Suppressive Effect of Interferon Alpha-2b on Hemopoietic Progenitor Cells in Patients with Chronic Myelogenous Leukemia

1988 ◽  
pp. 84-90
Author(s):  
U. B. Wandl ◽  
O. Kloke ◽  
B. Opalka ◽  
N. Niederle
Keyword(s):  
Progenitor Cells ◽  
Chronic Myelogenous Leukemia ◽  
Interferon Alpha ◽  
Suppressive Effect ◽  
Myelogenous Leukemia ◽  
Interferon Alpha 2B ◽  
Hemopoietic Progenitor ◽  
Hemopoietic Progenitor Cells

scholarly journals Interferon alpha-2b as therapy for Ph'-positive chronic myelogenous leukemia: a study of 82 patients treated with intermittent or daily administration

Blood ◽  
1988 ◽  
Vol 72 (2) ◽  
pp. 642-647 ◽  
Author(s):  
G Alimena ◽  
E Morra ◽  
M Lazzarino ◽  
AM Liberati ◽  
E Montefusco ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Interferon Alpha ◽  
Response Rate ◽  
Cytogenetic Response ◽  
Myelogenous Leukemia ◽  
Complete Suppression ◽  
Recombinant Interferon ◽  
Hematologic Response ◽  
Interferon Alpha 2B ◽  
Ifn Alpha

The authors treated a total of 82 patients with Ph′-positive chronic myelogenous leukemia (CML) with recombinant interferon alpha-2b (IFN alpha-2b). Sixty-five patients in chronic phase (CP), 28 of whom were untreated and 37 pretreated, and nine patients in accelerated phase (AP), were started on IFN three times a week. Patients in CP were randomized to receive 2 or 5 X 10(6) IU/m2, while patients in AP were all given the dose of 5 X 10(6) IU/m2, in addition to concomitant chemotherapy. Patients in CP who were unresponsive to the lower dose were crossed to the higher dose. Of 63 evaluable patients in CP, 43 (68%) responded, 29 (46%) achieved complete hematologic response (CHR), and 14 (22%) achieved partial hematologic response (PHR). The response rate appeared to be significantly influenced by the IFN dose in pretreated patients. Of the nine patients in AP, two attained PHR and one CHR. More recently, eight previously untreated CP cases were submitted to daily IFN administration at doses from 2 to 5 X 10(6) IU/m2. This daily schedule was also applied to patients who had obtained, with the intermittent treatment, a PHR persisting unmodified for six months (nine patients) or an unstable CHR (five patients). Seven of the eight previously untreated patients, and five of the nine PHR patients crossed to daily IFN reached CHR. In the total series of previously untreated patients, the response rate proved to be significantly influenced by the initial risk status. Cytogenetic improvement was seen in 37 of 53 responders (70%) treated for more than 3 months, the median of Ph′-positive cells declining from 100% to 65% (range 0% to 95%). Complete suppression of Ph′ chromosome was observed in one case. The cytogenetic response was persistent for over 6 months in 21 patients, but the lowest value of Ph′ positivity was usually unstable. At a median follow-up of 56 weeks, 23 of 36 (64%) CHR patients remain in continued disease control with IFN. A blastic transformation (BT) occurred in seven of 21 unresponsive patients and in one of the 36 CHR patients. The authors' data confirm that IFN alpha- 2b, especially at daily doses, is effective in inducing clinical and cytogenetic response in a good proportion of patients with CML in the benign phase. Longer follow-ups will define the exact influence of this agent on the natural course of the disease.

