Platelet-Rich Plasma in Muscle Injuries: When and How It Can Be Used

2015 ◽  
pp. 1-7
Author(s):  
Matjaz Vogrin ◽  
Robi Kelc
Keyword(s):  
Platelet Rich Plasma ◽  
Muscle Injuries

Tissue Engineered Successful Reconstruction of a Complex Traumatized Lower Extremity

2021 ◽  
Vol 11 (9) ◽  
Author(s):  
Srinjoy Saha
Keyword(s):  
Minimally Invasive ◽  
Soft Tissues ◽  
Platelet Rich Plasma ◽  
Thigh Muscle ◽  
Muscle Injuries ◽  
Invasive Approach ◽  
Novel Approach ◽  
Duration Of Surgery ◽  
Biomaterial Application ◽  
Split Skin

Introduction: Tissue engineered reconstruction is a minimally invasive approach for healing major complex wounds successfully. It combines accurate, conservative debridement with a specially adapted suction method, platelet-rich plasma (PRP) injections, and biomaterial application to salvage injured tissues and grows new soft tissues over wounds. Case Report: A healthy young man in his early 30s presented to our emergency department with complex knee-thigh injuries following a high-velocity automobile accident. Degloved anterolateral thigh, severe thigh muscle injuries, and ruptured extensor patellar mechanism were observed. Accurate conservative (as opposed to radical) debridement and PRP injections salvaged the injured muscles and tendons. Specially carved reticulated foam wrapped around the injured ischemic muscles, followed by low negative, short intermittent, cyclical suction therapy. Wound exploration 4 days apart revealed progressive improvements with considerable vascularization of the injured soft tissues within 2 weeks. Thereafter, meticulous reconstruction of the salvaged muscles and tendons restored anatomical congruity. An absorbable synthetic biomaterial covered the sizeable open wound with vast areas of exposed tendons. Five weeks later, exuberant granulating tissue ingrowth within the biomaterial filled up the tissue defect. A split-skin graft covered the remaining raw areas, which “took” completely. Early rehabilitation enabled the patient to return to active work, play contact sports, and perform strenuous activities effortlessly. Conclusion: Minimally invasive tissue engineered reconstruction is a novel approach using a series of simple minimally invasive procedures. It lessens the duration of surgery and anesthesia, maximizes soft-tissue salvage, lowers morbidity, minimizes hospitalization, saves costs, and improves the patient’s quality of life significantly. Keywords: Mangled extremity, Limb salvage, Financial, Trauma, Modified negative pres

scholarly journals Platelet-rich plasma in muscle injuries: A possible kind of treatment in regenerative sport traumatology

2018 ◽  
Vol 18 (4) ◽  
Author(s):  
Caforio Marco ◽  
Mantelli Patrizia ◽  
Bisogno Luigi
Keyword(s):  
Platelet Rich Plasma ◽  
Muscle Injuries

Hip Pain in Athletes: Part 1—How to Work Up, Diagnose, and Manage Core Muscle Injuries (Athletic Pubalgia)

2018 ◽  
Vol 02 (03) ◽  
pp. 135-140
Author(s):  
Johannes Roedl ◽  
Adam Zoga ◽  
William Meyers ◽  
Alexander Poor
Keyword(s):  
Femoroacetabular Impingement ◽  
Skeletal Muscles ◽  
Platelet Rich Plasma ◽  
Special Consideration ◽  
Entire Body ◽  
Muscle Injuries ◽  
Athletic Pubalgia ◽  
The Core ◽  
Common Causes ◽  
Work Up

AbstractLower abdominal and groin injuries are among the most common causes of pain in athletes. Those that involve the skeletal muscles of the core, defined as the entire body from the chest to the midthigh, are called core muscle injuries. In this review, the authors will describe the anatomy and pathophysiology of core muscle injuries in detail, as well as the appropriate work-up and management. Special consideration is given to the important interrelationship between core muscle injuries and intrinsic hip pathology, such as femoroacetabular impingement, and to the drawbacks of treating these injuries with platelet-rich plasma.

scholarly journals Tissue Engineered Strategies for Skeletal Muscle Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Umile Giuseppe Longo ◽  
Mattia Loppini ◽  
Alessandra Berton ◽  
Filippo Spiezia ◽  
Nicola Maffulli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Muscle Injury ◽  
Platelet Rich Plasma ◽  
Residual Effects ◽  
Current Therapy ◽  
Muscle Injuries ◽  
Cell Based Therapy ◽  
Proliferation And Differentiation ◽  
Inflammatory Drugs

Skeletal muscle injuries are common in athletes, occurring with direct and indirect mechanisms and marked residual effects, such as severe long-term pain and physical disability. Current therapy consists of conservative management including RICE protocol (rest, ice, compression, and elevation), nonsteroidal anti-inflammatory drugs, and intramuscular corticosteroids. However, current management of muscle injuries often does not provide optimal restoration to preinjury status. New biological therapies, such as injection of platelet-rich plasma and stem-cell-based therapy, are appealing. Although some studies support PRP application in muscle-injury management, reasons for concern persist, and further research is required for a standardized and safe use of PRP in clinical practice. The role of stem cells needs to be confirmed, as studies are still limited and inconsistent. Further research is needed to identify mechanisms involved in muscle regeneration and in survival, proliferation, and differentiation of stem cells.

