Automated Segmentation of Carotid Artery Vessel Wall in MRI

The goal of this study was to determine the effects of microgravity on myofilament protein expression and both passive and active length-force relationships in carotid and femoral arteries. Microgravity was simulated by 20-day hindlimb unweighting (HU) in Wistar male rats, and carotid and femoral artery segments were isolated from both HU and control (CTL) rats for Western blot and length-force analysis. Western blots revealed that HU significantly decreased myosin light chain-20 (MLC-20) protein levels in both carotid and femoral arteries and decreased myosin heavy chain (MHC) in femoral artery. α-Actin levels were not altered by HU treatment in either artery. Length-force analysis demonstrated that HU did not change either passive or active length-force relationships in the femoral artery. HU-treated arterial rings developed significantly less force to 100 mM K+ than CTL, but optimal lengths were identical. In the carotid artery, length-active force curves were identical for both CTL and HU; however the length-passive force curve for HU-treated rings exhibited a steeper slope than CTL, suggesting decreased compliance of the artery wall. In conclusion, our data suggest that the HU-induced decreases in both MLC-20 and MHC in femoral artery are responsible for the decreased contraction to 100 mM K+ in HU-treated femoral artery rings. In the carotid artery, the HU-induced decrease in vessel wall compliance may counter any decrease in contractility caused by the decreased MLC-20 levels.

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High-resolution magnetic resonance vessel wall imaging of chronic intracranial internal carotid artery occlusion

Journal of Neuroradiology ◽

10.1016/j.neurad.2018.04.005 ◽

2018 ◽

Vol 45 (5) ◽

pp. 336-337

Author(s):

Xiangyan Chen ◽

Wenjie Yang ◽

Chiu Wing Chu ◽

Ka Sing Wong ◽

Thomas Wai Hong Leung

Keyword(s):

Magnetic Resonance ◽

High Resolution ◽

Carotid Artery ◽

Internal Carotid Artery ◽

Vessel Wall ◽

Internal Carotid ◽

Artery Occlusion ◽

Carotid Artery Occlusion ◽

Internal Carotid Artery Occlusion ◽

Wall Imaging

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Carotid artery end-to-end anastomosis in the rat using the argon laser

Journal of Neurosurgery ◽

10.3171/jns.1985.63.5.0771 ◽

1985 ◽

Vol 63 (5) ◽

pp. 771-775 ◽

Cited By ~ 34

Author(s):

Stefan Pribil ◽

Stephen K. Powers

Keyword(s):

Carotid Artery ◽

Vessel Wall ◽

Laser System ◽

Argon Laser ◽

Suture Technique ◽

Content Type ◽

Pseudoaneurysm Formation ◽

Vessel Patency ◽

Laser Bonding ◽

End To End

✓ Microvascular end-to-end anastomoses of rat common carotid arteries measuring 0.6 to 0.7 mm in diameter were performed using an argon surgical laser system. Vascular bonding with the argon laser was accomplished in all cases. The anastomosed carotid artery segments were evaluated both angiographically and histologically at 1 day, 1 week, and 1 month after laser bonding. With increasing time after anastomosis, there was a trend toward increasing angiographically proven stenosis of the anastomotic segment and histologically demonstrated pseudoaneurysm formation of the vessel wall at the bonded site. Pseudoaneurysm formation was associated with a dense inflammatory response in the anastomotic vessel segment. In spite of excellent initial tissue bonding and vessel patency, the delayed results of progressive vessel wall disruption and segmental stenosis indicate that further experience in using the argon laser for vessel welding is needed before this method can be accepted as an alternative to current microvascular suture technique.

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3D assessment of the carotid artery vessel wall volume: an imaging biomarker for diagnosis of the atherosclerotic disease

10.1117/12.2216890 ◽

2016 ◽

Author(s):

Mariam Afshin ◽

Tishan Maraj ◽

Tina Binesh Marvasti ◽

Navneet Singh ◽

Alan Moody

Keyword(s):

Carotid Artery ◽

Vessel Wall ◽

Atherosclerotic Disease ◽

Imaging Biomarker

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The Management of Very Small/Blister Internal Carotid Artery Aneurysms

Interventional Neuroradiology ◽

10.1177/159101991101700406 ◽

2011 ◽

Vol 17 (4) ◽

pp. 431-434 ◽

Cited By ~ 7

Author(s):

D.E.J. Le Feuvre ◽

A.G. Taylor

Keyword(s):

Carotid Artery ◽

Natural History ◽

Internal Carotid Artery ◽

Vessel Wall ◽

Internal Carotid ◽

Cerebral Aneurysms ◽

Endovascular Management ◽

Flow Change ◽

Small Blister

Blood blister aneuryms are uncommon lesions that have a poor natural history. Because there is no clear aneurysmal sac to treat they remain challenging lesions to manage whether the approach is endovascular or surgical. Although the management of intracranial cerebral aneurysms has changed subsequent to the results published by the ISAT trial, there still exist groups of aneurysms which do not lend themselves to endovascular management. There are recent reports of successful endovascular management using flow diverting approaches but experience is limited and relying on flow change may be insufficient to prevent re-rupture. Surgery when possible offers the advantage of immediate vessel wall reconstruction.

