Neural Networks Based Adaptive Control of a Fermentation Bioprocess for Lactic Acid Production

Author(s):  
Emil Petre ◽  
Dan Selişteanu ◽  
Dorin Şendrescu
2015 ◽  
Vol 48 (8) ◽  
pp. 1087-1092 ◽  
Author(s):  
Karen Vanessa Gonzalez ◽  
Sihem Tebbani ◽  
Didier Dumur ◽  
Filipa Lopes ◽  
Dominique Pareau ◽  
...  

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
Emil Petre ◽  
Dan Selişteanu

This paper presents the design and the analysis of an indirect adaptive control strategy for a lactic acid production, which is carried out in continuous stirred tank bioreactors. Firstly, an indirect adaptive control structure based on the nonlinear process model is derived by combining a linearizing control law with a new parameter estimator. This estimator is used for on-line estimation of the bioprocess unknown kinetics, avoiding the introduction of a state observer. Secondly, a tuning procedure of estimator design parameters is achieved by stability analysis of the control scheme. The effectiveness and performance of estimation and control algorithms are illustrated by numerical simulations applied in the case of a lactic fermentation bioprocess for which kinetic dynamics are strongly nonlinear, time varying, and completely unknown, and not all the state variables are measurable.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Beatriz Martines de Souza ◽  
Mayara Souza Silva ◽  
Aline Silva Braga ◽  
Patrícia Sanches Kerges Bueno ◽  
Paulo Sergio da Silva Santos ◽  
...  

AbstractThis in vitro study evaluated the protective effect of titanium tetrafluoride (TiF4) varnish and silver diamine fluoride (SDF) solution on the radiation-induced dentin caries. Bovine root dentin samples were irradiated (70 Gy) and treated as follows: (6 h): 4% TiF4 varnish; 5.42% NaF varnish; 30% SDF solution; placebo varnish; or untreated (negative control). Microcosm biofilm was produced from human dental biofilm (from patients with head-neck cancer) mixed with McBain saliva for the first 8 h. After 16 h and from day 2 to day 5, McBain saliva (0.2% sucrose) was replaced daily (37 °C, 5% CO2) (biological triplicate). Demineralization was quantified by transverse microradiography (TMR), while biofilm was analyzed by using viability, colony-forming units (CFU) counting and lactic acid production assays. The data were statistically analyzed by ANOVA (p < 0.05). TiF4 and SDF were able to reduce mineral loss compared to placebo and the negative control. TiF4 and SDF significantly reduced the biofilm viability compared to negative control. TiF4 significantly reduced the CFU count of total microorganism, while only SDF affected total streptococci and mutans streptococci counts. The varnishes induced a reduction in lactic acid production compared to the negative control. TiF4 and SDF may be good alternatives to control the development of radiation-induced dentin caries.


Heliyon ◽  
2021 ◽  
Vol 7 (5) ◽  
pp. e07079
Author(s):  
Joel Romial Ngouénam ◽  
Chancel Hector Momo Kenfack ◽  
Edith Marius Foko Kouam ◽  
Pierre Marie Kaktcham ◽  
Rukesh Maharjan ◽  
...  

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