Sports and exercise injuries

2013 ◽  
pp. 1390-1394
Author(s):  
Nicola Maffulli ◽  
Angelo Del Buono
Keyword(s):  
Sports Medicine ◽  
Platelet Rich Plasma ◽  
Current Trend ◽  
Muscle Injuries ◽  
Ligament Injuries ◽  
Early Return ◽  
Sport Activities ◽  
Level I ◽  
Sports And Exercise ◽  
Regenerative Therapies

Muscle, tendon, and ligament injuries are common practice in sports medicine. Muscle injuries do not require surgery but heal with traditional conservative measures, whereas surgery may be indicated in chronic high-demand patients who need to early return to preinjury activity. Ligament injuries are responsive to conservative management but, when resulting clinical instability impairs daily and sport activities, surgical repair or reconstruction are recommended. Tendinopathy is an overuse syndrome, the diagnosis of which is clinical, and confirmed by the presence of degenerative changes at histology, without any signs of inflammatory disease. The current trend is to adopt a conservative approach which also includes platelet-rich plasma and sclerosing injections, and to advocate surgery in unresponsive patients. Even though regenerative therapies are emerging, available knowledge is still scanty and literature lacks level I studies to support their use.

scholarly journals Treatment of Muscle Injuries with Platelet-Rich Plasma: a Review of the Literature

2018 ◽  
Vol 11 (4) ◽  
pp. 635-642 ◽  
Author(s):  
Kian Setayesh ◽  
Arturo Villarreal ◽  
Andrew Gottschalk ◽  
John M. Tokish ◽  
W. Stephen Choate
Keyword(s):  
Platelet Rich Plasma ◽  
Review Of The Literature ◽  
Muscle Injuries

Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury

2020 ◽  
Vol 48 (9) ◽  
pp. 2277-2286
Author(s):  
Shama R. Iyer ◽  
Amanda L. Scheiber ◽  
Paul Yarowsky ◽  
R. Frank Henn ◽  
Satoru Otsuru ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Muscle Injury ◽  
Contractile Function ◽  
Recovery Of Function ◽  
Platelet Rich Plasma ◽  
Skeletal Muscle Regeneration ◽  
Muscle Injuries ◽  
Novel Therapy

Background: Clinical use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) has gained momentum as treatment for muscle injuries. Exosomes, or small cell–derived vesicles, could be helpful if they could deliver the same or better physiological effect without cell transplantation into the muscle. Hypothesis: Local delivery of exosomes derived from PRP (PRP-exos) or MSCs (MSC-exos) to injured muscles hastens recovery of contractile function. Study Design: Controlled laboratory study. Methods: In a rat model, platelets were isolated from blood, and MSCs were isolated from bone marrow and expanded in culture; exosomes from both were isolated through ultracentrifugation. The tibialis anterior muscles were injured in vivo using maximal lengthening contractions. Muscles were injected with PRP-exos or MSC-exos (immediately after injury and 5 and 10 days after injury); controls received an equal volume of saline. Histological and biochemical analysis was performed on tissues for all groups. Results: Injury resulted in a significant loss of maximal isometric torque (66% ± 3%) that gradually recovered over 2 weeks. Both PRP-exos and MSC-exos accelerated recovery, with similar faster recovery of contractile function over the saline-treated group at 5, 10, and 15 days after injury ( P < .001). A significant increase in centrally nucleated fibers was seen with both types of exosome groups by day 15 ( P < .01). Genes involved in skeletal muscle regeneration were modulated by different exosomes. Muscles treated with PRP-exos had increased expression of Myogenin gene ( P < .05), whereas muscles treated with MSC-exos had reduced expression of TGF-β ( P < .05) at 10 days after muscle injury. Conclusion: Exosomes derived from PRP or MSCs can facilitate recovery after a muscle strain injury in a small-animal model likely because of factors that can modulate inflammation, fibrosis, and myogenesis. Clinical Relevance: Given their small size, low immunogenicity, and ease with which they can be obtained, exosomes could represent a novel therapy for many orthopaedic ailments.

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