Role of Growth Factor Signaling Pathways in Biliary Tract Cancer

2014 ◽  
pp. 33-44 ◽  
Author(s):  
Kaoru Kiguchi ◽  
John DiGiovanni
Keyword(s):  
Growth Factor ◽  
Signaling Pathways ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Growth Factor Signaling ◽  
Tract Cancer

scholarly journals Disrupted transforming growth factor-? signaling and deregulated growth in human biliary tract cancer cells

2000 ◽  
Vol 86 (6) ◽  
pp. 782-789 ◽  
Author(s):  
Shujiro Yazumi ◽  
Kohaku Ko ◽  
Norihiko Watanabe ◽  
Hisashi Shinohara ◽  
Kiyotsugu Yoshikawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Cells ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Transforming Growth Factor ◽  
Growth Factor Signaling ◽  
Tract Cancer

Role of adjuvant and neoadjuvant therapy for resectable biliary tract cancer.

2021 ◽  
Author(s):  
Satoshi Nara ◽  
Minoru Esaki ◽  
Daisuke Ban ◽  
Takeshi Takamoto ◽  
Takahiro Mizui ◽  
...  
Keyword(s):  
Neoadjuvant Therapy ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Tract Cancer ◽  
Adjuvant And Neoadjuvant Therapy

scholarly journals Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3327
Author(s):  
Zhixiang Wang
Keyword(s):  
Cell Cycle ◽  
Growth Factor ◽  
Signaling Pathways ◽  
Tyrosine Kinases ◽  
Cell Cycle Progression ◽  
Phase Cell ◽  
Growth Factor Signaling ◽  
Cycle Progression ◽  
M Phase

The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase. Cell cycle progression is mediated by cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving force of cell cycle progression is growth factor-initiated signaling pathways that control the activity of various Cdk–cyclin complexes. While the mechanism underlying the role of growth factor signaling in G1 phase of cell cycle progression has been largely revealed due to early extensive research, little is known regarding the function and mechanism of growth factor signaling in regulating other phases of the cell cycle, including S, G2, and M phase. In this review, we briefly discuss the process of cell cycle progression through various phases, and we focus on the role of signaling pathways activated by growth factors and their receptor (mostly receptor tyrosine kinases) in regulating cell cycle progression through various phases.

Prognostic value of dickkopf-1 and ß-catenin expression according to the antitumor immunity of CD8-positive tumor-infiltrating lymphocytes in biliary tract cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16172-e16172
Author(s):  
Seoree Kim ◽  
Yoon Ho Ko ◽  
Hye Sung Won ◽  
Ji Hyun Yang ◽  
Der Sheng Sun ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Cox Regression ◽  
Research Network ◽  
Antigen Retrieval ◽  
Tract Cancer ◽  
Tissue Sections ◽  
Dkk1 Expression

e16172 Background: Despite recent advancements in the understanding of the molecular biology of biliary tract cancer (BTC), target therapy and immunotherapy have demonstrated only limited efficacy, with cytotoxic systemic therapy still being the most effective treatment in BTC, except for surgery. Thus, this study aimed to analyze the role of DKK1 or β-catenin as a prognostic factor in BTC and determine the clinical association of ß-catenin and DKK1 with CD8+ tumor-infiltrating lymphocyte (TIL). Methods: We used data in The Cancer Genome Atlas (TCGA) Research Network and the clinicopathological data of 145 patients with BTC who had undergone primary radical resection between 2006 and 2016. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections, and whole tissue sections of representative tumor samples were used for antigen retrieval. Results: CD8+TIL expression was a significant predictor of favorable overall survival (OS) and recurrence-free survival (RFS) (median OS, 34.9months in TIL-high, 16.7months in TIL-low, P < 0.0001 respectively; median RFS, 27.1months in TIL-high, 10months in TIL-low, P < 0.0001 respectively). Positive ß-catenin expression and high DKK1 expression was also associated with a shorter OS (median OS, 23.95months in positive ß-catenin, 26.1months in negative ß-catenin, P = 0.1009 respectively; median OS, 19.4months in high DKK1, 31.65months in Low DKK1, P = 0.0093 respectively), but not RFS (p = 0.1466, at ß-catenin respectively; p = 0.2924, in DKK1 respectively). In the CD8+TIL-high BTC group, the tumor expression of β-catenin and DKK1 had a significant negative impact on either OS or RFS (p = 0.0146 and p = 0.0112, at ß-catenin respectively; p = 0.0950 and p = 0.3904, in DKK1 respectively). However, in the TIL-low BTC group, there were no differences in OS or RFS according to ß-catenin and DKK1 expression (p = 0.5108 and p = 0.8431, at ß-catenin respectively; p = 0.1127 and p = 0.1095, in DKK1 respectively). Cox regression multivariate analysis demonstrated that CD8+ TIL (hazard ratio [HR], 0.490; 95% confidence interval (CI), 0.303-0.791; p = 0.004) and β-catenin (HR, 1.652; 95% CI, 1.035-2.639; p = 0.036) retained significant association with OS after adjustment for all variables. Conclusions: Among patients with resected BTC, β-catenin and DKK1 protein levels are associated with poor clinical outcomes, whereas high CD8+ TIL levels are associated with good clinical outcomes. This confirms the differential clinical role of Wnt/β-catenin and DKK1 proteins according to TIL expression in BTC.

scholarly journals Expression of insulin-like growth factor I receptor as a biomarker for predicting prognosis in biliary tract cancer patients

2015 ◽  
Vol 3 (3) ◽  
pp. 464-470 ◽  
Author(s):  
HIDEO SUZUKI ◽  
JUAN C. ROA ◽  
TORU KAWAMOTO ◽  
KAZUNORI ISHIGE ◽  
IGNACIO I. WISTUBA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Patients ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Insulin Like Growth Factor ◽  
Tract Cancer ◽  
Factor I ◽  
Growth Factor I

scholarly journals Signaling pathways as therapeutic targets in biliary tract cancer

2017 ◽  
Vol 21 (5) ◽  
pp. 485-498 ◽  
Author(s):  
Jennifer Yang ◽  
Matthew R. Farren ◽  
Daniel Ahn ◽  
Tanios Bekaii-Saab ◽  
Gregory B. Lesinski
Keyword(s):  
Signaling Pathways ◽  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Therapeutic Targets ◽  
Tract Cancer

scholarly journals Prognostic role of programmed death-ligand 1 expression in patients with biliary tract cancer: a meta-analysis

Aging ◽  
2019 ◽  
Vol 11 (24) ◽  
pp. 12568-12580
Author(s):  
Changjiang Lei ◽  
Xiulan Peng ◽  
Xiaojun Gong ◽  
Ying Fan ◽  
Shenglin Wu ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Biliary Tract Cancer ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Programmed Death Ligand 1 ◽  
Tract Cancer ◽  
Programmed Death
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