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Automated registration of multispectral MR vessel wall images of the carotid artery

Medical Physics ◽

10.1118/1.4829503 ◽

2013 ◽

Vol 40 (12) ◽

pp. 121904 ◽

Cited By ~ 12

Author(s):

R. van ˈt Klooster ◽

M. Staring ◽

S. Klein ◽

R. M. Kwee ◽

M. E. Kooi ◽

...

Keyword(s):

Carotid Artery ◽

Vessel Wall ◽

Automated Registration

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Vascular Diameters as Predictive Factors of Recanalization Surgery Outcomes in Internal Carotid Artery Occlusion

Frontiers in Neurology ◽

10.3389/fneur.2021.632063 ◽

2021 ◽

Vol 12 ◽

Author(s):

Chengrui Yan ◽

Jiaru Wang ◽

Ruohan Guo ◽

Weitao Jin ◽

Yang Zhao ◽

...

Keyword(s):

Carotid Artery ◽

Internal Carotid Artery ◽

Predictive Factors ◽

Vessel Wall ◽

Internal Carotid ◽

Artery Occlusion ◽

Carotid Artery Occlusion ◽

Internal Carotid Artery Occlusion ◽

Success Rates ◽

Revascularization Surgery

Background: Revascularization surgery sometimes can achieve recanalization in patients with internal carotid artery occlusion (ICAO). High-resolution vessel wall magnetic resonance imaging (HRVWI) is a feasible technique to give detailed characteristics of the vessel wall, which may help to identify patients that carry higher success rates and more suitable for revascularization surgery.Objective: To examine the association between HRVWI characteristics of ICAO and the success rate of revascularization surgery in ICAO patients.Methods: We conducted a retrospective analysis of 31 ICAO recanalization patients enrolled from October 2017 to May 2019. The clinical data of patients and lesions were collected and analyzed.Results: A total of 31 ICAO patients were enrolled in this study. No significant differences were found between recanalization success and recanalization failure groups with regard to occlusion length, distal end of the occluded segment, and the treatment applied. The ipsilateral-to-contralateral diameter ratios (I/C ratios) of C1 or C2 and the diameter of C7 were positively related to recanalization success. A two-factor predictive model was constructed, and the I/C ratio of C2 < 0.86 and the diameter of C7 < 1.75mm were separately assigned 1 point. The ICAO patients who scored 0, 1, or 2 points had a risk of 5.6% (1/18), 55.6% (5/9), or 100% (4/4) to fail in the recanalization.Conclusions: The I/C ratios of C1 or C2 and the diameter of C7 are predictive factors of a revascularization surgery success in ICAO patients. A risk stratification model involving C2 and C7 was constructed for future clinical applications.

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Quantitative susceptibility mapping improves the detection of calcified carotid vessels by multi-contrast MRI using computed tomography angiography as the reference standard

10.1101/2021.07.07.21260049 ◽

2021 ◽

Author(s):

Thanh D Nguyen ◽

Yan Wen ◽

Jingwen Du ◽

Pascal Spincemaille ◽

Yi Wang ◽

...

Keyword(s):

Computed Tomography ◽

Carotid Artery ◽

Vessel Wall ◽

Carotid Arteries ◽

Susceptibility Mapping ◽

Reference Standard ◽

Quantitative Susceptibility Mapping ◽

Vessel Detection ◽

Carotid Vessel Wall ◽

Carotid Vessels

The objective of this study was to evaluate initial feasibility and improvement in the detection of calcified carotid arteries by including quantitative susceptibility mapping (QSM) in the carotid vessel wall multi-contrast MRI (mcMRI) protocol using CTA as the reference standard. In a pilot cohort of ten patients with significant carotid artery stenosis, calcified vessel detection by mcMRI achieved 64.7% sensitivity and 100% specificity. Adding QSM to mcMRI improved sensitivity to 100% while not affecting specificity.

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