Joint Myocardial Registration and Segmentation of Cardiac BOLD MRI

Background: Blood oxygen level-dependent magnetic resonance imaging (BOLD-MRI) has been widely used to assess renal oxygenation changes in different kidney diseases in recent years. This study was designed to evaluate and compare renal tissue oxygenation using 2 BOLD-MRI analysis methods, namely, the regional and whole-kidney region of interest (ROI) selection methods. Methods: The study ended up with 10 healthy controls and 40 chronic kidney disease (CKD) patients without dialysis. Their renal BOLD-MRI data were analyzed using whole-kidney ROI selection method and compared with regional ROI selection method. Results: We found the cortical, medullary, and whole-kidney R2* values were significantly higher in CKD patients than those in controls. Compared with the regional ROI selection method, the whole-kidney ROI selection method yielded higher cortical R2* values in both controls and CKD patients. The whole-kidney R2* values of deteriorating renal function group were significantly higher than those in stable renal function group. Conclusions: Cortical and medullary oxygenation was decreased significantly in CKD patients compared with the healthy controls, particularly in the medulla. The whole-kidney R2* values were positively correlated with kidney function and inversely correlated with the estimated glomerular filtration rate and effective renal plasma flow. Whole-Kidney R2* value might effectively predict the progression of renal function in patients with CKD.

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Longitudinal Reproducibility of CO2-Triggered BOLD MRI for the Hemodynamic Evaluation of Adult Patients with Moyamoya Angiopathy

Cerebrovascular Diseases ◽

10.1159/000513301 ◽

2021 ◽

pp. 1-7

Author(s):

Constantin Roder ◽

Uwe Klose ◽

Helene Hurth ◽

Cornelia Brendle ◽

Marcos Tatagiba ◽

...

Keyword(s):

Intraclass Correlation ◽

Collateral Flow ◽

Surgical Revascularization ◽

Bold Mri ◽

Promising Tool ◽

Hemodynamic Evaluation ◽

Group 2 ◽

Group 1

Background and Purpose: Hemodynamic evaluation of moyamoya patients is crucial to decide the treatment strategy. Recently, CO2-triggered BOLD MRI has been shown to be a promising tool for the hemodynamic evaluation of moyamoya patients. However, the longitudinal reliability of this technique in follow-up examinations is unknown. This study aims to analyze longitudinal follow-up data of CO2-triggered BOLD MRI to prove the reliability of this technique for long-term control examinations in moyamoya patients. Methods: Longitudinal CO2 BOLD MRI follow-up examinations of moyamoya patients with and without surgical revascularization have been analyzed for all 6 vascular territories retrospectively. If revascularization was performed, any directly (by the disease or the bypass) or indirectly (due to change of collateral flow after revascularization) affected territory was excluded based on angiography findings (group 1). In patients without surgical revascularization between the MRI examinations, all territories were analyzed (group 2). Results: Eighteen moyamoya patients with 39 CO2 BOLD MRI examinations fulfilled the inclusion criteria. The median follow-up between the 2 examinations was 12 months (range 4–29 months). For 106 vascular territories analyzed in group 1, the intraclass correlation coefficient was 0.784, p < 0.001, and for group 2 (84 territories), it was 0.899, p < 0.001. Within the total follow-up duration of 140 patient months, none of the patients experienced a new stroke. Conclusions: CO2 BOLD MRI is a promising tool for mid- and long-term follow-up examinations of cerebral hemodynamics in moyamoya patients. Systematic prospective evaluation is required prior to making it a routine examination.

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BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.24555 ◽

2013 ◽

Vol 41 (1) ◽

pp. 110-116 ◽

Cited By ~ 8

Author(s):

Bjoern P. Schoennagel ◽

Jin Yamamura ◽

Roland Fischer ◽

Manuela Tavares de Sousa ◽

Marcela Weyhmiller ◽

...

