Air pollution is one of the most important environmental issues that annual causes to mortality large number of people around the world. So, investigating, measuring, and predicting the concentrations of different pollutants in various areas play an important role in preventing the production of this pollutant sand planning to reduce them by people and relevant authorities. One of the new models that play an important role in measuring and predicting pollution is artificial neural network or regression methods. Therefore, this study is trying to predict air pollution in Yasouj by using artificial neural network in 2014. Because the evidences showed that Yasouj due to uncontrolled growth of industrial and urban transport is subject to various air pollutants such as carbon monoxide and particulate matter. Overall, the results of the assessment and prediction of concentration of pollutants of Yasouj by artificial neural network showed that sigmoid transfer function to the hyperbolic tangent function is more efficient in measuring the concentration of pollutants.