Cytology and Survival in Acute Lymphatic Leukemia of Children

1973 ◽  
pp. 28-34
Author(s):  
S. L. Lee ◽  
O. Glidewell
Keyword(s):  
Acute Lymphatic Leukemia ◽  
Lymphatic Leukemia

Lymphomatoid Granulomatosis in a Child with Acute Lymphatic Leukemia in Remission

1978 ◽  
Vol 87 (5_suppl) ◽  
pp. 5-10 ◽  
Author(s):  
Seymour R. Cohen ◽  
Stuart Siegel ◽  
Eva Heuser ◽  
Benjamin H. Landing ◽  
Susan Shen ◽  
...  
Keyword(s):  
Survival Rate ◽  
Poor Prognosis ◽  
Lymphoblastic Leukemia ◽  
Lymphomatoid Granulomatosis ◽  
Unknown Etiology ◽  
Acute Lymphatic Leukemia ◽  
Clinical Onset ◽  
Lymphatic Leukemia ◽  
Trachea And Bronchi ◽  
Other Neoplasms

Lymphomatoid granulomatosis, a tumor-like process of unknown etiology, produced progressively destructive disease of the larynx, trachea and bronchi in an eight-year-old girl with acute lymphoblastic leukemia of five years duration. The leukemia had been in remission for 4½ years at the clinical onset of the lymphomatoid granulomatosis. Whether this occurrence suggests that lymphomatoid granulomatosis is a type of neoplasm, or is associated with immunologic depression, cannot be stated. Fortunately rare, and of poor prognosis, the disorder may become more frequent with improved survival rate of patients with leukemia and other neoplasms.

GENETICS IN ACUTE LYMPHATIC LEUKEMIA IN CHILDHOOD

1969 ◽  
Vol 155 (2 Polymer Scien) ◽  
pp. 777-783
Author(s):  
J. Jeffrey McCullough ◽  
Melvyn T. Korobkin ◽  
William Krivit
Keyword(s):  
Acute Lymphatic Leukemia ◽  
Lymphatic Leukemia

scholarly journals Case Report: A rare association between SLE and Acute Lymphatic Leukemia

2018 ◽  
Vol 1 (3) ◽  
pp. 01-02
Author(s):  
P.K. Sasidharan
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Past History ◽  
Lymphoblastic Leukemia ◽  
Acute Lymphatic Leukemia ◽  
Rare Association ◽  
Lymphatic Leukemia ◽  
History Of

A 30-year-old housewife with past history of acute lymphoblastic leukemia 12 years back, still in remission, was admitted with polyarthritis of 2 months duration. She was evaluated and found to have SLE with positive ANA and Anti ds DNA which were strongly positive.

scholarly journals The Functional Interplay Between the t(9;22)-Associated Fusion Proteins BCR/ABL and ABL/BCR in Philadelphia Chromosome Positive Acute Lymphatic Leukemia

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 2402-2402
Author(s):  
Afsar Mian ◽  
Anahita Rafiei ◽  
Claudia Oancea ◽  
Oliver G. Ottmann ◽  
Martin Ruthardt
Keyword(s):  
Stem Cell ◽  
Fusion Proteins ◽  
Conflicts Of Interest ◽  
Philadelphia Chromosome ◽  
Acute Lymphatic Leukemia ◽  
Abl Kinase ◽  
Lymphatic Leukemia ◽  
Syngeneic Mouse Model ◽  
Philadelphia Chromosome Positive

Abstract The successful targeting of BCR/ABL by selective ABL-kinase inhibitors (AKI) such as Imatinib, Nilotinib, or Dasatinib alone is unable to eradicate the leukemic clone in Philadelphia chromosome positive (Ph+ ) leukemia. The t(9;22)(q34;q11) is a balanced translocation. Der22 involves the BCR (breakpoint cluster region) gene locus with two principal breaks: the M-bcr, encoding for the p210BCR/ABL and the m-bcr, encoding for the 185BCR/ABL fusion proteins, respectively. The constitutively activated BCR/ABL kinase is responsible for the leukemic transformation through an aberrant activation of multiple signaling pathways, such as Stat, Pi3K and Ras/Erk. The der9 encodes for the reciprocal ABL/BCR fusion proteins the p40ABL/BCR, present in 65% of patients with chronic myeloid leukemia (CML) and the p96ABL/BCR, detectable in 100% of patients with Ph+ acute lymphatic leukemia (ALL). ABL/BCRs are oncogenes able to influence the lineage commitment of hematopoietic progenitors. Aim of this study was to further disclose the role of p96ABL/BCR for the pathogenesis of Ph+ ALL. We co-expressed p96ABL/BCRand p185BCR/ ABL from a p2A peptide-linked multi-cistronic retroviral vector, which allows the expression of multiple proteins from a single open reading frame (ORF) to identical levels. The co- expression of p96ABL/BCR enhanced the kinase activity and, as a consequence, the transformation potential of p185BCR/ABL in factor dependent progenitor cells and untransformed fibroblasts. Targeting p96ABL/BCR by RNAi inhibited growth of Ph+ ALL cell lines and primary Ph+ ALL patient-derived long-term cultures (PD-LTCs). Furthermore p96ABL/BCR negatively influenced the response to AKI in these models as shown by an increased response to AKI when p96ABL/BCR was down-regulated. Our in vitro and in vivo stem cell studies on murine fetal liver cells and adult HSCs revealed a functional hierarchy between p96ABL/BCR and p185BCR/ABL. In fact, p96ABL/BCR strongly increased stem cell capacity in replating efficiency and colony forming unit-spleen day 12 (CFU-S12) assays, whereas p185BCR/ABL showed no effect. In contrast co-expression of p96ABL/BCR and p185BCR/ABL increased significantly both serial replating potential and CFU-S12 colony formation as compared to p96ABL/BCR alone. In a syngeneic mouse model co-expression of p96ABL/BCR abolished the capacity of p185BCR/ABL to induce a CML-like disease and led to the induction of ALL. Taken together our here presented data reveal an important role of p96ABL/BCR for the pathogenesis of Ph + ALL. Disclosures No relevant conflicts of interest to declare.

