Complex Dynamic Structures

Author(s):  
B. Hess ◽  
E. M. Chance ◽  
A. R. Curtis ◽  
A. Boiteux
Physiology ◽  
2006 ◽  
Vol 21 (1) ◽  
pp. 38-47 ◽  
Author(s):  
Barbara Calabrese ◽  
Margaret S. Wilson ◽  
Shelley Halpain

Dendritic spines are small protrusions from neuronal dendrites that form the postsynaptic component of most excitatory synapses in the brain. They play critical roles in synaptic transmission and plasticity. Recent advances in imaging and molecular technologies reveal that spines are complex, dynamic structures that contain a dense array of cytoskeletal, transmembrane, and scaffolding molecules. Several neurological and psychiatric disorders exhibit dendritic spine abnormalities.


2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiaotian Zhang ◽  
Fan Kiat Chan ◽  
Tejaswin Parthasarathy ◽  
Mattia Gazzola

Abstract Natural creatures, from fish and cephalopods to snakes and birds, combine neural control, sensory feedback and compliant mechanics to effectively operate across dynamic, uncertain environments. In order to facilitate the understanding of the biophysical mechanisms at play and to streamline their potential use in engineering applications, we present here a versatile numerical approach to the simulation of musculoskeletal architectures. It relies on the assembly of heterogenous, active and passive Cosserat rods into dynamic structures that model bones, tendons, ligaments, fibers and muscle connectivity. We demonstrate its utility in a range of problems involving biological and soft robotic scenarios across scales and environments: from the engineering of millimeter-long bio-hybrid robots to the synthesis and reconstruction of complex musculoskeletal systems. The versatility of this methodology offers a framework to aid forward and inverse bioengineering designs as well as fundamental discovery in the functioning of living organisms.


Fire ◽  
2019 ◽  
Vol 2 (4) ◽  
pp. 53 ◽  
Author(s):  
Virginia Iglesias ◽  
Boris Vannière ◽  
Isabelle Jouffroy-Bapicot

Socio-ecological systems are complex, dynamic structures driven by cross-scale interactions between climate, disturbance and subsistence strategies. We synthetize paleoecological data to explore the emergence and evolution of anthropogenic landscapes in southwestern Europe and northern Africa. Specifically, we estimate trends in vegetation and fire, and assess how changes in climate and resource exploitation altered ecosystem dynamics over the last 10,000 years. Pollen data reveal that a complex vegetation mosaic resulted from the conversion of forests into areas suitable for crops, especially after 7000 cal yr BP. Cross-scale analysis shows a progressive decoupling of climate and ecosystem trajectories, which displayed an overall south-to-north time-transgressive pattern consistent with models of population expansion. As human impact increased, so did the use of fire, and after 4000 cal yr BP, levels of biomass burning became homogeneous across the region. This region-wide rise in burning suggests that land-management overrode the effects of climate, fuel and topography. Thus, while increasing the returns and predictability of resources, rapidly-growing communities created a new form of frequent and extensive disturbance that led to profound and persistent changes in the landscape, including shrub encroachment, increased erosion and soil impoverishment.


Author(s):  
David A. Agard ◽  
Yasushi Hiraoka ◽  
John W. Sedat

In an effort to understand the complex relationship between structure and biological function within the nucleus, we have embarked on a program to examine the three-dimensional structure and organization of Drosophila melanogaster embryonic chromosomes. Our overall goal is to determine how DNA and proteins are organized into complex and highly dynamic structures (chromosomes) and how these chromosomes are arranged in three dimensional space within the cell nucleus. Futher, we hope to be able to correlate structual data with such fundamental biological properties as stage in the mitotic cell cycle, developmental state and transcription at specific gene loci.Towards this end, we have been developing methodologies for the three-dimensional analysis of non-crystalline biological specimens using optical and electron microscopy. We feel that the combination of these two complementary techniques allows an unprecedented look at the structural organization of cellular components ranging in size from 100A to 100 microns.


2009 ◽  
Author(s):  
Sallie J. Weaver ◽  
Rebecca Lyons ◽  
Eduardo Salas ◽  
David A. Hofmann

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