ПЕРФУЗІЙНА ДИСФУНКЦІЯ ПРИ ГОСТРОМУ ПАНКРЕАТИТІ: ПЕРСПЕКТИВНІ НАПРЯМКИ УДОСКОНАЛЕННЯ ДІАГНОСТИКИ ТА СТРАТИФІКАЦІЇ ЗАХВОРЮВАННЯ

Introduction. Acute pancreatitis (AP) is one of the most common diseases of the digestive system that require hospitalization. To date, the problem of stratification and differential diagnosis of AP in the early stages remains unresolved, which encourages the search for new methods of diagnosis and prediction of the severity of AP. Aim. To evaluate the possibility of creating a clinically oriented system of stratification and prognosis of AP on the basis of dynamic changes in microcirculation depending on the duration of the disease and severity of AP. Materials and methods. Assessment of the state of microcirculation (MC) of patients by laser Doppler flowmetry (LDF) was performed with the “LAKK-02” device. Kruskal-Wallis non-parametric analysis of variance and the median test were used to test statistical hypotheses when comparing independent samples. Pairwise comparison of independent samples was performed using the Mann-Whitney U test. Results. The study determined the indicators of MC in patients with different AP severity degrees on the first day of the disease. The microcirculation parameter (MP) in patients with mild, moderate, and severe AP was 3.9; 3.8 and 6.8 perfusion units (p.u.), respectively. The blood flow modulation rate (ơ) was 0.52; 0.54 and 0.69 p.u. in mild, moderate, and severe AP. In our study, the coefficient of variation (Kv) averaged 17.3%; 20.0% and 11.7% in patients with mild, moderate, and severe AP, respectively. Conclusions. LDF in AP is an informative method of diagnosing the state of MC, which is a universal link in all pathophysiological reactions of the organism. Changes of MC in AP depend on the severity of AP and the period of the disease. The pathophysiological microcirculatory phenomena, revealed on the first day of the disease, provide us with the perspectives of early clinical distinguishing the moderate and severe forms of AP from the so-called group of “destructive forms”.

Development an optimization plan for redistributing pension assets applying information technologies

The issue of the significance of the role of information technologies in the pension system was highlighted. The information and communication model of the state regulation of financial support of the pension system in the market of non-banking financial services was considered. The essence of information and communication support of the risk-oriented approach to the system of accumulative pension provision, which involves preventing the information and technological probability of risks, was explored. The issues of development of non-bank financial institutions as entities of aggregate financial potential were explored and promising directions of increasing the efficiency of their functioning with the use of information technologies were outlined. The necessity of introducing the mechanism of information and communication provision of the state regulation of accumulative system of pension provision by means of mandatory payment of contributions to individual pension accounts and their further investment as an important component of social protection of the population was considered. The algorithm of construction of the mechanism of information and communication provision of the risk-oriented approach to the accumulative pension system was proposed. The main indicators of the implementation of the accumulative component of the pension system were analyzed. The need for the interaction of the elements of the risk-oriented system of accumulative pensions was substantiated. Information technologies of investment of pension savings as a long-term investment resource in interaction of elements of the risk-oriented system of the accumulative pension provision were considered. The needs of introducing a risk-oriented approach to accumulated assets to strengthen social protection of participants in the non-banking financial services market were highlighted. The results of the redistribution between the cluster proved a close relationship of incomes of population and long-term pension savings.

The influence of the risk-oriented system of funded pension provision on the socio-economic security of the state

Introduction. The implementation of a risk-oriented approach is an important issue for implementation in various fields. The purpose of the paper is to assess the impact of the risk-oriented system of funded pension provision on the socio-economic security of the state. The method of analysis of T. Saati's hierarchies was used to assess the impact of the instruments of the risk-oriented system of accumulative pension provision on the socio-economic security of the state. Results. The highest priority is given to 3 instruments: use of tools for identification and formation of risk profile of accumulative pension entities – 1st place (0,295), introduction of internal risk management system for funded pension entities in the field of funded pension provision – 2nd place (0,278); establishment of general requirements to the performance indicators of the subjects of accumulative pension provision, in particular financial monitoring – 3rd place (0,166). Conclusion. Scenarios for the development of socio-economic security of the state are modeled. It is determined that the scenario of accelerated development is more probable in assessing the impact of instruments for implementing a risk-oriented system of funded pension provision, in particular: use of tools for identification and formation of a risk profile of the activities of the subjects of the accumulative pension provision; use the criteria of risk-oriented composition of investment areas of pension assets in the field of funded pension provision; use of FINTECH, REGTECH in the field of funded pension provision; use of financial mediation in the field of funded pension provision; establishment of general requirements to the performance indicators of the subjects of funded pension provision, in particular financial monitoring; introduction of an internal risk management system for the activities of the subjects of the funded pension provision in the sphere of the funded pension provision.

Design and Development of Web based E-Commerce Application for Logo Sales “Tokologo” Using Codeigniter

A logo can be considered as the main success factor of a company. It is not only the representation of a company vision but also can used to attract public attention. Hence, we develop an e-commerce application to simplify production process of the logo, i.e. by two bridging gaps between companies with logo designers and by properly maintaining reasonable pricing or production cost. We use the waterfall and the UML tools, implemented in the Codeigniter framework, for developing the application. Because both of them are still considered as the most reliable tools in the object-oriented system development. There are also several tests conducted in this work to ensure that the application can work properly according to our design purposes.

MODELING OF THE SYSTEM OF FAMILY PREPARATION FOR PSYCHOLOGICAL AND PEDAGOGICAL CORRECTIONAL SUPPORT OF AN EARLY-AGE CHILD WITH DISABILITIES

The article reveals the need to prepare a family raising a child with disabilities for psychological and pedagogical correctional work. A model of a personality-oriented system of preparing parents for psychological and pedagogical correctional support for young children with disabilities is provided. The model is built taking into account the individual characteristics of parents, such as social status, psychological state, type of motivation to acquire knowledge in the field of upcoming activities. The model of the system of preparing parents to support a child with disabilities is based on the structural and content components included in it, which ensure a high level of target orientation of the system for the development of parents ' stable readiness and ability for new activities. The article assumes that the proposed system of training parents will ensure an increase in the quality of psychological and pedagogical correctional support for young children with disabilities.