Hybrid nanostructured hydroxyapatite–chitosan composite scaffold: bioinspired fabrication, mechanical properties and biological properties

2015 ◽  
Vol 3 (23) ◽  
pp. 4679-4689 ◽  
Author(s):  
Ya-Ping Guo ◽  
Jun-Jie Guan ◽  
Jun Yang ◽  
Yang Wang ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Biological Properties ◽  
Chitosan Composite

A bioinspired strategy has been developed to fabricate a hybrid nanostructured hydroxyapatite–chitosan composite scaffold for bone tissue engineering.

scholarly journals A dual-application poly (dl-lactic-co-glycolic) acid (PLGA)-chitosan composite scaffold for potential use in bone tissue engineering

2017 ◽  
Vol 28 (16) ◽  
pp. 1966-1983 ◽  
Author(s):  
Yamina Boukari ◽  
Omar Qutachi ◽  
David J. Scurr ◽  
Andrew P. Morris ◽  
Stephen W. Doughty ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Glycolic Acid ◽  
Composite Scaffold ◽  
Chitosan Composite ◽  
Potential Use

scholarly journals TiO2 doped chitosan/hydroxyapatite/halloysite nanotube membranes with enhanced mechanical properties and osteoblast-like cell response for application in bone tissue engineering

RSC Advances ◽  
2019 ◽  
Vol 9 (68) ◽  
pp. 39768-39779
Author(s):  
Sarim Khan ◽  
Viney Kumar ◽  
Partha Roy ◽  
Patit Paban Kundu
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cell Response ◽  
Halloysite Nanotubes ◽  
Biological Properties ◽  
Halloysite Nanotube ◽  
Nanotube Membranes ◽  
Hydroxyapatite Composite

This two-stage study aims to optimize the amount of halloysite nanotubes and TiO2 in a chitosan/nano-hydroxyapatite composite to tailor the mechanical and biological properties for application in bone tissue engineering.

Evaluation of the in vitro biodegradation and biological behavior of poly(lactic-co-glycolic acid)/nano-fluorhydroxyapatite composite microsphere-sintered scaffold for bone tissue engineering

2017 ◽  
Vol 33 (2) ◽  
pp. 146-159 ◽  
Author(s):  
Mohammadreza Tahriri ◽  
Fathollah Moztarzadeh ◽  
Arash Tahriri ◽  
Hossein Eslami ◽  
Kimia Khoshroo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Weight Loss ◽  
Simulated Body Fluid ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Body Fluid ◽  
Bone Repair ◽  
Glycolic Acid ◽  
Composite Scaffold

The objective of this research was to study the degradation and biological characteristics of the three-dimensional porous composite scaffold made of poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite microsphere using sintering method for potential bone tissue engineering. Our previous experimental results demonstrated that poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite composite scaffold with a ratio of 4:1 sintered at 90ºC for 2 h has the greatest mechanical properties and a proper pore structure for bone repair applications. The weight loss percentage of both poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite and poly(lactic- co-glycolic acid) scaffolds demonstrated a monotonic trend with increasing degradation time, that is, the incorporation of nano-fluorhydroxyapatite into polymeric scaffold could lead to weight loss in comparison with that of pure poly(lactic- co-glycolic acid). The pH change for composite scaffolds showed that there was a slight decrease until 2 weeks after immersion in simulated body fluid, followed by a significant increase in the pH of simulated body fluid without a scaffold at the end of immersion time. The mechanical properties of composite scaffold were higher than that of poly(lactic- co-glycolic acid) scaffold at total time of incubation in simulated body fluid; however, it should be noted that the incorporation of nano-fluorhydroxyapatite into composite scaffold leads to decline in the relatively significant mechanical strength and modulus during hydrolytic degradation. In addition, MTT assay and alkaline phosphatase activity results defined that a general trend of increasing cell viability was seen for poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite scaffold sintered by time when compared to control group. Eventually, experimental results exhibited poly(lactic- co-glycolic acid)/nano-fluorhydroxyapatite microsphere-sintered scaffold is a promising scaffold for bone repair.

Fabrication and characterization of electrospinning/3D printing bone tissue engineering scaffold

RSC Advances ◽  
2016 ◽  
Vol 6 (112) ◽  
pp. 110557-110565 ◽  
Author(s):  
Yinxian Yu ◽  
Sha Hua ◽  
Mengkai Yang ◽  
Zeze Fu ◽  
Songsong Teng ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Tissue Engineering Scaffold ◽  
Fabrication And Characterization

A composite scaffold was fabricated with a method involving both electrospinning and 3D printing to give microscale pores and good mechanical properties. Biocompatibility and cell infiltration on the scaffold was evaluated by an in vitro study.

Preparation of PLLA/HAP/β-TCP Composite Scaffold for Bone Tissue Engineering

2014 ◽  
Vol 513-517 ◽  
pp. 143-146 ◽  
Author(s):  
Xue Jun Wang ◽  
Tao Lou ◽  
Jing Yang ◽  
Zhen Yang ◽  
Kun Peng He
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Lactic Acid ◽  
Phase Separation ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Thermally Induced Phase Separation ◽  
Composite Scaffolds ◽  
Thermally Induced

In this study, a nanofibrous poly (L-lactic acid) (PLLA) scaffold reinforced by Hydroxyapatite (HAP) and β-tricalcium phosphate (β-TCP) was fabricated using the thermally induced phase separation method. The composite scaffold morphology showed a nanofibrous PLLA matrix and evenly distributed β-TCP/HAP particles. The composite scaffold had interconnective micropores and the pore size ranged 2-10 μm. Introducing β-TCP/HAP particles into PLLA matrix significantly improved the mechanical properties of the composite scaffold. In summary, the new composite scaffolds show a great deal promise for use in bone tissue engineering.

Porous Hydroxyapatite/Chitosan/Carboxymethyl Cellulose Scaffolds with Tunable Microstructures for Bone Tissue Engineering

2019 ◽  
Vol 819 ◽  
pp. 9-14 ◽  
Author(s):  
Kanharit Wongsawichai ◽  
Arada Kingkaew ◽  
Aninart Pariyaisut ◽  
Supang Khondee
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Carboxymethyl Cellulose ◽  
Cell Attachment ◽  
Biological Properties ◽  
Porous Hydroxyapatite ◽  
Porous Microstructure

Bone tissue engineering is an alternative approach to generate bone using biomaterials and cells. Hydroxyapatite (HA) has good biocompatibility, osteoinductivity, and osteoconductivity. However, it has limited utility due to poor mechanical properties and slow degradation rate. To improve mechanical properties and to modify degradation profile, hydroxyapatite was tethered in chitosan (CS) and carboxymethyl cellulose (CMC) complex. Gelatin was incorporated to promote cell attachment and polyvinyl alcohol (PVA) was used to improve mechanical strength of this scaffold. The physico-mechanical and biological properties of these scaffolds were investigated. Fourier transform infrared (FTIR) analysis and X-ray diffraction (XRD) showed the incorporation of hydroxyapatite in polymer matrix. The scaffolds had density, compressive strength, and Young’s modulus in the range of 0.24-0.30 g/cm3, 0.028-0.035 MPa, 0.178-0.560 MPa, respectively. The scaffolds had porosity of 69-91 percent. Higher content of PVA decreased porosity of scaffolds. Scanning electron microscope showed porous microstructure with pore size in the range of 60-183 μm. In vitro test on MC3T3-E1 preosteoblast cells showed negligible cytotoxicity of scaffolds. The data suggested that HA/CS/CMC/gelatin/PVA scaffold has potential applications in bone tissue engineering.

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