A Hybrid Agent Based and Differential Equation Model of Body Size Effects on Pathogen Replication and Immune System Response

2009 ◽  
pp. 14-18 ◽  
Author(s):  
Soumya Banerjee ◽  
Melanie E. Moses
Keyword(s):  
Differential Equation ◽  
Immune System ◽  
Body Size ◽  
Size Effects ◽  
Equation Model ◽  
System Response ◽  
Differential Equation Model ◽  
Agent Based ◽  
Hybrid Agent ◽  
Immune System Response

scholarly journals Scaling in the Immune System: PhD Thesis

2019 ◽  
Author(s):  
soumya banerjee
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Body Size ◽  
Human Health ◽  
Response Rates ◽  
System Response ◽  
Metabolic Rates ◽  
Viral Dynamics ◽  
Immune System Response ◽  
Phd Thesis

How different is the immune system in a human from that of a mouse? Do pathogens replicate at the same rate in different species? Answers to these questions have impact on human health since multi-host pathogens that jump from animals to humans affect millions worldwide.It is not known how rates of immune response and viral dynamics vary from species to species and how they depend on species body size. Metabolic scalingtheory predicts that intracellular processes will be slower in larger animals since cellular metabolic rates are slower. We test how rates of pathogenesis and immune system response rates depend on species body size.

An enhanced agent based model of the immune system response

2006 ◽  
Vol 244 (2) ◽  
pp. 77-79 ◽  
Author(s):  
V. Baldazzi ◽  
F. Castiglione ◽  
M. Bernaschi
Keyword(s):  
Immune System ◽  
System Response ◽  
Agent Based Model ◽  
Agent Based ◽  
Immune System Response

scholarly journals NCMP-05. DECODING THE IMMUNE SYSTEM RESPONSE TO LEPTOMENINGEAL METASTASIS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii124-ii124
Author(s):  
Jan Remsik ◽  
Xinran Tong ◽  
Ugur Sener ◽  
Danille Isakov ◽  
Yudan Chi ◽  
...  
Keyword(s):  
Immune System ◽  
Immune Cells ◽  
Leptomeningeal Metastasis ◽  
System Response ◽  
Idle State ◽  
The Central Nervous System ◽  
Health And Disease ◽  
Immune System Response ◽  
Therapeutic Protocols ◽  
Brain And Spinal Cord

Abstract For decades, the central nervous system was considered to be an immune privileged organ with limited access to systemic immunity. However, the leptomeninges, the cerebrospinal fluid (CSF)-filled anatomical structure that protects the brain and spinal cord, represent a relatively immune-rich environment. Despite the presence of immune cells, complications in the CSF, such as infectious meningitis and a neurological development of cancer known as leptomeningeal metastasis, are difficult to treat and are frequently fatal. We show that immune cells entering the CSF are held in an ‘idle’ state that limits their cytotoxic arsenal and antigen presentation machinery. To understand this underappreciated neuroanatomic niche, we used unique mouse models and rare patient samples to characterize its cellular composition and critical signaling events in health and disease at a single-cell resolution. Revealing the mediators of CSF immune response will allow us to re-evaluate current therapeutic protocols and employ rational combinations with immunotherapies, therefore turning the patient’s own immune system into an active weapon against pathogens and cancer.

scholarly journals A spatially varying stochastic differential equation model for animal movement

2018 ◽  
Vol 12 (2) ◽  
pp. 1312-1331 ◽  
Author(s):  
James C. Russell ◽  
Ephraim M. Hanks ◽  
Murali Haran ◽  
David Hughes
Keyword(s):  
Differential Equation ◽  
Stochastic Differential Equation ◽  
Animal Movement ◽  
Equation Model ◽  
Differential Equation Model ◽  
Spatially Varying
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