Can New Vaccines Overcome Parasite Escape Mechanisms?

1993 ◽  
pp. 683-689
Author(s):  
P.-H. Lambert ◽  
J. A. Louis ◽  
G. Del Giudice
Keyword(s):  
New Vaccines

Immunization: Programming for New Vaccines

2004 ◽  
Author(s):  
David Allison
Keyword(s):  
New Vaccines

Moving past the vaccine/autism controversy - to examine potential vaccine neurological harms

2020 ◽  
pp. 1-15
Author(s):  
Peter R. Breggin
Keyword(s):  
Neurological Disorders ◽  
Developmental Disorder ◽  
Physical Symptoms ◽  
Psychosocial Disorders ◽  
The Us ◽  
Potential Vaccine ◽  
Research And Education ◽  
The Brain ◽  
New Vaccines

BACKGROUND: The vaccine/autism controversy has caused vast scientific and public confusion, and it has set back research and education into genuine vaccine-induced neurological disorders. The great strawman of autism has been so emphasized by the vaccine industry that it, and it alone, often appears in authoritative discussions of adverse effects of the MMR and other vaccines. By dismissing the chimerical vaccine/autism controversy, vaccine defenders often dismiss all genuinely neurological aftereffects of the MMR (measles, mumps, and rubella) and other vaccines, including well-documented events, such as relatively rare cases of encephalopathy and encephalitis. OBJECTIVE: This report explains that autism is not a physical or neurological disorder. It is not caused by injury or disease of the brain. It is a developmental disorder that has no physical origins and no physical symptoms. It is extremely unlikely that vaccines are causing autism; but it is extremely likely that they are causing more neurological damage than currently appreciated, some of it resulting in psychosocial disabilities that can be confused with autism and other psychosocial disorders. This confusion between a developmental, psychosocial disorder and a physical neurological disease has played into the hands of interest groups who want to deny that vaccines have any neurological and associated neuropsychiatric effects. METHODS: A review of the scientific literature, textbooks, and related media commentary is integrated with basic clinical knowledge. RESULTS: This report shows how scientific sources have used the vaccine/autism controversy to avoid dealing with genuine neurological risks associated with vaccines and summarizes evidence that vaccines, including the MMR, can cause serious neurological disorders. Manufacturers have been allowed by the US Food and Drug Administration (FDA) to gain vaccine approval without placebo-controlled clinical trials. CONCLUSIONS: The misleading vaccine autism controversy must be set aside in favor of examining actual neurological harms associated with vaccines, including building on existing research that has been ignored. Manufacturers of vaccines must be required to conduct placebo-controlled clinical studies for existing vaccines and for government approval of new vaccines. Many probable or confirmed neurological adverse events occur within a few days or weeks after immunization and could be detected if the trials were sufficiently large. Contrary to current opinion, large, long-term placebo-controlled trials of existing and new vaccines would be relatively easy and safe to conduct.

Immunizations and vaccines: a decade of successes and reversals, and a call for ‘vaccine diplomacy’

2019 ◽  
Vol 11 (5) ◽  
pp. 331-333 ◽  
Author(s):  
Peter J Hotez
Keyword(s):  
Respiratory Virus ◽  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Virus Infections ◽  
Vaccination Programs ◽  
Vaccine Preventable Diseases ◽  
Health Gains ◽  
Potential Development ◽  
Respiratory Virus Infections ◽  
New Vaccines

Abstract Over the last decade we have seen extraordinary public health gains due to expansions in global vaccination programs led by United Nations (UN) agencies, including Gavi, the Vaccine Alliance, UNICEF and the WHO. These initiatives have reduced childhood deaths from measles, tetanus and other vaccine-preventable diseases by almost one half. There is additional excitement over the potential development and introduction of new vaccines to prevent highly lethal respiratory virus infections, as well as tuberculosis, malaria, HIV/AIDS and several neglected tropical diseases. However, these successes are under threat due to political instability, conflict and an accelerating antivaccine movement. New initiatives in vaccine diplomacy will be required to combat these challenges.

Comparative genomics of Bordetella pertussis and prediction of new vaccines and drug targets

2021 ◽  
pp. 1-17
Author(s):  
Andrei G. Felice ◽  
Leonardo N. Q. Santos ◽  
Ian Kolossowski ◽  
Felipe L. Zen ◽  
Leandro G. Alves ◽  
...  
Keyword(s):  
Comparative Genomics ◽  
Bordetella Pertussis ◽  
Drug Targets ◽  
New Vaccines

Two new vaccines deliver good and bad news for the pandemic

Science ◽  
2021 ◽  
Vol 371 (6529) ◽  
pp. 548-549
Author(s):  
Jon Cohen
Keyword(s):  
Bad News ◽  
New Vaccines

scholarly journals Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 263
Author(s):  
Valéria L. Carvalho ◽  
Maureen T. Long
Keyword(s):  
Clinical Trials ◽  
Current Status ◽  
Wild Type ◽  
New Locations ◽  
The Creation ◽  
New Vaccines

Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs.

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