Towards the Use of a Tree Branching Logic in the Environment of a Hospital Information System

1980 ◽  
Vol 19 (04) ◽  
pp. 187-194
Author(s):  
J.-Ph. Berney ◽  
R. Baud ◽  
J.-R. Scherrer
Keyword(s):  
Syntactic Structure ◽  
Large Data ◽  
Selection System ◽  
Frame Selection ◽  
Knowing That ◽  
Medical Language ◽  
Selection Systems ◽  
Definition Of ◽  
Man Machine Dialogue ◽  
Oriented System

It is well known that Frame Selection Systems (FFS) have proved both popular and effective in physician-machine and patient-machine dialogue. A formal algorithm for definition of a Frame Selection System for handling man-machine dialogue is presented here. Besides, it is shown how the natural medical language can be handled using the approach of a tree branching logic. This logic appears to be based upon ordered series of selections which enclose a syntactic structure. The external specifications are discussed with regard to convenience and efficiency. Knowing that all communication between the user and the application programmes is handled only by FSS software, FSS contributes to achieving modularity and, therefore, also maintainability in a transaction-oriented system with a large data base and concurrent accesses.

Towards the Use of a Tree Branching Logic in the Environment of a Hospital Information System

1980 ◽  
Vol 19 (04) ◽  
pp. 187-194 ◽  
Author(s):  
J.-Ph. Berney ◽  
R. Baud ◽  
J.-R. Scherrer
Keyword(s):  
Syntactic Structure ◽  
Large Data ◽  
Selection System ◽  
Frame Selection ◽  
Knowing That ◽  
Medical Language ◽  
Selection Systems ◽  
Definition Of ◽  
Man Machine Dialogue ◽  
Oriented System

It is well known that Frame Selection Systems (FFS) have proved both popular and effective in physician-machine and patient-machine dialogue. A formal algorithm for definition of a Frame Selection System for handling man-machine dialogue is presented here. Besides, it is shown how the natural medical language can be handled using the approach of a tree branching logic. This logic appears to be based upon ordered series of selections which enclose a syntactic structure. The external specifications are discussed with regard to convenience and efficiency. Knowing that all communication between the user and the application programmes is handled only by FSS software, FSS contributes to achieving modularity and, therefore, also maintainability in a transaction-oriented system with a large data base and concurrent accesses.

scholarly journals Development of the myzozoan aquatic parasite Perkinsus marinus as a versatile experimental genetic model organism

2021 ◽  
Author(s):  
Elin Einarsson ◽  
Imen Lassadi ◽  
Jana Zielinski ◽  
Qingtian Guan ◽  
Tobias Wyler ◽  
...  
Keyword(s):  
Transgene Expression ◽  
Genetic Model ◽  
Genetically Modify ◽  
Model Organism ◽  
Evolutionary Model ◽  
Selection System ◽  
Perkinsus Marinus ◽  
Variable Expression ◽  
Selection Systems ◽  
Efficient Selection

The phylum Perkinsozoa is an aquatic parasite lineage that has devastating effects on commercial and natural mollusc populations, and also comprises parasites of algae, fish and amphibians. They are related to, and share much of their biology with, dinoflagellates and apicomplexans and thus offer excellent genetic models for both parasitological and evolutionary studies. Genetic transformation has been previously achieved for select Perkinsus spp. but with few tools for transgene expression and only limited selection efficacy. We thus sought to expand the power of experimental genetic tools for Perkinsus marinus — the principal perkinsozoan model to date. We constructed a modular plasmid assembly system that enables expression of multiple genes simultaneously. We developed an efficient selection system for three drugs, puromycin, bleomycin and blasticidin, that achieves transformed cell populations in as little as three weeks. We developed and quantified eleven new promoters of variable expression strength. Furthermore, we identified that genomic integration of transgenes is predominantly via non-homologous recombination and often involves transgene fragmentation including deletion of some introduced elements. To counter these dynamic processes, we show that bi-cistronic transcripts using the viral 2A peptides can couple selection systems to the maintenance of the expression of a transgene of interest. Collectively, these new tools and insights provide new capacity to efficiently genetically modify and study Perkinsus as an aquatic parasite and evolutionary model.

