Helicobacter Pylori Vacuolating Cytotoxin

2000 ◽  
pp. 489-507
Author(s):  
W. Fischer ◽  
R. Haas
Keyword(s):  
Helicobacter Pylori ◽  
Vacuolating Cytotoxin

Helicobacter pylori vacuolating cytotoxin (VacA) inhibits tubulovesicle fusion-possible mechanism for the inhibition of acid secretion in isolated gastric glands

2001 ◽  
Vol 120 (5) ◽  
pp. A652-A652
Author(s):  
S KARVAR ◽  
J DUMAN ◽  
X YAO ◽  
R ZHOU ◽  
T COVER ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Acid Secretion ◽  
Gastric Glands ◽  
Vacuolating Cytotoxin ◽  
Isolated Gastric Glands

scholarly journals Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.

1994 ◽  
Vol 269 (14) ◽  
pp. 10566-10573 ◽  
Author(s):  
T.L. Cover ◽  
M.K. Tummuru ◽  
P. Cao ◽  
S.A. Thompson ◽  
M.J. Blaser
Keyword(s):  
Helicobacter Pylori ◽  
Vacuolating Cytotoxin ◽  
Genetic Sequences

scholarly journals Prevalence of Vacuolating Cytotoxin Production and Distribution of Distinct vacA Alleles in Helicobacter pylori from China

1998 ◽  
Vol 178 (1) ◽  
pp. 220-226 ◽  
Author(s):  
Z.-J. Pan ◽  
D. E. Berg ◽  
R. W. M. van der Hulst ◽  
W.-W. Su ◽  
A. Raudonikiene ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Vacuolating Cytotoxin ◽  
Production And Distribution

scholarly journals Effect of Helicobacter pylori on Polymorphonuclear Leukocyte Migration across Polarized T84 Epithelial Cell Monolayers: Role of Vacuolating Toxin VacA and cagPathogenicity Island

2000 ◽  
Vol 68 (9) ◽  
pp. 5225-5233 ◽  
Author(s):  
Véronique Hofman ◽  
Vittorio Ricci ◽  
Antoine Galmiche ◽  
Patrick Brest ◽  
Patrick Auberger ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Polymorphonuclear Leukocyte ◽  
Broth Culture ◽  
Intestinal Cell ◽  
T84 Cells ◽  
Vacuolating Cytotoxin ◽  
Intestinal Cell Line ◽  
H Pylori

ABSTRACT Helicobacter pylori infection can induce polymorphonuclear leukocyte (PMNL) infiltration of the gastric mucosa, which characterizes acute chronic gastritis. The mechanisms underlying this process are poorly documented. The lack of an in vitro model has considerably impaired the study of transepithelial migration of PMNL induced by H. pylori. In the present work, we used confluent polarized monolayers of the human intestinal cell line T84 grown on permeable filters to analyze the epithelial PMNL response induced by broth culture filtrates (BCFs) and bacterial suspensions from different strains of H. pylori. We have evaluated the role of the vacuolating cytotoxin VacA and of the cagpathogenicity island (PAI) of H. pylori in PMNL migration via their effects on T84 epithelial cells. We noted no difference in the rates of PMNL transepithelial migration after epithelial preincubation with bacterial suspensions or with BCFs of VacA-negative or VacA-positive H. pylori strains. In contrast, PMNL transepithelial migration was induced after incubation of the T84 cells with cag PAI-positive and cagE-positiveH. pylori strains. Finally, PMNL migration was correlated with a basolateral secretion of interleukin-8 by T84 cells, thus creating a subepithelial chemotactic gradient for PMNL. These data provide evidence that the vacuolating cytotoxin VacA is not involved in PMNL transepithelial migration and that the cag PAI, with a pivotal role for the cagE gene, provokes a transcellular signal across T84 monolayers, inducing a subepithelial PMNL response.

scholarly journals Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori.

1994 ◽  
Vol 62 (6) ◽  
pp. 2609-2613 ◽  
Author(s):  
M K Tummuru ◽  
T L Cover ◽  
M J Blaser
Keyword(s):  
Helicobacter Pylori ◽  
Caga Gene ◽  
Vacuolating Cytotoxin

scholarly journals Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer

2020 ◽  
Vol 8 (11) ◽  
pp. 1698
Author(s):  
Meira Epplein ◽  
Loïc Le Marchand ◽  
Timothy L. Cover ◽  
Mingyang Song ◽  
William J. Blot ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Helicobacter Pylori ◽  
Regression Models ◽  
Conditional Logistic Regression ◽  
Serum Antibody ◽  
Antibody Responses ◽  
Vacuolating Cytotoxin ◽  
Logistic Regression Models ◽  
Streptococcus Gallolyticus ◽  
Increased Risk

Previously, we found that risk of colorectal cancer (CRC) is increased in individuals with serum antibody response to both Helicobacter pylori (HP) Vacuolating Cytotoxin (VacA) toxin or Streptococcus gallolyticus (SGG) pilus protein Gallo2178. In the present analysis, we tested the hypothesis that combined seropositivity to both antigens is a better indicator of CRC risk than seropositivity to single antigens. We used multiplex serologic assays to analyze pre-diagnostic serum for antibody responses from 4063 incident CRC cases and 4063 matched controls from 10 US cohorts. To examine whether combined SGG Gallo2178 and HP VacA sero-status was associated with CRC risk, we used conditional logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Compared to dual sero-negative individuals, there was no increased risk for individuals sero-positive to SGG Gallo2178 only (OR: 0.93; 95% CI: 0.66–1.31) or to HP VacA only (OR: 1.08; 95% CI: 0.98–1.19). However, dual sero-positive individuals had a >50% increased odds of developing CRC (OR: 1.54; 95% CI: 1.16–2.04), suggesting an interaction between antibody responses to these two pathogens and CRC risk (pinteraction = 0.06). In conclusion, this study suggests that dual sero-positivity to HP VacA and SGG Gallo2178 is an indicator of increased risk of CRC.

Helicobacter pylori Vacuolating Cytotoxin, VacA, Is Responsible for Gastric Ulceration

2004 ◽  
Vol 136 (6) ◽  
pp. 741-746 ◽  
Author(s):  
A. Wada
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulceration ◽  
Vacuolating Cytotoxin

Helicobacter pylori vacuolating cytotoxin induces apoptosis via activation of endoplasmic reticulum stress in dendritic cells

2014 ◽  
Vol 30 (1) ◽  
pp. 99-108 ◽  
Author(s):  
Jung Mogg Kim ◽  
Joo Sung Kim ◽  
Nayoung Kim ◽  
Su Hyuk Ko ◽  
Jong Ik Jeon ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Helicobacter Pylori ◽  
Dendritic Cells ◽  
Endoplasmic Reticulum Stress ◽  
Vacuolating Cytotoxin
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