Effect of Hypoxia on Hippocampal Afterdischarges in Young Rats

1991 ◽  
pp. 171-173
Author(s):  
D. Marešová ◽  
P. Mareš
Keyword(s):  
Young Rats

On the Fibrinolytic System in Aged Rats, and Its Reactivity to Endotoxin and Cytokines

1992 ◽  
Vol 67 (06) ◽  
pp. 697-701 ◽  
Author(s):  
J J Emeis ◽  
A Brouwer ◽  
R J Barelds ◽  
M A Horan ◽  
S K Durham ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Fibrinolytic Activity ◽  
Fibrinolytic System ◽  
Tissue Type ◽  
High Dose ◽  
Base Line ◽  
Aged Rats ◽  
Tissue Type Plasminogen Activator ◽  
Young Rats ◽  
Type Plasminogen Activator

SummaryAged rats are more susceptible to endotoxin-induced effects, including microthrombosis and platelet aggregation, than are young rats. To investigate whether changes in the fibrinolytic system might be involved, we investigated the fibrinolytic activity in plasma euglobulin fractions and tissues (lung and heart) of young (6-months old) and aged (24-months old) rats under baseline conditions and after challenge with endotoxin. Aged rats had lower plasma levels of tissue-type plasminogen activator (t-PA) and of urokinase-type PA (u-PA) activity. PA inhibitor (PAI) activity was higher in the plasma of aged rats, as was t-PA activity in lung and heart.Rats were treated with either a low dose (1 μg/kg) or a high dose (10 mg/kg) of endotoxin. Both treatments induced a transient phase of increased blood fibrinolytic activity, as evidenced by higher levels of tissue-type plasminogen activator (t-PA) activity and decreased levels of PA inhibitor (PAI) activity. Over time, the fibrinolytic activity decreased, probably due to increased levels of PA inhibitor.Both the early increase in t-PA activity, and the subsequent increase in PAI activity, were more pronounced in the aged rats, as compared with the younger rats, after the high dose of endotoxin. The aged rats also responded to an injection of interleukin-1β or tumor necrosis factor-α with a larger increase of PAI activity than did the younger rats.Together the data suggest that, compared to young rats, aged rats have a decreased base-line plasma fibrinolytic activity, while their fibrinolytic system is more responsive to challenge by endotoxin and cytokines.

Effect of KH-305 on the Nitric Oxide Synthase Activity and Erectile Dysfunction in Young Rats

2007 ◽  
Vol 36 (3) ◽  
pp. 305-310 ◽  
Author(s):  
Eun-Jeong Lee ◽  
Hee-Seok Kim ◽  
Byoung-Chul Kim ◽  
Sung-Wan Hwang ◽  
Sung-Yeoun Hwang
Keyword(s):  
Nitric Oxide ◽  
Erectile Dysfunction ◽  
Nitric Oxide Synthase ◽  
Young Rats ◽  
Oxide Synthase ◽  
Nitric Oxide Synthase Activity

scholarly journals EFFECTS OF INCREASED ENDOBRONCHIAL PRESSURE, VITAMIN A DEFICIENT DIETS, AND NASOPHARYNGEAL INSTALLATIONS OF BACTERIA ON THE TRACHEOBRONCHIAL TREES OF YOUNG RATS

1952 ◽  
Vol 24 (1) ◽  
pp. 80-87
Author(s):  
James F. O'Neill ◽  
H.H. Bradshaw ◽  
Felda Hightower ◽  
D.E. Ward
Keyword(s):  
Vitamin A ◽  
Young Rats

Acute hypermethioninemia impairs redox homeostasis and acetylcholinesterase activity in the hippocampus, striatum, and cerebellum of young rats

2021 ◽  
Author(s):  
Bernardo Moraes Meine ◽  
Natália Pontes Bona ◽  
Karina Pereira Luduvico ◽  
Luiza Spohr ◽  
Nathalia Stark Pedra ◽  
...  
Keyword(s):  
Redox Homeostasis ◽  
Acetylcholinesterase Activity ◽  
Young Rats
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