scholarly journals A spectral theory for Wright’s inbreeding coefficients and related quantities

PLoS Genetics ◽  
2021 ◽  
Vol 17 (7) ◽  
pp. e1009665
Author(s):  
Olivier François ◽  
Clément Gain
Keyword(s):  
Population Structure ◽  
Genetic Variation ◽  
Population Genetic ◽  
Principal Component ◽  
Large Data ◽  
Population Subdivision ◽  
Adaptive Genetic Variation ◽  
Genomic Locus ◽  
Inbreeding Coefficients ◽  
Definition Of

Wright’s inbreeding coefficient, FST, is a fundamental measure in population genetics. Assuming a predefined population subdivision, this statistic is classically used to evaluate population structure at a given genomic locus. With large numbers of loci, unsupervised approaches such as principal component analysis (PCA) have, however, become prominent in recent analyses of population structure. In this study, we describe the relationships between Wright’s inbreeding coefficients and PCA for a model of K discrete populations. Our theory provides an equivalent definition of FST based on the decomposition of the genotype matrix into between and within-population matrices. The average value of Wright’s FST over all loci included in the genotype matrix can be obtained from the PCA of the between-population matrix. Assuming that a separation condition is fulfilled and for reasonably large data sets, this value of FST approximates the proportion of genetic variation explained by the first (K − 1) principal components accurately. The new definition of FST is useful for computing inbreeding coefficients from surrogate genotypes, for example, obtained after correction of experimental artifacts or after removing adaptive genetic variation associated with environmental variables. The relationships between inbreeding coefficients and the spectrum of the genotype matrix not only allow interpretations of PCA results in terms of population genetic concepts but extend those concepts to population genetic analyses accounting for temporal, geographical and environmental contexts.

scholarly journals Mesothelioma: one disease, many definitions. Comparative linguistic analysis in a “health literacy” perspective

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Antonio Maconi ◽  
Mariateresa Dacquino ◽  
Federica Viazzi ◽  
Emanuela Bovo ◽  
Federica Grosso ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Health Literacy ◽  
English Language ◽  
Syntactic Structure ◽  
Basic Knowledge ◽  
Patient Portal ◽  
Medical Field ◽  
Definition Of ◽  
The Uk ◽  
Medical Concepts

Objectives: The aim of this paper is to demonstrate how, while remaining within a specific field such as medicine, it is possible to use different languages depending on the target audience (doctors, professionals from other fields or patients) in order to improve its degree of health literacy. In particular, the aim is to show how even the definition of a disease, which should in principle be unambiguous, can in fact be linguistically adapted to the reader's basic knowledge. Methodology: Five definitions of mesothelioma are examined, analysed lexically, syntactically and graphically. Specifically, this comparison is made on three main levels, which in turn have different nuances: popular, including definitions from Wikipedia and the UK Mesothelioma patient portal; intermediate, corresponding to the Collins English language dictionary; and specialist, with definitions from the MeSH thesaurus and the Orphanet database. Results: At the end of the comparative analysis, it is possible to state that in linguistic and Health Literacy terms there is no single definition for this rare disease but as many definitions as there are targets. In particular, they vary in syntactic structure, graphic form and vocabulary, as they have to use technicalities typical of the medical field but have different nuances of complexity. Conclusion: A comparison of the definitions shows that the degree of readability does not always correspond to that of comprehensibility. The analysis demonstrates that it is difficult to explain complex medical concepts to practitioners and patients in a simple, clear and usable way and that this requires specific techniques of Health Literacy, related to both the linguistic and graphic aspects. The comparison of definitions is therefore a methodological premise for the creation of brochures dedicated to mesothelioma and the revision of the "Mai soli" site for mesothelioma patients.

