An Improved Recommender System Solution to Mitigate the Over-Specialization Problem Using Genetic Algorithms

Nowadays, recommendation systems offer a method of facilitating the user’s desire. It is useful for recommending items from a variety of areas such as in the e-commerce, medical, education, tourism, and industry domains. The e-commerce area represents the most active research we found, which assists users in locating the things they want. A recommender system can also provide users with helpful knowledge about things that could be of interest. Sometimes, the user gets bored with recommendations which are similar to their profiles, which leads to the over-specialization problem. Over-specialization is caused by limited content data, under which content-based recommendation algorithms suggest goods directly related to the customer profile rather than new things. In this study, we are particularly interested in recommending surprising, new, and unexpected items that may likely be enjoyed by users and will mitigate this limited content. In order to recommend novel and serendipitous items along with familiar items, we need to introduce additional hacks and note of randomness, which can be achieved using genetic algorithms that brings diversity to recommendations being made. This paper describes a Revolutionary Recommender System using a Genetic Algorithm called RRSGA which improves the fitness functions for recommending optimal results. The proposed approach employs a genetic algorithm to address the over-specialization issue of content-based filtering. The proposed method aims to incorporate genetic algorithms that bring variety to recommendations and efficiently adjust and suggest unpredictable and innovative things to the user. Experiments objectively demonstrate that our technology can recommend additional products that every consumer is likely to appreciate. The results of RRSGA have been compared against recommendation results from the content-based filtering approach. The results indicate the effectiveness of RRSGA and its capacity to make more accurate predictions than alternative approaches.

Protecting against researcher bias in secondary data analysis: challenges and potential solutions

Analysis of secondary data sources (such as cohort studies, survey data, and administrative records) has the potential to provide answers to science and society’s most pressing questions. However, researcher biases can lead to questionable research practices in secondary data analysis, which can distort the evidence base. While pre-registration can help to protect against researcher biases, it presents challenges for secondary data analysis. In this article, we describe these challenges and propose novel solutions and alternative approaches. Proposed solutions include approaches to (1) address bias linked to prior knowledge of the data, (2) enable pre-registration of non-hypothesis-driven research, (3) help ensure that pre-registered analyses will be appropriate for the data, and (4) address difficulties arising from reduced analytic flexibility in pre-registration. For each solution, we provide guidance on implementation for researchers and data guardians. The adoption of these practices can help to protect against researcher bias in secondary data analysis, to improve the robustness of research based on existing data.

Trained Immunity-Based Vaccines: A Ready-to-Act Strategy to Tackle Viral Outbreaks

Viral outbreaks have become significant threats to global human public health. New emerging viruses, pathogen mutations, and even the progressive loss of efficacy in some existing vaccines are behind this problem, which is amplified by the rapid virus spread given the ease of current mobility. Taking into account that these outbreaks arise in the absence of conventional effective vaccines, alternative approaches based on trained (innate) immunity are being considered. This immunity is dependent on a functional reprogramming of innate immune cells, leading to an enhanced nonspecific response towards different pathogens, including viruses. Trained immunity-based vaccines (TIbVs), defined as vaccine formulations containing trained immunity inducers, could be used during viral outbreaks to confer non-specific protection but also to enhance adaptive specific immune responses. In this chapter, we aim to illustrate how TIbVs could tackle the above-mentioned situations derived from viral outbreaks, reviewing the potential of available TIbVs in such urgent situations with a special mention to COVID-19.

Characterization of Lacticaseibacillus rhamnosus, Levilactobacillus brevis and Lactiplantibacillus plantarum Metabolites and Evaluation of Their Antimicrobial Activity against Food Pathogens

