A Structural Explanation for ERα/ERβ SERM Discrimination

2004 ◽  
pp. 33-45
Author(s):  
G. L. Greene ◽  
A. K. Shiau ◽  
K. W. Nettles
Keyword(s):  
Structural Explanation

Causation, Explanation, and the Metaphysics of Aspect

2018 ◽  
Author(s):  
Bradford Skow
Keyword(s):  
Background Condition ◽  
Structural Explanation ◽  
Levels Of Explanation ◽  
Lexical Aspect ◽  
The Third ◽  
Main Verb ◽  
The Difference ◽  
In Virtue Of

This book aims to answer the following questions: what is the difference between a cause and a background condition? What is it to manifest a disposition? Can dispositions be extrinsic? What is the most basic kind of causation? And, what might a structural explanation be? Each chapter takes up a subset of these questions; the chapters are written to be readable independently. The answers defended rely on three ideas. Two of those ideas use a distinction from the study of lexical aspect, namely the distinction between stative verbs and non-stative verbs. The first idea is that events go with non-stative verbs, in the sense that “If S, then an event occurred in virtue of the fact that S” is true when the main verb in the clause going in for “S” is non-stative. The second is that acting, doing something, goes with non-stative verbs, in the sense that “In Ving X did something” is true iff V is a non-stative verb. The third idea is about levels of explanation: “(A because B) because C” does not entail “A because C.”

scholarly journals Crystallization and X-ray diffraction data analysis of human deoxyhaemoglobin A0 fully stripped of any anions

1999 ◽  
Vol 55 (11) ◽  
pp. 1914-1916 ◽  
Author(s):  
F. A. V. Seixas ◽  
W. F. de Azevedo ◽  
M. F. Colombo
Keyword(s):  
Diffraction Data ◽  
Oxygen Affinity ◽  
X Ray Diffraction ◽  
Structural Explanation ◽  
Human Haemoglobin ◽  
X Ray ◽  
High Resolution Structure ◽  
Allosteric Properties

In this work, initial crystallographic studies of human haemoglobin (Hb) crystallized in isoionic and oxygen-free PEG solution are presented. Under these conditions, functional measurements of the O2-linked binding of water molecules and release of protons have evidenced that Hb assumes an unforeseen new allosteric conformation. The determination of the high-resolution structure of the crystal of human deoxy-Hb fully stripped of anions may provide a structural explanation for the role of anions in the allosteric properties of Hb and, particularly, for the influence of chloride on the Bohr effect, the mechanism by which Hb oxygen affinity is regulated by pH. X-ray diffraction data were collected to 1.87 Å resolution using a synchrotron-radiation source. Crystals belong to the space group P21212 and preliminary analysis revealed the presence of one tetramer in the asymmetric unit. The structure is currently being refined using maximum-likelihood protocols.

scholarly journals Structural explanation of poor prognosis of amyotrophic lateral sclerosis in the non-demented state

2016 ◽  
Vol 24 (1) ◽  
pp. 122-129 ◽  
Author(s):  
H.-J. Kim ◽  
S.-I. Oh ◽  
M. de Leon ◽  
X. Wang ◽  
K.-W. Oh ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Poor Prognosis ◽  
Structural Explanation ◽  
Lateral Sclerosis

scholarly journals Premature Ventricular Contractions During the Recovery Phase of Exercise Are Only Associated with Increased Cardiovascular Mortality when Present Together with Echocardiographic Abnormalities

2021 ◽  
Author(s):  
Thomas Lindow ◽  
Magnus Ekstrom ◽  
Lars Brudin ◽  
Kristofer Hedman ◽  
Martin Ugander
Keyword(s):  
Cardiovascular Mortality ◽  
Cox Regression ◽  
Stress Test ◽  
Exercise Stress Test ◽  
Recovery Phase ◽  
Left Ventricular ◽  
Exercise Stress ◽  
Structural Explanation ◽  
Premature Ventricular Contractions ◽  
Increased Risk

Background: Premature ventricular contractions (PVCs) during the recovery of exercise stress testing are associated with increased cardiovascular mortality, but the cause remains unknown. We aimed to evaluate the association of PVCs during recovery with abnormalities on echocardiography, and to evaluate their combined prognostic performance. Methods: Echocardiographic abnormalities (reduced left ventricular (LV) ejection fraction, valvular heart disease, LV dilatation, LV hypertrophy, or increased filling pressures) and the presence of PVCs during recovery (≥1/min) were identified among patients having undergone resting echocardiography within median [interquartile range] 0 [0-2] days of an exercise stress test. The association between such changes and cardiovascular mortality was analyzed using Cox regression adjusted for age, sex, clinical and exercise variables. Results: Among included patients (n=3,106, 219 events, 7.9 [5.4-11.1] years follow-up), PVCs during recovery was found in 1,327 (43%) patients, among which prevalence of echocardiographic abnormalities was increased (58% vs. 43%, p<0.001). Overall, PVCs during recovery was associated with increased cardiovascular mortality (adjusted hazard ratio (HR) [95% confidence interval] 1.6 [1.2-2.1], p<0.001). When combined with echocardiographic abnormalities, PVCs during recovery was only associated with increased risk when such were present (adjusted HR 3.3 [2.0-5.4], p<0.001), and not when absent (adjusted HR 1.4 [0.7-2.6], p=0.26), in reference to those with neither. Conclusion: PVCs during recovery was associated with increased prevalence of echocardiographic abnormalities. Increased risk of cardiovascular mortality was observed only for subjects with PVCs if concomitant echocardiographic abnormalities were present. This provides a structural explanation for the increased long-term cardiovascular risk among patients with PVCs during recovery.