scholarly journals Robustness, Sensitivity, and Sampling Variability of Pareto-Optimal Selection System Solutions to Address the Quality-Diversity Trade-Off

2019 ◽  
Vol 23 (3) ◽  
pp. 535-568
Author(s):  
Wilfried De Corte ◽  
Paul R. Sackett ◽  
Filip Lievens
Keyword(s):  
Simulation Study ◽  
Critical Issue ◽  
Pareto Optimal ◽  
Optimal Selection ◽  
Selection System ◽  
Trade Off ◽  
Sampling Variability ◽  
Optimal Balance ◽  
Selection Systems ◽  
System Designs

In case that both the goals of selection quality and diversity are important, a selection system is Pareto-optimal (PO) when its implementation is expected to result in an optimal balance between the levels achieved with respect to both these goals. The study addresses the critical issue whether PO systems, as computed from calibration conditions, continue to perform well when applied to a large variety of different validation selection situations. To address the key issue, we introduce two new measures for gauging the achievement of these designs and conduct a large simulation study in which we manipulate 10 factors (related to the selection situation, sensitivity/robustness, and the selection system) that cumulate in a design with 3,888 cells and 24 selection systems. Results demonstrate that PO systems are superior to other, non-PO systems (including unit weighed system designs) both in terms of the achievement measures as well as in terms of yielding more often a better quality/diversity trade-off. The study also identifies a number of conditions that favor the achievement of PO systems in realistic selection situations.

scholarly journals Understanding value creation in cultural industries: strategies for creating and managing meaning

2020 ◽  
Vol 2 (3) ◽  
pp. 165-180
Author(s):  
Eden Yin ◽  
Nelson Phillips
Keyword(s):  
Value Creation ◽  
Critical Role ◽  
Selection System ◽  
Cultural Products ◽  
Content Type ◽  
Product Categories ◽  
Collective Creativity ◽  
Selection Systems ◽  
One Step ◽  
Entire Society

Purpose This paper aims to analyse the valuation of cultural products and explores what this process means for organizations involved in their production and marketing. Design/methodology/approach The authors develop the arguments using a number of mini-cases and industry examples. Findings The main thesis is that the meaningfulness and value ambiguity of cultural products shift the focus of valuation away from the products themselves towards how certain agents in the socio-cultural environment identify and certify these products. This paper discuss how valuation takes place via selection systems and how the nature of cultural products drives the dominance of one selection system over others. Research limitations/implications Theories on value creation needs to take consideration of the critical role played by the selection system instead of just the firms that produce these products. Practical implications Organizations engaged in producing highly symbolic products need to manage selection systems and related industry dynamics to establish an enduring competitive advantage. Social implications Value creation is a collective social efforts. Every member of the society can play a central role in this process. Better engaging various member of the society to enable them actively participate in the value creation process is what organizations today need to consider, instead of just treating individuals in the society as a “customer” who only passively consume. This research calls for the true empowerment of every member of the society to facilitate collective creativity and participation in the value creation endeavour that benefits the entire society as a whole. Originality/value It is the first paper that has created a conceptual link between the type of selection system and product categories. In other words, it takes existing literature on value creation and selection system one step further by creating the alignment or match between types of selection system and types of product categories. Therefore, it offers academics and practitioners a much detailed understanding on how value creation is conducted across different product categories.

