Intermittent Dose Schedule of Retinoids (Ro 10-9359) for Long-term follow-up on Psoriasis (Preliminary Report)

SummaryThree hemophiliacs with high titre inhibitor were treated with a medium-high FVIII dose schedule (100 IU/kg bw daily) with the aim of inducing the immunotolerance. These patients were followed-up extensively concerning their immunological status and HIV serology. In all of them the inhibitor disappeared and normal FVIII kinetics were obtained after 22, 15 and 29 months. After eradication of the inhibitor, no recurrence took place in any of the patients. All the patients were HIV Ab positive before the beginning of the treatment. In one of them CD4+ cells fell progessively 32 months after the treatment was started, a fullblown AIDS showed up, and the patient died 5½ years after the beginning of the treatment. In the second and third patient the CD4+ cells varied widely but remained >400/μl during the whole immunotolerance treatment. The latter two patients are AIDS and ARC free so far, but patient No. 2 developed a mild-to-severe thrombocytopenia.Considering the high cost of the treatment and the possibility that such an intensive administration of FVIII concentrates might worsen the immunological status of patients, this therapeutic procedure should only be applied with caution.

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A Preliminary Report on Treatment of Contact Granuloma With Steroid Injections

American Journal of Speech-Language Pathology ◽

10.1044/1058-0360.0702.92 ◽

1998 ◽

Vol 7 (2) ◽

pp. 92-96 ◽

Cited By ~ 1

Author(s):

Michael A. Crary ◽

Christine M. Sapienza ◽

Nicholas J. Cassisi ◽

G. Paul Moore

Keyword(s):

Preliminary Report ◽

Steroid Injection ◽

Post Injection ◽

Post Intervention ◽

Steroid Injections ◽

Voice Treatment ◽

Long Term Follow Up ◽

Local Steroid Injection

This preliminary report discusses the effects of intralesion local steroid injection for treatment of contact granulomas. Four men between the ages of 39 and 59 years and one woman age 33 years, who were diagnosed with contact granulomas and who failed previous management attempts, are discussed. Intralesion steroid injections of triamcinolone were completed in an otolaryngology outpatient clinic. Results showed that the size of contact granulomas was reduced with injection of the steroid in all five patients. Contact granuloma was completely eliminated in one patient. Furthermore, all patients were clinically asymptomatic 3 to 4 months post-injection, although only two of the five granulomas were totally eliminated at the time of long-term follow-up. Clinical improvement was confirmed by direct laryngoscopic evaluation of contact granuloma size 4 months following completion of the steroid injections. A speech-language pathologist's knowledge of this technique may prevent patients with granuloma from enduring protracted voice treatment that is historically less effective. The speech-language pathologist's responsibilities include determining patient candidacy for intralesion steroid injection, assisting the otolaryngologist with endoscopic interpretation of the lesion pre- and post-intervention, and tracking the clinical outcome of the procedure.

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Re-evaluation of differential sacral rhizotomy for neurological bladder disease

Journal of Neurosurgery ◽

10.3171/jns.1978.48.5.0773 ◽

1978 ◽

Vol 48 (5) ◽

pp. 773-778 ◽

Cited By ~ 17

Author(s):

Gaylan L. Rockswold ◽

Shelley N. Chou ◽

William E. Bradley

Keyword(s):

Preliminary Report ◽

Urgency Incontinence ◽

Content Type ◽

Bladder Disease ◽

Long Term Follow Up ◽

Alternative Approaches ◽

Neurological Bladder ◽

Fine Print

✓ The authors describe long-term follow-up results (4 to 6 years) in 13 patients who underwent differential sacral rhizotomy for urgency incontinence. Six patients were originally presented in a preliminary report in 1973. In the last seven patients, a highly selective rhizotomy of sacral fascicles innervating only the urinary bladder was performed. Results in the original six patients appear to be superior to those in patients who underwent a more refined rhizotomy. Possible explanations for this as well as alternative approaches to the treatment of urgency incontinence are briefly discussed.

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