Results of a phase II trial testing interferon-alpha 2b and cytarabine in children and adolescents with chronic myelogenous leukemia

2006 ◽  
Vol 47 (5) ◽  
pp. 555-559 ◽  
Author(s):  
Frédéric Millot ◽  
Joelle Guilhot ◽  
Brigitte Nelken ◽  
Thierry Leblanc ◽  
Guy Leverger ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Chronic Myelogenous Leukemia ◽  
Interferon Alpha ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Myelogenous Leukemia ◽  
Interferon Alpha 2B ◽  
Trial Testing

Interferon alpha-2b as therapy for patients with Ph‘-positive chronic myelogenous leukemia

2009 ◽  
Vol 45 (S52) ◽  
pp. 25-28 ◽  
Author(s):  
Giuliana Alimena ◽  
Enrica Morra ◽  
Mario Lazzarino ◽  
Anna M. Liberati ◽  
Enrico Montefusco ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Interferon Alpha ◽  
Myelogenous Leukemia ◽  
Interferon Alpha 2B

Acral Sclerosis due to Interferon-Alpha-2b in Chronic Myelogenous Leukemia

2002 ◽  
Vol 107 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Guray Saydam ◽  
Devrim Bozkurt ◽  
Fahri Sahin ◽  
Safak Yuksel ◽  
Mine Hekimgil ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Interferon Alpha ◽  
Myelogenous Leukemia ◽  
Interferon Alpha 2B

scholarly journals Interferon alpha-2b as therapy for Ph'-positive chronic myelogenous leukemia: a study of 82 patients treated with intermittent or daily administration

Blood ◽  
1988 ◽  
Vol 72 (2) ◽  
pp. 642-647 ◽  
Author(s):  
G Alimena ◽  
E Morra ◽  
M Lazzarino ◽  
AM Liberati ◽  
E Montefusco ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Interferon Alpha ◽  
Response Rate ◽  
Cytogenetic Response ◽  
Myelogenous Leukemia ◽  
Complete Suppression ◽  
Recombinant Interferon ◽  
Hematologic Response ◽  
Interferon Alpha 2B ◽  
Ifn Alpha

Abstract The authors treated a total of 82 patients with Ph′-positive chronic myelogenous leukemia (CML) with recombinant interferon alpha-2b (IFN alpha-2b). Sixty-five patients in chronic phase (CP), 28 of whom were untreated and 37 pretreated, and nine patients in accelerated phase (AP), were started on IFN three times a week. Patients in CP were randomized to receive 2 or 5 X 10(6) IU/m2, while patients in AP were all given the dose of 5 X 10(6) IU/m2, in addition to concomitant chemotherapy. Patients in CP who were unresponsive to the lower dose were crossed to the higher dose. Of 63 evaluable patients in CP, 43 (68%) responded, 29 (46%) achieved complete hematologic response (CHR), and 14 (22%) achieved partial hematologic response (PHR). The response rate appeared to be significantly influenced by the IFN dose in pretreated patients. Of the nine patients in AP, two attained PHR and one CHR. More recently, eight previously untreated CP cases were submitted to daily IFN administration at doses from 2 to 5 X 10(6) IU/m2. This daily schedule was also applied to patients who had obtained, with the intermittent treatment, a PHR persisting unmodified for six months (nine patients) or an unstable CHR (five patients). Seven of the eight previously untreated patients, and five of the nine PHR patients crossed to daily IFN reached CHR. In the total series of previously untreated patients, the response rate proved to be significantly influenced by the initial risk status. Cytogenetic improvement was seen in 37 of 53 responders (70%) treated for more than 3 months, the median of Ph′-positive cells declining from 100% to 65% (range 0% to 95%). Complete suppression of Ph′ chromosome was observed in one case. The cytogenetic response was persistent for over 6 months in 21 patients, but the lowest value of Ph′ positivity was usually unstable. At a median follow-up of 56 weeks, 23 of 36 (64%) CHR patients remain in continued disease control with IFN. A blastic transformation (BT) occurred in seven of 21 unresponsive patients and in one of the 36 CHR patients. The authors' data confirm that IFN alpha- 2b, especially at daily doses, is effective in inducing clinical and cytogenetic response in a good proportion of patients with CML in the benign phase. Longer follow-ups will define the exact influence of this agent on the natural course of the disease.

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