Constructing Corpora for the Development and Evaluation of Paraphrase Systems

2008 ◽  
Vol 34 (4) ◽  
pp. 597-614 ◽  
Author(s):  
Trevor Cohn ◽  
Chris Callison-Burch ◽  
Mirella Lapata
Keyword(s):  
Natural Language Processing ◽  
Natural Language ◽  
Language Processing ◽  
Syntactic Structure ◽  
Nominal Data ◽  
Parallel Corpus ◽  
Word Alignments ◽  
Definition Of

Automatic paraphrasing is an important component in many natural language processing tasks. In this article we present a new parallel corpus with paraphrase annotations. We adopt a definition of paraphrase based on word alignments and show that it yields high inter-annotator agreement. As Kappa is suited to nominal data, we employ an alternative agreement statistic which is appropriate for structured alignment tasks. We discuss how the corpus can be usefully employed in evaluating paraphrase systems automatically (e.g., by measuring precision, recall, and F1) and also in developing linguistically rich paraphrase models based on syntactic structure.

Moving Window Two-Dimensional Correlation Spectroscopy and Determination of Signal-To-Noise Threshold in Correlation Spectra

2003 ◽  
Vol 57 (8) ◽  
pp. 996-1006 ◽  
Author(s):  
Slobodan Šašić ◽  
Yukihiro Ozaki
Keyword(s):  
Large Data ◽  
Correlation Spectroscopy ◽  
Data Matrix ◽  
Data Sets ◽  
Complex Data ◽  
Moving Window ◽  
Two Dimensional ◽  
Complex Data Sets ◽  
Coexisting Species ◽  
Definition Of

In this paper we report two new developments in two-dimensional (2D) correlation spectroscopy; one is the combination of the moving window concept with 2D spectroscopy to facilitate the analysis of complex data sets, and the other is the definition of the noise level in synchronous/asynchronous maps. A graphical criterion for the latter is also proposed. The combination of the moving window concept with correlation spectra allows one to split a large data matrix into smaller and simpler subsets and to analyze them instead of computing overall correlation. A three-component system that mimics a consecutive chemical reaction is used as a model for the illustration of the two ideas. Both types of correlation matrices, variable–variable and sample–sample, are analyzed, and a very good agreement between the two is met. The proposed innovations enable one to comprehend the complexity of the data to be analyzed by 2D spectroscopy and thus to avoid the risks of over-interpretation, liable to occur whenever improper caution about the number of coexisting species in the system is taken.

scholarly journals PERSPECTIVES FOR DEVELOPMENT OF BLOCKCHAIN APPLICATIONS IN UKRAINE

2018 ◽  
pp. 35-48 ◽  
Author(s):  
Svitlana O. Spasiteleva ◽  
Volodymyr L. Buriachok
Keyword(s):  
Large Data ◽  
Security Level ◽  
Successful Implementation ◽  
Development Platform ◽  
Blockchain Technology ◽  
Current State ◽  
New Models ◽  
Private And Public ◽  
Security Infrastructure ◽  
Definition Of

The article is devoted to the definition of problems using of blockchain technologies, and ways to overcome them to create distributed, secure applications. The paper considers the theoretical fundamentals of blockchain technologies and blockchain applications, new models of blockchain business, blockchain applications development platform, blockchain applications security, blockchain applications development problems, prospects for further research. The analysis of recent research and publications in the field of blockchain technologies are made in the article. Based on this analysis, it was determined that the blockchain industry has not yet completed the process of generating a generally accepted multilevel technology description. The overview of existing models of business blockchain, their characteristics and areas of application are done in the article. Software tools for creating and maintaining blockchain applications are considered. The article deals with the features, advantages and problems of using blockchain technology for creating distributed, secure applications. The problem of integration of new and existing private systems with an open blockchains is considered. A possible solution to this problem is the creation of a blockchain authentication service to implement a global security level. Such a service can become a standard security infrastructure for new models of mixed private and public systems that will be useful to all participants in different areas of the economy. The directions of development of protected blockchain applications in the sphere of public administration and private business in Ukraine are determined. In addition, the priority tasks that need to be solved for successful implementation of technology in Ukraine are determined based on the analysis of the current state of development of blockchains. There are three main areas of development of blockade technology: standardization, application security and integration of block systems with existing private systems and modern technologies of artificial intelligence, large data and the Internet of things, and described prospects for further research for them.

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