Lactic acid bacteria (LAB) play an important role as natural food preservatives. However, the characterization of the variety of their metabolites is limited. The objective of this study was to determine the production of specific metabolites of Lacticaseibacillus rhamnosus, Levilactobacillus brevis and Lactiplantibacillus plantarum by an optimized liquid chromatography with an ultraviolet/diode detection (HPLC-UV/DAD) method and to investigate their potential antimicrobial activity against specific food pathogens. Based on the results of this study, the main metabolites detected in Levilactobacillus brevis were 103.4 μg mL−1 DL-p-Hydroxyphenyllactic acid (OH-PLA) and 2.59 μg mL−1 vanillic acid, while 216.2 μg mL−1 OH-PLA, 19.0 μg mL−1 salicylic acid, 3.7 μg mL−1 vanillic acid, 6.9 μg mL−1 ferulic acid, 4.2 μg mL−1 benzoic acid and 1.4 μg mL−1 4-Hydrocinnamic acid were identified in the Lactiplantibacillus plantarum strain and 147.6 μg mL−1 OH-PLA and 4.9 μg mL−1 ferulic acid were identified in Lacticaseibacillus rhamnosus. This study provides alternative approaches for the molecules involved in the antimicrobial activity of food microorganism fermentation. These molecules may be used as antimicrobial ingredients in the food industry instead of conventional chemical preservatives.

Salt-free Chromium Tanning: Practical Approaches

Chromium tanning finds a prominant place in leather manufacturing for permanent stabilization of hide/skin matrix. Though, it has multiple advantages in terms of high thermal stability, easy process and low cost etc., the current practice is not environmentally sustainable. Poor chromium exhaustion and TDS load generation are the major environmental threats of conventional chromium tanning systems. On the other hand, salt-free chromium tanning is identified as one of the efficient alternative approaches for hide/skin matrix stabilization. However, it has not been commercially practiced due to the several practical difficulties. In this work attempts have been made to develop a practically viable high-performance salt-free chromium tanning system using deliming liquor as tanning float and changing the order of addition of masking salt. The developed methodologies completely avoid the use of salt/basification process and it is suitable for all kinds of raw materials and tannery houses. Besides, the process enjoys 71-77% reduction in TDS load and the uptake of chromium is around 90%. The physical strength characteristics are on par with conventional process and the leathers exhibit good grain tightness and roundness. The developed methodologies are simple and do not require any specialty chemicals.

Ionic liquid enables the preparation of copper-loaded gel with transdermal delivery function for wound dressings

Antimicrobial resistant pathogens infections motivate the exploration of alternative approaches to treat bacterial infections. Copper ions (Cu2+) have been involved in sterilization, however, its direct use may cause high local...

Learning From Our Ancestors

This chapter reflects on the challenges of criterion-referenced final examinations in higher education within the context of Micronesian cultural realities and suggests alternative approaches that may contribute more constructively to student success. The first explores the transformative role that mentor relationships can have on both student engagement and purposeful and meaningful faculty-student interaction. The second appreciates the powerful contribution that connectivity plays as professors work to create a community of scholars within their university courses. And finally, the authors highlight the value of publishing as a pedagogic tool within a university course that elevates the process of research and writing making the work all the more important and meaningful to students. All three approaches are particularly meaningful due to the cultural relevance of each to Micronesian people.

Alternative Approaches to The Reform of Higher Education: Manageralism VS. New Public Service

The article is devoted to the analysis of alternative approaches applicable to modern reform of higher education. Last three decades, the set of management technologies of the new public management (NPM) has significantly transformed higher education, introducing application some elements of quasi-markets and metric systems of performance indicators. Their large-scale use was reinforced by the ideology of new manageralism, which builds confidence among managers in effectiveness of their application in higher education. However, the experience of their practical implementation has given rise to negative effects and problems associated with emergence of institutional traps. These traps have become serious obstacles to development of modern higher education. The possible alternative when adjusting development in this sphere can be the concept of “the new public service”, which has been implemented in recent years within civil service reform. This new approach is based on cultivating the set of ethical values and principles that promote openness, transparency, democracy and cooperation between bureaucrats and consumers of public services. Due to some specifics of professional activity in the academic environment, its principles and values can be successfully applied in higher education too. The article offers an interpretation of application of this approach in the context of expanding project education and cultivating key values of the academic community in context of management of higher education.

An Agenda for Future Research in Forensic Economics: New Approaches to Viewing Controversial Topics

Despite a large body of published research in forensic economics, there are still controversial topics that are lacking consensus. This paper presents an agenda for research on controversial topics in the hope that the results of such research will improve the reliability and validity of the work of forensic economists. Specifically, the paper presents suggestions for research on the choice of interest rates for discounting; interest rates, earnings growth and inflation; interest rates, growth in medical costs and inflation; how many years of earnings history is necessary to project base earnings and earnings history; alternative approaches to hedonic damages; and punitive damages.