Effects of Mechanical Stimulation on the Mechanical Properties and Calcification Process of Immature Chick Bone Tissue in Culture

2009 ◽  
pp. 2197-2200
Author(s):  
T. Matsumoto ◽  
K. Ichikawa ◽  
M. Nakagaki ◽  
K. Nagayama
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Mechanical Stimulation ◽  
Calcification Process

scholarly journals Effects of cyclic compression on the mechanical properties and calcification process of immature chick bone tissue in culture

Bone Reports ◽  
2017 ◽  
Vol 6 ◽  
pp. 120-128 ◽  
Author(s):  
Eijiro Maeda ◽  
Masashi Nakagaki ◽  
Katsuhisa Ichikawa ◽  
Kazuaki Nagayama ◽  
Takeo Matsumoto
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Cyclic Compression ◽  
Calcification Process

scholarly journals Development of Biopolymeric Hybrid Scaffold-Based on AAc/GO/nHAp/TiO2 Nanocomposite for Bone Tissue Engineering: In-Vitro Analysis

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1319
Author(s):  
Muhammad Umar Aslam Khan ◽  
Wafa Shamsan Al-Arjan ◽  
Mona Saad Binkadem ◽  
Hassan Mehboob ◽  
Adnan Haider ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Guar Gum ◽  
Porous Scaffolds ◽  
Vitro Assay ◽  
Vitro Analysis ◽  
Nanocomposite Scaffolds

Bone tissue engineering is an advanced field for treatment of fractured bones to restore/regulate biological functions. Biopolymeric/bioceramic-based hybrid nanocomposite scaffolds are potential biomaterials for bone tissue because of biodegradable and biocompatible characteristics. We report synthesis of nanocomposite based on acrylic acid (AAc)/guar gum (GG), nano-hydroxyapatite (HAp NPs), titanium nanoparticles (TiO2 NPs), and optimum graphene oxide (GO) amount via free radical polymerization method. Porous scaffolds were fabricated through freeze-drying technique and coated with silver sulphadiazine. Different techniques were used to investigate functional group, crystal structural properties, morphology/elemental properties, porosity, and mechanical properties of fabricated scaffolds. Results show that increasing amount of TiO2 in combination with optimized GO has improved physicochemical and microstructural properties, mechanical properties (compressive strength (2.96 to 13.31 MPa) and Young’s modulus (39.56 to 300.81 MPa)), and porous properties (pore size (256.11 to 107.42 μm) and porosity (79.97 to 44.32%)). After 150 min, silver sulfadiazine release was found to be ~94.1%. In vitro assay of scaffolds also exhibited promising results against mouse pre-osteoblast (MC3T3-E1) cell lines. Hence, these fabricated scaffolds would be potential biomaterials for bone tissue engineering in biomedical engineering.

Role of Interfacial Interactions on Mechanical Properties of Biomimetic Composites for Bone Tissue Engineering

2005 ◽  
Vol 898 ◽  
Author(s):  
Devendra Verma ◽  
Rahul Bhowmik ◽  
Bedabibhas Mohanty ◽  
Dinesh R Katti ◽  
Kalpana S Katti
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Response ◽  
Density Ratio ◽  
Interfacial Interactions ◽  
Porous Composites ◽  
Properties Of Composites

AbstractInterfaces play an important role in controlling the mechanical properties of composites. Optimum mechanical strength of scaffolds is of prime importance for bone tissue engineering. In the present work, molecular dynamics simulations and experimental studies have been conducted to study effect of interfacial interactions on mechanical properties of composites for bone replacement. In order to mimic biological processes, hydroxyapatite (HAP) is mineralized in presence of polyacrylic acid (PAAc) (in situ HAP). Further, solid and porous composites of in situ HAP with polycaprolactone (PCL) are made. Mechanical tests of composites of in situ HAP with PAAc have shown improved strain recovery, higher modulus/density ratio and also improved mechanical response in simulated body fluid (SBF). Simulation studies indicate potential for calcium bridging between –COO− of PAAc and surface calcium of HAP. This fact is also supported by infrared spectroscopic studies. PAAc modified surfaces of in situ HAP offer means to control the microstructure and mechanical response of porous composites. Nanoindentation experiments indicate that apatite grown on in situ HAP/PCL composites from SBF has improved elastic modulus and hardness. This work gives insight into the interfacial mechanisms responsible for mechanical response as well as bioactivity in biomaterials.

Effect of Bone Tumor and Osteoporosis on Mechanical Properties of Bone and Bone Tissue Properties: A Finite Element Study

2007 ◽  
Author(s):  
Vipul P. Gohil ◽  
Paul K. Canavan ◽  
Hamid Nayeb-Hashemi
Keyword(s):  
Mechanical Properties ◽  
Finite Element ◽  
Bone Density ◽  
Bone Tissue ◽  
Bone Tumor ◽  
Cellular Structure ◽  
Bone Tumors ◽  
World Health ◽  
Tissue Stiffness ◽  
Tissue Properties

