In the small-plot experiment of the Russian State Agrarian University - Moscow Timiryazev Agricultural Academy against potato viruses in 2014-2019 were tested some kinds of preparations with antiviral activity: Pharmayod, GS (100 g/l of iodine); Immunocytophyte, TAB (20 g/kg arachidonic acid ethyl ester); Ecogel, WS (30 g/l of chitosan lactate); Amulet, TAB (composition of linear polyaminosaccharides (chitosan) in succinic acid solution); Zerox, WS (3000 mg /l colloidal silver); Viron, WS (biostimulant based on urea and citric acid with the addition of essential oils). According to the results of the studies, it was found that, in addition to the effect on the causative agents of viral diseases of potatoes, all tested preparations had a stable tendency to maintain or increase the yield of tubers of infected plants. The increase in the yield of tubers ranged from 0.5 to 1.3 kg/m2. In 2016 under the production conditions of Astrakhan region on the potato variety Impala infected with the PVM + PVS and PVM + PVS + PVY virus complexes a comparative assessment of the effect of Pharmayod and Immunocytophyte revealed a significant increase in the gross and marketable yield of potato plants in the areas with the use of these preparations compared to with control.