Receptor Cross-Talk

2017 ◽  
pp. 1-6
Author(s):  
Steven A. Rosenzweig ◽  
David M. Neskey
Keyword(s):  
Cross Talk ◽  
Receptor Cross Talk

Inactive AT1 angiotensin receptor acts as a signaling hub: a novel mechanism of receptor cross-talk

2018 ◽  
Author(s):  
Andras D Toth ◽  
Susanne Prokop ◽  
Pal Gyombolai ◽  
Peter Varnai ◽  
Vsevolod V Gurevich ◽  
...  
Keyword(s):  
Cross Talk ◽  
Angiotensin Receptor ◽  
Receptor Cross Talk

PGE2 triggers recovery of transmucosal resistance via EP receptor cross talk in porcine ischemia-injured ileum

2001 ◽  
Vol 281 (2) ◽  
pp. G375-G381 ◽  
Author(s):  
Anthony T. Blikslager ◽  
Susan M. Pell ◽  
Karen M. Young
Keyword(s):  
Cross Talk ◽  
Splice Variants ◽  
Camp Content ◽  
Ep Receptors ◽  
Ussing Chambers ◽  
A 23187 ◽  
Receptor Interactions ◽  
Intracellular Ca ◽  
Ep Receptor ◽  
Receptor Cross Talk

16,16-Dimethyl-PGE2 (PGE2) may interact with one of four prostaglandin type E (EP) receptors, which signal via cAMP (via EP2 or EP4 receptors) or intracellular Ca2+ (via EP1 receptors). Furthermore, EP3 receptors have several splice variants, which may signal via cAMP or intracellular Ca2+. We sought to determine the PGE2 receptor interactions that mediate recovery of transmucosal resistance ( R) in ischemia-injured porcine ileum. Porcine ileum was subjected to 45 min of ischemia, after which the mucosa was mounted in Ussing chambers. Tissues were pretreated with indomethacin (5 μM). Treatment with the EP1, EP2, EP3, and EP4 agonist PGE2 (1 μM) elevated R twofold and significantly increased tissue cAMP content, whereas the EP2 and EP4 agonist deoxy-PGE1 (1 μM) or the EP1 and EP3 agonist sulprostone (1 μM) had no effect. However, a combination of deoxy-PGE1 and sulprostone stimulated synergistic elevations in R and tissue cAMP content. Furthermore, treatment of tissues with deoxy-PGE1 and the Ca2+ ionophore A-23187 stimulated synergistic increases in R and cAMP, indicating that PGE2 triggers recovery of R via EP receptor cross talk mechanisms involving cAMP and intracellular Ca2+.

Retinoid Receptor Cross-Talk

2016 ◽  
pp. 4059-4062
Author(s):  
Athanasios G. Papavassiliou ◽  
Michalis V. Karamouzis
Keyword(s):  
Cross Talk ◽  
Retinoid Receptor ◽  
Receptor Cross Talk

scholarly journals A Fish Leukocyte Immune-Type Receptor Uses a Novel Intracytoplasmic Tail Networking Mechanism to Cross-Inhibit the Phagocytic Response

2020 ◽  
Vol 21 (14) ◽  
pp. 5146
Author(s):  
Chenjie Fei ◽  
Myron A. Zwozdesky ◽  
James L. Stafford
Keyword(s):  
Cross Talk ◽  
Ictalurus Punctatus ◽  
Immune Cell ◽  
Integrated Control ◽  
Immunoglobulin Superfamily ◽  
Functional Assessments ◽  
Inhibitory Signaling ◽  
Receptor Cross Talk ◽  
Cross Inhibition ◽  
Phagocytic Response

Channel catfish (Ictalurus punctatus) leukocyte immune-type receptors (IpLITRs) are a family of immunoregulatory proteins shown to regulate several innate immune cell effector responses, including phagocytosis. The precise mechanisms of IpLITR-mediated regulation of the phagocytic process are not entirely understood, but we have previously shown that different IpLITR-types use classical as well as novel pathways for controlling immune cell-mediated target engulfment. To date, all functional assessments of IpLITR-mediated regulatory actions have focused on the independent characterization of select IpLITR-types in transfected cells. As members of the immunoglobulin superfamily, many IpLITRs share similar extracellular Ig-like domains, thus it is possible that various IpLITR actions are influenced by cross-talk mechanisms between different IpLITR-types; analogous to the paired innate receptor paradigm in mammals. Here, we describe in detail the co-expression of different IpLITR-types in the human embryonic AD293 cell line and examination of their receptor cross-talk mechanisms during the regulation of the phagocytic response using imaging flow cytometry, confocal microscopy, and immunoprecipitation protocols. Overall, our data provides interesting new insights into the integrated control of phagocytosis via the antagonistic networking of independent IpLITR-types that requires the selective recruitment of inhibitory signaling molecules for the initiation and sustained cross-inhibition of phagocytosis.

Prolonged 5-HT1A/5-HT2A receptor cross-talk is absent prior to adulthood in rats

Neuroreport ◽  
2008 ◽  
Vol 19 (15) ◽  
pp. 1457-1461 ◽  
Author(s):  
Maureen L. Petrunich ◽  
Francisca Garcia ◽  
Gonzalo A. Carrasco ◽  
George Battaglia
Keyword(s):  
Cross Talk ◽  
Receptor Cross Talk

scholarly journals Cross-Talk between P2X and NMDA Receptors

2020 ◽  
Vol 21 (19) ◽  
pp. 7187
Author(s):  
Larry Rodriguez ◽  
Catherine Yi ◽  
Cameron Chu ◽  
Quentin Duriez ◽  
Sharyse Watanabe ◽  
...  
Keyword(s):  
Cross Talk ◽  
Gaba Receptors ◽  
Xenopus Laevis Oocytes ◽  
Aspartate Receptor ◽  
C Terminus ◽  
Electrode Voltage ◽  
Receptor Cross Talk ◽  
New Evidence ◽  
Purinergic P2x Receptors

Purinergic P2X receptors (P2X) are ATP-gated ion channels widely expressed in the CNS. While the direct contribution of P2X to synaptic transmission is uncertain, P2X reportedly affect N-methyl-D-aspartate receptor (NMDAR) activity, which has given rise to competing theories on the role of P2X in the modulation of synapses. However, P2X have also been shown to participate in receptor cross-talk: an interaction where one receptor (e.g., P2X2) directly influences the activity of another (e.g., nicotinic, 5-HT3 or GABA receptors). In this study, we tested for interactions between P2X2 or P2X4 and NMDARs. Using two-electrode voltage-clamp electrophysiology experiments in Xenopus laevis oocytes, we demonstrate that both P2X2 and P2X4 interact with NMDARs in an inhibited manner. When investigating the molecular domains responsible for this phenomenon, we found that the P2X2 c-terminus (CT) could interfere with both P2X2 and P2X4 interactions with NMDARs. We also report that 11 distal CT residues on the P2X4 facilitate the P2X4–NMDAR interaction, and that a peptide consisting of these P2X4 CT residues (11C) can disrupt the interaction between NMDARs and P2X2 or P2X4. Collectively, these results provide new evidence for the modulatory nature of P2X2 and P2X4, suggesting they might play a more nuanced role in the CNS.

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