Stratum Corneum Lipid Liposomes: Drug Delivery Systems and Skin Models

2016 ◽  
pp. 111-119
Author(s):  
Gamal M. El Maghraby
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stratum Corneum Lipid ◽  
Stratum Corneum Lipid Liposomes ◽  
Lipid Liposomes

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

scholarly journals Effects of Ca2+ ion and Limonene on the Fusion of Stratum Corneum Lipid Liposomes.

MEMBRANE ◽  
2000 ◽  
Vol 25 (5) ◽  
pp. 257-263 ◽  
Author(s):  
Yasushi Sumida ◽  
Koichiro Miyajima
Keyword(s):  
Stratum Corneum ◽  
Stratum Corneum Lipid ◽  
Stratum Corneum Lipid Liposomes ◽  
Lipid Liposomes

Microneedle-mediated transdermal nanodelivery systems: a review

2021 ◽  
Author(s):  
Shuyao Ruan ◽  
Yong-Tai Zhang ◽  
Nian-Ping Feng
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Barrier Function ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery Systems

The greatest limitation in the development of transdermal drug delivery systems is that only a few drugs can permeate the skin due to the barrier function of the stratum corneum....

A general approach on the surfactants use and their properties in drug delivery systems

2021 ◽  
Vol 27 ◽  
Author(s):  
Mysrayn Yargo de Freitas Araújo Reis ◽  
Renaly Ivyna de Araújo Rêgo ◽  
Beatriz Patrício Rocha ◽  
Gabryella Garcia Guedes ◽  
Ízola Morais de Medeiros Ramalho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Epithelial Cells ◽  
Stratum Corneum ◽  
Chain Length ◽  
Formation Process ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Dissolution Profile ◽  
Amphiphilic Molecules

: Surfactants are amphiphilic molecules of great interest in the pharmaceutical field due to their use in combination with other adjuvants to solubilize poor soluble drugs, improve their dissolution profile, promote permeation, increase drug delivery systems stabilization, among other characteristics. Literature shows that surfactants are included in several pharmaceutical forms composition: tablets, solid dispersions, emulsions, microemulsions, nanoemulsions, liposomes, and niosomes. This review aims to elucidate the different classes of surfactants based on their charges (cationic, anionic, nonionic, zwitterionic, and dimeric), the micelles formation process, and how surfactants molecules geometry can affect this phenomenon. Moreover, current studies regarding the benefits of surfactants in the development of formulations are presented. Finally, a discussion on how charges and chain length of surfactants can interact with the stratum corneum epithelial cells leading to increased permeation or skin irritability is reported.

Fluorescent Probe Studies of the Interactions of 1-Alkyl-2-Pyrrolidones with Stratum Corneum Lipid Liposomes

1996 ◽  
Vol 85 (5) ◽  
pp. 511-517 ◽  
Author(s):  
Kunio Yoneto ◽  
S. Kevin LI ◽  
William I. Higuchi ◽  
Wim Jiskoot ◽  
James N. Herron
Keyword(s):  
Stratum Corneum ◽  
Fluorescent Probe ◽  
Stratum Corneum Lipid ◽  
Stratum Corneum Lipid Liposomes ◽  
Lipid Liposomes
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