Keyword(s):

Fetal Sheep ◽

Bold Mri ◽

The Brain

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The effect of renal denervation on kidney oxygenation as determined by BOLD MRI in patients with hypertension

European Radiology ◽

10.1007/s00330-014-3583-1 ◽

2015 ◽

Vol 25 (7) ◽

pp. 1984-1992 ◽

Cited By ~ 8

Author(s):

E. E. Vink ◽

A. Boer ◽

W. L. Verloop ◽

W. Spiering ◽

M. Voskuil ◽

...

Keyword(s):

Renal Denervation ◽

Bold Mri

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Oxygenation in cervical cancer and normal uterine cervix assessed using BOLD MRI: Initial experiences

Gynecologic Oncology ◽

10.1016/j.ygyno.2010.12.267 ◽

2011 ◽

Vol 120 ◽

pp. S112

Author(s):

J. Lea ◽

R. Hallac ◽

Y. Ding ◽

Q. Yuan ◽

R. McColl ◽

...

Keyword(s):

Cervical Cancer ◽

Uterine Cervix ◽

Bold Mri

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BOLD-MRI in ten patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by the stenotic artery

Magnetic Resonance Materials in Physics Biology and Medicine ◽

10.1007/bf02590635 ◽

1999 ◽

Vol 8 (1) ◽

pp. 48-54 ◽

Cited By ~ 25

Author(s):

Christian M. Wacker ◽

Michael Bock ◽

Andreas W. Hartlep ◽

Wolfgang R. Bauer ◽

Gerhard van Kaick ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Capillary Recruitment ◽

Bold Mri ◽

Artery Disease

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Reduced oxygenation but not fibrosis defined by functional magnetic resonance imaging predicts the long-term progression of chronic kidney disease

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfy324 ◽

2018 ◽

Vol 35 (6) ◽

pp. 964-970 ◽

Cited By ~ 11

Author(s):

Kei Sugiyama ◽

Tsutomu Inoue ◽

Eito Kozawa ◽

Masahiro Ishikawa ◽

Akira Shimada ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Chronic Kidney Disease ◽

Regression Analysis ◽

Linear Regression Analysis ◽

Resonance Imaging ◽

Bold Mri ◽

Adc Values ◽

The Mean ◽

Rate Of Decline ◽

Observation Period

Abstract Background Although chronic hypoxia and fibrosis may be a key to the progression of chronic kidney disease (CKD), a noninvasive means of measuring these variables is not yet available. Here, using blood oxygen level–dependent (BOLD) and diffusion-weighted (DW) magnetic resonance imaging (MRI), we assessed changes in renal tissue oxygenation and fibrosis, respectively, and evaluated their correlation with prognosis for renal function. Methods The study was conducted under a single-center, longitudinal, retrospective observational design. We examined the prognostic significance of T2* values of BOLD-MRI and apparent diffusion coefficient (ADC) values on DW-MRI and other clinical parameters. The rate of decline in estimated glomerular filtration rate (eGFR) was calculated by linear regression analysis using changes in eGFR during the observation period. Results A total of 91 patients were enrolled, with a mean age of 55.8 ± 15.6 years. Among patients, 51 (56.0%) were males and 38 (41.8%) had diabetes mellitus. The mean eGFR was 49.2 ± 28.9 mL/min/1.73 m2 and the mean observation period was 5.13 years. ADC values of DW-MRI but not T2* values of BOLD-MRI were well correlated with eGFR at the initial time point. The mean annual rate of decline in eGFR during the 5-year observation period was −1.92 ± 3.00 mL/min/1.73 m2. On multiple linear regression analysis, the rate of decline in eGFR was significantly correlated with eGFR at the start point, period average amount of proteinuria and T2* values, but not with ADC values (t = 2.980, P = 0.004). Conclusions Reduced oxygenation as determined by low T2* values on BOLD-MRI is a clinically useful marker of CKD progression.

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