3D assessment of the carotid artery vessel wall volume: an imaging biomarker for diagnosis of the atherosclerotic disease

2016 ◽  
Author(s):  
Mariam Afshin ◽  
Tishan Maraj ◽  
Tina Binesh Marvasti ◽  
Navneet Singh ◽  
Alan Moody
Keyword(s):  
Carotid Artery ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Imaging Biomarker

Simulated microgravity effects on the rat carotid and femoral arteries: role of contractile protein expression and mechanical properties of the vessel wall

2007 ◽  
Vol 102 (4) ◽  
pp. 1595-1603 ◽  
Author(s):  
Sunup Hwang ◽  
Stanislav A. Shelkovnikov ◽  
Ralph E. Purdy
Keyword(s):  
Carotid Artery ◽  
Protein Expression ◽  
Femoral Artery ◽  
Vessel Wall ◽  
Male Rats ◽  
Force Analysis ◽  
Western Blots ◽  
Active Length ◽  
Femoral Arteries ◽  
Protein Levels

The goal of this study was to determine the effects of microgravity on myofilament protein expression and both passive and active length-force relationships in carotid and femoral arteries. Microgravity was simulated by 20-day hindlimb unweighting (HU) in Wistar male rats, and carotid and femoral artery segments were isolated from both HU and control (CTL) rats for Western blot and length-force analysis. Western blots revealed that HU significantly decreased myosin light chain-20 (MLC-20) protein levels in both carotid and femoral arteries and decreased myosin heavy chain (MHC) in femoral artery. α-Actin levels were not altered by HU treatment in either artery. Length-force analysis demonstrated that HU did not change either passive or active length-force relationships in the femoral artery. HU-treated arterial rings developed significantly less force to 100 mM K+ than CTL, but optimal lengths were identical. In the carotid artery, length-active force curves were identical for both CTL and HU; however the length-passive force curve for HU-treated rings exhibited a steeper slope than CTL, suggesting decreased compliance of the artery wall. In conclusion, our data suggest that the HU-induced decreases in both MLC-20 and MHC in femoral artery are responsible for the decreased contraction to 100 mM K+ in HU-treated femoral artery rings. In the carotid artery, the HU-induced decrease in vessel wall compliance may counter any decrease in contractility caused by the decreased MLC-20 levels.

Magnetic resonance vessel wall imaging in intracranial atherosclerotic disease simulating vasculitis

2019 ◽  
Vol 67 (2) ◽  
pp. 588
Author(s):  
PN Sylaja ◽  
K Arun ◽  
Chinmay Nagesh ◽  
C Kesavadas ◽  
SapnaE Sreedharan
Keyword(s):  
Magnetic Resonance ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

Carotid artery end-to-end anastomosis in the rat using the argon laser

1985 ◽  
Vol 63 (5) ◽  
pp. 771-775 ◽  
Author(s):  
Stefan Pribil ◽  
Stephen K. Powers
Keyword(s):  
Carotid Artery ◽  
Vessel Wall ◽  
Laser System ◽  
Argon Laser ◽  
Suture Technique ◽  
Content Type ◽  
Pseudoaneurysm Formation ◽  
Vessel Patency ◽  
Laser Bonding ◽  
End To End

✓ Microvascular end-to-end anastomoses of rat common carotid arteries measuring 0.6 to 0.7 mm in diameter were performed using an argon surgical laser system. Vascular bonding with the argon laser was accomplished in all cases. The anastomosed carotid artery segments were evaluated both angiographically and histologically at 1 day, 1 week, and 1 month after laser bonding. With increasing time after anastomosis, there was a trend toward increasing angiographically proven stenosis of the anastomotic segment and histologically demonstrated pseudoaneurysm formation of the vessel wall at the bonded site. Pseudoaneurysm formation was associated with a dense inflammatory response in the anastomotic vessel segment. In spite of excellent initial tissue bonding and vessel patency, the delayed results of progressive vessel wall disruption and segmental stenosis indicate that further experience in using the argon laser for vessel welding is needed before this method can be accepted as an alternative to current microvascular suture technique.

Pathology of carotid artery atherosclerotic disease

2009 ◽  
pp. 1-21 ◽  
Author(s):  
Renu Virmani ◽  
Allen Burke ◽  
Elena Ladich ◽  
Frank D. Kolodgie
Keyword(s):  
Carotid Artery ◽  
Atherosclerotic Disease

High-Resolution Magnetic Resonance Vessel Wall Imaging in Intracranial Atherosclerotic Disease

2019 ◽  
Vol 1 ◽  
pp. 193-214
Author(s):  
Ramez N. Abdalla ◽  
Donald R. Cantrell ◽  
Alireza Vali ◽  
Michael C. Hurley ◽  
Ali Shaibani ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
High Resolution ◽  
Vessel Wall ◽  
Vessel Wall Imaging ◽  
Atherosclerotic Disease ◽  
Intracranial Atherosclerotic Disease ◽  
Wall Imaging

Real-world experience of extracranial carotid artery interventions for atherosclerotic disease during a 10-year period

2018 ◽  
Vol 37 (6) ◽  
Author(s):  
Konstantinos Spanos ◽  
Christos Karathanos ◽  
Vasileios A. Lachanas ◽  
Aikaterini Drakou ◽  
Konstantinos Stamoulis ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Real World ◽  
Atherosclerotic Disease ◽  
Extracranial Carotid Artery

Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI

2020 ◽  
pp. 197140092098015
Author(s):  
J Scott McNally ◽  
Adam de Havenon ◽  
Seong-Eun Kim ◽  
Chuanzhuo Wang ◽  
Shuping Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
New Zealand ◽  
Magnetic Resonance ◽  
Apolipoprotein E ◽  
Sensitivity And Specificity ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Resonance Imaging ◽  
Intracranial Atherosclerotic Disease ◽  
Human Pathology

Introduction Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human pathology samples are not practical for such analysis, so an animal model is therefore needed. Materials and methods Watanabe heritable hyperlipidemic rabbits and apolipoprotein E knockout rabbits were evaluated against New Zealand white wild-type rabbits. Evaluation of intracranial arteries was performed with vessel wall magnetic resonance imaging and pathological analysis, rating the presence and severity of disease in each segment. Two-tailed t-tests were performed to compare disease occurrence and severity prevalence among rabbit subtypes. Sensitivity and specificity were calculated to assess the diagnostic accuracy of vessel wall magnetic resonance imaging. Results Seventeen rabbits (five Watanabe heritable hyperlipidemic, four apolipoprotein E knockout and eight New Zealand white) were analysed for a total of 51 artery segments. Eleven segments (five Watanabe heritable hyperlipidemic and six apolipoprotein E knockout) demonstrated intracranial atherosclerotic disease on pathology. Disease model animals had lesions more frequently than New Zealand white animals ( P<0.001). The sensitivity and specificity of vessel wall magnetic resonance imaging for the detection of intracranial atherosclerotic disease were 68.8% and 95.2%, respectively. When excluding mild cases to assess vessel wall magnetic resonance imaging accuracy for detecting moderate to severe intracranial atherosclerotic disease lesions, sensitivity improved to 100% with unchanged specificity. Conclusion Intracranial atherosclerotic disease can be reliably produced and detected using 3T vessel wall magnetic resonance imaging-compatible Watanabe heritable hyperlipidemic and ApoE rabbit models. Further analysis is needed to characterize better the development and progression of the disease to correlate tissue-validated animal findings with those in human vessel wall magnetic resonance imaging studies.

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