Abstract. Soil erosion by water is affecting natural and anthropogenic environments through its impacts on water quality and availability, loss of soil nutrients, flood risk, sedimentation in rivers and streams, and damage to civil infrastructure. Sustainable management aims to avoid, reduce and reverse soil erosion and can provide multiple benefits for the environment, population, and livelihoods. We conducted a systematic review of 121 case studies from the Andes to answer the following questions: (1) Which erosion indicators allow us to assess the effectiveness of natural infrastructure? (2) What is the overall impact of working with natural infrastructure on on-site and off-site erosion mitigation? and (3) Which locations and types of studies are needed to fill critical gaps in knowledge and research? Three major categories of natural infrastructure were considered: protective vegetation, soil and water conservation measures, and adaptation measures that regulate the flow and transport of water. From the suite of physical, chemical and biological indicators commonly used in soil erosion research, two indicators were particularly relevant: soil organic carbon (SOC) of topsoil, and soil loss rates at the plot scale. In areas with protective vegetation and/or soil and water conservation measures, the SOC of topsoil is –on average– 1.3 to 2.8 times higher than in areas under traditional agriculture. Soil loss rates in areas with natural infrastructure were reported to be 38 % to 54 % lower than rates measured in untreated croplands. Further research is needed to evaluate whether the reported effectiveness holds during extreme events related to, for example, El Niño–Southern Oscillation.