scholarly journals ACUTE LYMPHATIC LEUKEMIA

1912 ◽  
Vol LVIII (13) ◽  
pp. 935 ◽  
Author(s):  
W. H. BODENSTAB
Keyword(s):  
Acute Lymphatic Leukemia ◽  
Lymphatic Leukemia

HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway

2007 ◽  
Vol 39 (7-8) ◽  
pp. 1500-1509 ◽  
Author(s):  
Michael Tsapis ◽  
Michèle Lieb ◽  
Fabio Manzo ◽  
Pattabhiraman Shankaranarayanan ◽  
Raoul Herbrecht ◽  
...  
Keyword(s):  
Hdac Inhibitors ◽  
Leukemia Cells ◽  
Acute Lymphatic Leukemia ◽  
Lymphatic Leukemia ◽  
Lymphatic Leukemia Cells

scholarly journals Immunity to Measles, Mumps and Rubella After Acute Lymphatic Leukemia in Childhood

1999 ◽  
Vol 45 ◽  
pp. 756-756
Author(s):  
A Nilsson ◽  
M Nordin ◽  
F Chiodi ◽  
O Björk
Keyword(s):  
Acute Lymphatic Leukemia ◽  
Lymphatic Leukemia

scholarly journals A Case of Prolonged Thrombocytopenia in Childhood Terminating in Leukemic Reticuloendotheliosis

Blood ◽  
1965 ◽  
Vol 26 (3) ◽  
pp. 360-366 ◽  
Author(s):  
COLIN A. S. GALLOWAY ◽  
ELIZABETH M. INNES
Keyword(s):  
Case History ◽  
Acute Lymphatic Leukemia ◽  
Blood Picture ◽  
Lymphatic Leukemia ◽  
Long Duration ◽  
Persistent Thrombocytopenia

Abstract The case history is reported of a 2-year-old boy who presented with persistent thrombocytopenia, developed a leukoerythroblastic blood picture at 7½ years and died at 9 years of leukemic reticuloendotheliosis. His mother died of acute lymphatic leukemia shortly after the birth, and some of the hereditary aspects of leukemia are discussed. It is suggested that the thrombocytopenia represented a preleukemic state, of unusually long duration, and that this and the leukemic reticuloendotheliosis were different phases of the same basic disorder. The surmise is made that heredity may play a part in the etiology of leukemic reticuloendotheliosis in childhood, a period of life when this disorder is very rare.

Enzootic Bovine Leukemia: C-type Virus in a Cow with Acute Leukemia and in Cattle with Persistent Lymphocytosis from a Dairy Herd.

1975 ◽  
Vol 61 (3) ◽  
pp. 261-270 ◽  
Author(s):  
Luigi Rampichini ◽  
Fernando L. De Castro Portugal ◽  
Maurizio Severini ◽  
Domenico Rutili
Keyword(s):  
Peripheral Blood ◽  
Dairy Herd ◽  
Buffy Coat ◽  
Acute Lymphatic Leukemia ◽  
Persistent Lymphocytosis ◽  
Ultrastructural Studies ◽  
Milk Samples ◽  
Lymphatic Leukemia ◽  
Hematologic Examination ◽  
Microscopy Examination

A case of acute lymphatic leukemia in a 7-month-pregnant Italian Friesian cow, aged about 6 years and belonging to a small dairy herd of 11 cows is described. Hematologic, histopatologic and ultrastructural examinations were performed, the ultrastructural studies were confined to the lymphnodes, thymus and buffy-coat cultures from peripheral blood. The remaining animals were subjected to hematologic examination and electron microscopy examination of buffy-coat cultures from peripheral blood. C-type particles were found in phytohemagglutinin (PHA)-treated and untreated buffy-coat cultures from the leukemic cow and from the animals with persistent lymphocytosis. C-type particles were also found in milk samples from 3 cows with persistent lymphocytosis.

Genetic-Environmental Interaction in Acute Lymphatic Leukemia

2015 ◽  
pp. 161-166 ◽  
Author(s):  
M. Hafez ◽  
H. El-Tahan ◽  
Z. El-Morsi ◽  
Y. Al-Tonbary ◽  
M. El-Ziny ◽  
...  
Keyword(s):  
Acute Lymphatic Leukemia ◽  
Environmental Interaction ◽  
Lymphatic Leukemia
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