Role of cAMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure

1998 ◽  
pp. 153-167
Author(s):  
Louis A. Mulieri ◽  
B. J. Leavitt ◽  
R. K. Wright ◽  
N. R. Alpert
Keyword(s):  
Heart Failure ◽  
Mitral Regurgitation ◽  
Force Frequency ◽  
Relaxation Kinetics ◽  
Frequency Relation

Role of cAMP in modulating relaxation kinetics and the force-frequency relation in mitral regurgitation heart failure

1997 ◽  
Vol 92 (S1) ◽  
pp. 95-103 ◽  
Author(s):  
L. A. Mulieri ◽  
B. J. Leavitt ◽  
R. K. Wright ◽  
N. R. Alpert
Keyword(s):  
Heart Failure ◽  
Mitral Regurgitation ◽  
Force Frequency ◽  
Relaxation Kinetics ◽  
Frequency Relation

scholarly journals Dynamic control of maximal ventricular elastance via the baroreflex and force-frequency relation in awake dogs before and after pacing-induced heart failure

2010 ◽  
Vol 299 (1) ◽  
pp. H62-H69 ◽  
Author(s):  
Xiaoxiao Chen ◽  
Javier A. Sala-Mercado ◽  
Robert L. Hammond ◽  
Masashi Ichinose ◽  
Soroor Soltani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Transfer Function ◽  
Transfer Functions ◽  
Dynamic Properties ◽  
System Response ◽  
Force Frequency ◽  
Arterial Baroreflex ◽  
Ventricular Elastance ◽  
Arterial Blood ◽  
Frequency Relation

We investigated to what extent maximal ventricular elastance ( Emax) is dynamically controlled by the arterial baroreflex and force-frequency relation in conscious dogs and to what extent these mechanisms are attenuated after the induction of heart failure (HF). We mathematically analyzed spontaneous beat-to-beat hemodynamic variability. First, we estimated Emax for each beat during a baseline period using the ventricular unstressed volume determined with the traditional multiple beat method during vena cava occlusion. We then jointly identified the transfer functions (system gain value and time delay per frequency) relating beat-to-beat fluctuations in arterial blood pressure (ABP) to Emax (ABP→ Emax) and beat-to-beat fluctuations in heart rate (HR) to Emax (HR→ Emax) to characterize the dynamic properties of the arterial baroreflex and force-frequency relation, respectively. During the control condition, the ABP→ Emax transfer function revealed that ABP perturbations caused opposite direction Emax changes with a gain value of −0.023 ± 0.012 ml−1, whereas the HR→ Emax transfer function indicated that HR alterations caused same direction Emax changes with a gain value of 0.013 ± 0.005 mmHg·ml−1·(beats/min)−1. Both transfer functions behaved as low-pass filters. However, the ABP→ Emax transfer function was more sluggish than the HR→ Emax transfer function with overall time constants (indicator of full system response time to a sudden input change) of 11.2 ± 2.8 and 1.7 ± 0.5 s ( P < 0.05), respectively. During the HF condition, the ABP→ Emax and HR→ Emax transfer functions were markedly depressed with gain values reduced to −0.0002 ± 0.007 ml−1 and −0.001 ± 0.004 mmHg·ml−1·(beats/min)−1 ( P < 0.1). Emax is rapidly and significantly controlled at rest, but this modulation is virtually abolished in HF.

scholarly journals Force-frequency relation in human heart failure.

Circulation ◽  
1992 ◽  
Vol 86 (6) ◽  
pp. 2017-2018 ◽  
Author(s):  
R H Schwinger ◽  
M Böhm ◽  
A Koch ◽  
E Erdmann
Keyword(s):  
Heart Failure ◽  
Human Heart ◽  
Force Frequency ◽  
Human Heart Failure ◽  
Frequency Relation

scholarly journals Myocardial force-frequency defect in mitral regurgitation heart failure is reversed by forskolin.

Circulation ◽  
1993 ◽  
Vol 88 (6) ◽  
pp. 2700-2704 ◽  
Author(s):  
L A Mulieri ◽  
B J Leavitt ◽  
B J Martin ◽  
J R Haeberle ◽  
N R Alpert
Keyword(s):  
Heart Failure ◽  
Mitral Regurgitation ◽  
Force Frequency

scholarly journals Calcium Sensitivity, Force Frequency Relation and Cardiac Troponin I: Critical Role of PKA and PKC Phosphorylation Sites

2010 ◽  
Vol 98 (3) ◽  
pp. 356a
Author(s):  
Genaro A. Ramirez-Correa ◽  
Sonia Cortassa ◽  
Brian Stanley ◽  
Wei Dong Gao ◽  
Anne M. Murphy
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Critical Role ◽  
Calcium Sensitivity ◽  
Cardiac Troponin I ◽  
Phosphorylation Sites ◽  
Force Frequency ◽  
Frequency Relation
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