation is associated with higher levels of parenting stress.


NHSA Dialog ◽  
2007 ◽  
Vol 10 (1) ◽  
pp. 6-19 ◽  
Author(s):  
Harolyn M. E. Belcher ◽  
Katara Watkins ◽  
Elizabeth Johnson ◽  
Nicholas Ialongo

2021 ◽  
Vol 147 ◽  
pp. 106321
Author(s):  
Andrea Cediel Ulloa ◽  
Anda Gliga ◽  
Tanzy M. Love ◽  
Daniela Pineda ◽  
Daniel W. Mruzek ◽  
...  

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