Molecular Diversity in Signal Transducing G-Proteins

1993 ◽  
pp. 151-158
Author(s):  
L. Birnbaumer
Keyword(s):  
G Proteins ◽  
Molecular Diversity

scholarly journals Molecular Diversity and Function of G Proteins and Calcium Channels1

1991 ◽  
Vol 44 (2) ◽  
pp. 207-224 ◽  
Author(s):  
Lutz Birnbaumer ◽  
Edward Perez-Reyes ◽  
Philippe Bertrand ◽  
Thomas Gudermann ◽  
Xiang-Yang Wei ◽  
...  
Keyword(s):  
G Proteins ◽  
Molecular Diversity ◽  
And Function

scholarly journals New insights into the families of PLC enzymes: looking back and going forward

2005 ◽  
Vol 391 (3) ◽  
Author(s):  
Matilda Katan
Keyword(s):  
G Proteins ◽  
Regulatory Networks ◽  
Molecular Diversity ◽  
Splice Variants ◽  
Heterotrimeric G Proteins ◽  
New Members ◽  
Protein Subunits ◽  
Biochemical Journal ◽  
Related Group ◽  
Looking Back

A study in this issue of the Biochemical Journal by Harden and colleagues, in association with one published in the Biochemical Journal very recently [Hwang, Oh, Shin, Kim, Ryu and Suh (2005) Biochem. J. 389, 181–186], have defined a new member of the superfamily of PLC (phosphoinositide-specific phospholipase C) enzymes, PLCη. Two isoforms, PLCη1 and PLCη2, and their splice variants add to the molecular diversity of PLC enzymes. The studies of PLCη regulation suggest that at least some splice variants of PLCη2 could be regulated by the G-protein subunits Gβγ. As two other families, PLCβ and PLCϵ, are also regulated through heterotrimeric G-proteins, this finding reveals further complexity and possible interplay between different PLC families and their regulatory networks. At this point, when it is likely that the PLCη family completes the effort of identifying new members of this related group of PLC enzymes, I also discuss some more general concepts of PLC regulation and catalysis, and challenges awaiting their further studies.

Presence of P2X1 Purinoceptors in Human Platelets and Megakaryoblastic Cell Lines

1997 ◽  
Vol 78 (06) ◽  
pp. 1500-1504 ◽  
Author(s):  
Catherine Vial ◽  
Béatrice Hechier ◽  
Catherine Léon ◽  
Jean-Pierre Cazenave ◽  
Christian Gachet
Keyword(s):  
Intracellular Calcium ◽  
G Proteins ◽  
Cell Lines ◽  
Calcium Influx ◽  
Human Platelets ◽  
P2y1 Receptor ◽  
Calcium Response ◽  
Ionotropic Receptors ◽  
External Calcium

SummaryHuman platelets are thought to possess at least two subtypes of purinoceptor, one of which, coupled to G-proteins, could be the P2Y1 receptor (Léon et al. 1997). However, it has been suggested that the unique rapid calcium influx induced by ADP in platelets could involve P2X1 ionotropic receptors (MacKenzie et al. 1996) and the aim of this study was thus to investigate the presence of P2X purinoceptors in platelets and megakaryoblastic cells. Using PCR experiments, we found P2X1 mRNA to be present in human platelets and megakaryoblastic cell lines. In platelets, the selective P2X1 agonist αβMeATP induced a rise in intracellular calcium only in the presence of external calcium and this effect was antagonized by suramin and PPADS. Repeated addition of a�MeATP desensitized the P2X1 purinoceptor but only slightly affected the ADP response, while no calcium response to αβMeATP was observed in megakaryoblastic cells. These results support the existence of functional P2X1 purinoceptors on human platelets and the presence of P2X1 transcripts in megakaryoblastic cell lines.

Analysis of inhibitory G-proteins Gi-alpha 2 and Gi-alpha 3 in patients supported by ventricular assist devices

2005 ◽  
Vol 53 (S 01) ◽  
Author(s):  
H Milting ◽  
A Kassner ◽  
R Brendel ◽  
L Arusoglu ◽  
R Körfer ◽  
...  
Keyword(s):  
G Proteins ◽  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices

G proteins and modulation of insulin secretion

Diabetes ◽  
1991 ◽  
Vol 40 (1) ◽  
pp. 1-6 ◽  
Author(s):  
R. P. Robertson ◽  
E. R. Seaquist ◽  
T. F. Walseth
Keyword(s):  
Insulin Secretion ◽  
G Proteins

Morphological and Molecular Diversity of Benthic Cyanobacteria Communities Versus Environmental Conditions in Shallow, High Mountain Water Bodies in Eastern Pamir Mountains (Tajikistan)

2020 ◽  
Vol 67 (4) ◽  
pp. 286 ◽  
Author(s):  
Iwona Jasser ◽  
Iwona Kostrzewska-Szlakowska ◽  
Jan Kwiatowski ◽  
Dovutsho Navruzshoev ◽  
Małgorzata Suska-Malawska ◽  
...  
Keyword(s):  
Environmental Conditions ◽  
Molecular Diversity ◽  
Water Bodies ◽  
High Mountain ◽  
Benthic Cyanobacteria ◽  
Pamir Mountains
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