Role Analysis: The Foundation for Selection Systems

Author(s):  
Máire Kerrin ◽  
Liz Mossop ◽  
Emma Morley ◽  
Gail Fleming ◽  
Charlotte Flaxman
2006 ◽  
Author(s):  
Jamie L. Bomer ◽  
Nicole R. Bourdeau ◽  
Nita R. French ◽  
Michael Klein ◽  
Ryan A. Ross ◽  
...  

2008 ◽  
Author(s):  
Seymour Adler ◽  
Therese Macan ◽  
Lee Konczak ◽  
Paul Muchinsky ◽  
Amy Grubb ◽  
...  

1980 ◽  
Vol 19 (04) ◽  
pp. 187-194
Author(s):  
J.-Ph. Berney ◽  
R. Baud ◽  
J.-R. Scherrer

It is well known that Frame Selection Systems (FFS) have proved both popular and effective in physician-machine and patient-machine dialogue. A formal algorithm for definition of a Frame Selection System for handling man-machine dialogue is presented here. Besides, it is shown how the natural medical language can be handled using the approach of a tree branching logic. This logic appears to be based upon ordered series of selections which enclose a syntactic structure. The external specifications are discussed with regard to convenience and efficiency. Knowing that all communication between the user and the application programmes is handled only by FSS software, FSS contributes to achieving modularity and, therefore, also maintainability in a transaction-oriented system with a large data base and concurrent accesses.


2018 ◽  
Vol 24 (19) ◽  
pp. 2055-2075 ◽  
Author(s):  
Kalliopi Kostelidou ◽  
Ilias Matis ◽  
Georgios Skretas

Neurodegenerative Diseases (ND) are a major threat to the aging population and the lack of a single preventive or disease-modifying agent only serves to increase their impact. In the past few years, protein misfolding and the subsequent formation of neurotoxic oligomeric/aggregated protein species have emerged as a unifying theme underlying the pathology of these complex diseases. Recently developed microbial genetic screens and selection systems for monitoring ND-associated protein misfolding have allowed the establishment of highthroughput assays for the identification of cellular factors and processes that are important mediators of NDassociated proteotoxicities. In addition, such systems have facilitated the discovery of synthetic and natural compounds with the ability to rescue the misfolding and the associated pathogenic effects of aggregation-prone proteins associated with NDs. This review outlines such available systems in bacteria and yeast, whose usage will likely accelerate the pre-clinical discovery process for effective drugs against a variety of NDs with high socioeconomic impact.


2013 ◽  
Vol 23 (1) ◽  
pp. 50-70 ◽  
Author(s):  
Dianna L. Stone ◽  
Kimberly M. Lukaszewski ◽  
Eugene F. Stone-Romero ◽  
Teresa L. Johnson

Sign in / Sign up

Export Citation Format

Share Document