A Structural Explanation for Sino-US-Venezuelan Relations

2017 ◽  
Author(s):  
Anthony Petros Spanakos
Keyword(s):  
Foreign Policy ◽  
South America ◽  
Global Governance ◽  
Regional Governance ◽  
Chinese Foreign Policy ◽  
Us Foreign Policy ◽  
Governance System ◽  
Structural Explanation ◽  
The Us ◽  
The Way

US-Venezuelan relations display both confrontation and cooperation. Chinese relations with Venezuela are a most likely case for rebellion against the global governance system over which the US presides. This chapter makes a structuralist argument, arguing that the way that the three countries are positioned within global and regional governance structures conditions the underlying character of their relations with each other. Simply put, the US, China, and Venezuela have very different interests and capabilities and their structural positions in South America explain why the increased Chinese presence in Venezuela is neither a threat to the US nor does it substantially aid Venezuelan intentions toward multi-polarizing the region or world. To make this argument, the chapter assumes that US foreign policy toward Venezuela is informed by its position as regional hegemon, Chinese foreign policy toward Venezuela is informed by its position as an extra-regional commercial state, and Venezuelan foreign policy toward both is informed by its position as a petrostate.

Comparison of amounts of collagen and elastin in pleura and parenchyma of dog lung

1984 ◽  
Vol 56 (5) ◽  
pp. 1383-1388 ◽  
Author(s):  
E. H. Oldmixon ◽  
F. G. Hoppin
Keyword(s):  
Collagen Fibrils ◽  
Visceral Pleura ◽  
Structural Explanation ◽  
Structural Result ◽  
Substantial Role ◽  
Frictional Forces ◽  
Volume Characteristics ◽  
Alveolar Septa ◽  
Alveolar Parenchyma

Pressure-volume characteristics of the lung have been thought to be due primarily to the properties of the network of alveolar septa. However, Hajji et al. (J. Appl. Physiol.: Respirat . Environ. Exercise Physiol. 47: 175–181, 1979) attributed a substantial role to the visceral pleura. Seeking a structural explanation for this result, we compared the relative amounts of collagen fibrils and elastin fibers in the visceral pleura and alveolar parenchyma using stereological measurements in five canine lobes. We found about one-fifth as much collagen and one-tenth as much elastin in the pleura as in the alveolar parenchyma. This structural result confirms the functional conclusions of Hajji et al. We argue that such a substantial structure is not needed for protection against overinflation but may have to do with stabilization of lobe shape or handling of frictional forces.

scholarly journals Understanding the Lingual Frenulum: Histological Structure, Tissue Composition, and Implications for Tongue Tie Surgery

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Nikki Mills ◽  
Donna T. Geddes ◽  
Satya Amirapu ◽  
S. Ali Mirjalili
Keyword(s):  
Individual Variability ◽  
Histological Structure ◽  
Tissue Composition ◽  
En Bloc ◽  
Structural Explanation ◽  
Fresh Tissue ◽  
Floor Of Mouth ◽  
Variable Extent ◽  
The Individual ◽  
Picrosirius Red

Lingual frenotomy has become an increasingly common surgical procedure, performed for a broad range of indications from birth through adulthood. This study utilizes histology to define the structure and tissue composition of the lingual frenulum and floor of mouth (FOM) fascia. En bloc specimens of anterior tongue, lingual frenulum, and FOM tissues were harvested from ten embalmed adult cadavers. An additional three fresh tissue cadaveric specimens were frozen with the tongue supported in an elevated position, to enable harvesting and paraffin embedding of the elevated lingual frenulum as a discrete specimen. All 13 specimens were prepared as ten-micron coronal sections using stains to determine the general morphology of the lingual frenulum, its relationship to neighbouring structures (Mason’s Trichrome), presence of elastin fibers (Verhoeff-van Gieson), and collagen typing (Picrosirius Red). Our results have shown a submucosal layer of fascia spanning horizontally across the FOM was present in all specimens, with variability in fascial thickness and histologic composition. This FOM fascia suspends the sublingual glands, vessels, and genioglossus from its deep surface. The elevated lingual frenulum is formed by a central fold of this FOM fascia together with the overlying oral mucosa with variability in fascial thickness and composition. With tongue elevation, the fascia mobilizes to a variable extent into the fold forming the frenulum, providing a structural explanation for the individual variability in lingual frenulum morphology seen in clinical practice.

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