A Generic Framework for Computing Parameters of Sequence-Based Dynamic Graphs

Author(s):  
Arnaud Casteigts ◽  
Ralf Klasing ◽  
Yessin M. Neggaz ◽  
Joseph G. Peters
2021 ◽  
Author(s):  
Parsoa Khorsand ◽  
Fereydoun Hormozdiari

Abstract Large scale catalogs of common genetic variants (including indels and structural variants) are being created using data from second and third generation whole-genome sequencing technologies. However, the genotyping of these variants in newly sequenced samples is a nontrivial task that requires extensive computational resources. Furthermore, current approaches are mostly limited to only specific types of variants and are generally prone to various errors and ambiguities when genotyping complex events. We are proposing an ultra-efficient approach for genotyping any type of structural variation that is not limited by the shortcomings and complexities of current mapping-based approaches. Our method Nebula utilizes the changes in the count of k-mers to predict the genotype of structural variants. We have shown that not only Nebula is an order of magnitude faster than mapping based approaches for genotyping structural variants, but also has comparable accuracy to state-of-the-art approaches. Furthermore, Nebula is a generic framework not limited to any specific type of event. Nebula is publicly available at https://github.com/Parsoa/Nebula.


Author(s):  
Mohammad Istiak Hossain ◽  
Jan I. Markendahl

AbstractSmall-scale commercial rollouts of Cellular-IoT (C-IoT) networks have started globally since last year. However, among the plethora of low power wide area network (LPWAN) technologies, the cost-effectiveness of C-IoT is not certain for IoT service providers, small and greenfield operators. Today, there is no known public framework for the feasibility analysis of IoT communication technologies. Hence, this paper first presents a generic framework to assess the cost structure of cellular and non-cellular LPWAN technologies. Then, we applied the framework in eight deployment scenarios to analyze the prospect of LPWAN technologies like Sigfox, LoRaWAN, NB-IoT, LTE-M, and EC-GSM. We consider the inter-technology interference impact on LoRaWAN and Sigfox scalability. Our results validate that a large rollout with a single technology is not cost-efficient. Also, our analysis suggests the rollout possibility of an IoT communication Technology may not be linear to cost-efficiency.


2021 ◽  
Vol 15 (3) ◽  
pp. 1-35
Author(s):  
Muhammad Anis Uddin Nasir ◽  
Cigdem Aslay ◽  
Gianmarco De Francisci Morales ◽  
Matteo Riondato

“Perhaps he could dance first and think afterwards, if it isn’t too much to ask him.” S. Beckett, Waiting for Godot Given a labeled graph, the collection of -vertex induced connected subgraph patterns that appear in the graph more frequently than a user-specified minimum threshold provides a compact summary of the characteristics of the graph, and finds applications ranging from biology to network science. However, finding these patterns is challenging, even more so for dynamic graphs that evolve over time, due to the streaming nature of the input and the exponential time complexity of the problem. We study this task in both incremental and fully-dynamic streaming settings, where arbitrary edges can be added or removed from the graph. We present TipTap , a suite of algorithms to compute high-quality approximations of the frequent -vertex subgraphs w.r.t. a given threshold, at any time (i.e., point of the stream), with high probability. In contrast to existing state-of-the-art solutions that require iterating over the entire set of subgraphs in the vicinity of the updated edge, TipTap operates by efficiently maintaining a uniform sample of connected -vertex subgraphs, thanks to an optimized neighborhood-exploration procedure. We provide a theoretical analysis of the proposed algorithms in terms of their unbiasedness and of the sample size needed to obtain a desired approximation quality. Our analysis relies on sample-complexity bounds that use Vapnik–Chervonenkis dimension, a key concept from statistical learning theory, which allows us to derive a sufficient sample size that is independent from the size of the graph. The results of our empirical evaluation demonstrates that TipTap returns high-quality results more efficiently and accurately than existing baselines.


Author(s):  
Auroshis Rout ◽  
Brijesh Mainali ◽  
Suneet Singh ◽  
Chetan Singh Solanki
Keyword(s):  

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