This research is aimed to study the variations in the biomechanical behavior of bone and bone tissues with osteoporosis and bone tumors. Osteoporosis and bone tumors reduce the mechanical strength of bone, which creates a greater risk of fracture. In the United States alone, ten million individuals, eight million of whom are women, are estimated to already have osteoporosis, and almost 34 million more are estimated to have low bone mass (osteopenia) placing them at increased risk for osteoporosis. World Health Organization defines osteopenia, as a bone density between one and two and a half standard deviations (SD) below the bone density of a normal young adult. (Osteoporosis is defined as 2.5 SD or more below that reference point.). Together, osteoporosis and osteopenia are expected to affect an estimated 52 million women and men age 50 and older by 2010, and 61 million by 2020. The current medical cost of osteoporosis total is nearly about $18 billion in the U.S. each year. There is a dearth of literature that addresses the effects of osteoporosis on bone tissue properties. Furthermore, there are few studies published related to the effect of bone tumors such as Adamantinoma of long bones, Aneurysmal bone cyst, Hemangioma and others on overall behavior of bone. To understand the variations in bio-mechanical properties of internal tissues of bone with osteoporosis and bone tumor, a 2D finite element (FE) model of bone is developed using ANSYS 9.0 ® (ANSYS Inc., Canonsburg, PA). Trabecular bone is modeled using hexagonal and voronoi cellular structure. This finite element model is subjected to change in BVF (bone volume fraction) and bone architecture caused by osteoporosis. The bone tumor is modeled as finer multi-cellular structure and the effects of its size, location, and property variation of tumor on overall bone behavior are studied. Results from this analysis and comparative data are used to determine behavior of bone and its tissue over different stage of osteoporosis and bone tumor. Results indicate that both bone tumor and osteoporosis significantly change the mechanical properties of the bone. The results show that osteoporosis increases the bone tissue stiffness significantly as BVF reduces. Bone tissue stiffness is found to increase by 80 percent with nearly 55 percent reduction of BVF. The results and methods developed in this research can be implemented to monitor variation in bio-mechanical properties of bone up to tissue level during medication or to determine type and time for need of external support such as bracing.

Hybrid nanostructured hydroxyapatite–chitosan composite scaffold: bioinspired fabrication, mechanical properties and biological properties

2015 ◽  
Vol 3 (23) ◽  
pp. 4679-4689 ◽  
Author(s):  
Ya-Ping Guo ◽  
Jun-Jie Guan ◽  
Jun Yang ◽  
Yang Wang ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Biological Properties ◽  
Chitosan Composite

A bioinspired strategy has been developed to fabricate a hybrid nanostructured hydroxyapatite–chitosan composite scaffold for bone tissue engineering.

scholarly journals Mechanical properties of Gelatin –Hydroxyapatite composite for bone tissue engineering

2015 ◽  
Vol 50 (1) ◽  
pp. 15-20 ◽  
Author(s):  
MJ Hossan ◽  
MA Gafur ◽  
MM Karim ◽  
AA Rana
Keyword(s):  
Mechanical Properties ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Testing Machine ◽  
Casting Process ◽  
Raw Material ◽  
Potential Candidate ◽  
Oven Drying ◽  
Hydroxyapatite Composite ◽  
Properties Of Composites

In this study, hydroxyapatite (HAp) and gelatin (GEL) scaffolds were prepared to mimic the mineral and organic component of natural bone. The raw material was first compounded and resulting composite were molded into the petridishes. Using Solvent casting process, it is possible to produce scaffolds with mechanical and structural properties close to natural trabecular bone.The mechanical properties of composites were investigated by Thermo-mechanical analyzer (TMA), Vickers microhardness tester, Universal testing machine. It was observed that the composite has maximum tensile strength of 37.13MPa ( oven drying) and % elongation of 7.68 (Oven drying) and 2.04 (Natural drying) at 15% of Hap respectively. These results demonstrate that the prepared composite scaffold is a potential candidate for bone tissue engineering.Bangladesh J. Sci. Ind. Res. 50(1), 15-20, 2015

scholarly journals In Vitro and In Vivo Characterization of N-Acetyl-L-Cysteine Loaded Beta-Tricalcium Phosphate Scaffolds

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Yong-Seok Jang ◽  
Phonelavanh Manivong ◽  
Yu-Kyoung Kim ◽  
Kyung-Seon Kim ◽  
Sook-Jeong Lee ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Water Soluble ◽  
Tetrazolium Salt ◽  
Porous Scaffolds ◽  
Tissue Engineering Application ◽  
Beta Tricalcium Phosphate

Beta-tricalcium phosphate bioceramics are widely used as bone replacement scaffolds in bone tissue engineering. The purpose of this study is to develop beta-tricalcium phosphate scaffold with the optimum mechanical properties and porosity and to identify the effect of N-acetyl-L-cysteine loaded to beta-tricalcium phosphate scaffold on the enhancement of biocompatibility. The various interconnected porous scaffolds were fabricated using slurries containing various concentrations of beta-tricalcium phosphate and different coating times by replica method using polyurethane foam as a passing material. It was confirmed that the scaffold of 40 w/v% beta-tricalcium phosphate with three coating times had optimum microstructure and mechanical properties for bone tissue engineering application. The various concentration of N-acetyl-L-cysteine was loaded on 40 w/v% beta-tricalcium phosphate scaffold. Scaffold group loaded 5 mM N-acetyl-L-cysteine showed the best viability of MC3T3-E1 preosteoblastic cells in the water-soluble tetrazolium salt assay test.

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