A general approach on the surfactants use and their properties in drug delivery systems

2021 ◽  
Vol 27 ◽  
Author(s):  
Mysrayn Yargo de Freitas Araújo Reis ◽  
Renaly Ivyna de Araújo Rêgo ◽  
Beatriz Patrício Rocha ◽  
Gabryella Garcia Guedes ◽  
Ízola Morais de Medeiros Ramalho ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Epithelial Cells ◽  
Stratum Corneum ◽  
Chain Length ◽  
Formation Process ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Dissolution Profile ◽  
Amphiphilic Molecules

: Surfactants are amphiphilic molecules of great interest in the pharmaceutical field due to their use in combination with other adjuvants to solubilize poor soluble drugs, improve their dissolution profile, promote permeation, increase drug delivery systems stabilization, among other characteristics. Literature shows that surfactants are included in several pharmaceutical forms composition: tablets, solid dispersions, emulsions, microemulsions, nanoemulsions, liposomes, and niosomes. This review aims to elucidate the different classes of surfactants based on their charges (cationic, anionic, nonionic, zwitterionic, and dimeric), the micelles formation process, and how surfactants molecules geometry can affect this phenomenon. Moreover, current studies regarding the benefits of surfactants in the development of formulations are presented. Finally, a discussion on how charges and chain length of surfactants can interact with the stratum corneum epithelial cells leading to increased permeation or skin irritability is reported.

A Comparative Study of Selected Drug Delivery Systems: Key Emphasis on Cocrystallization

2021 ◽  
Vol 11 ◽  
Author(s):  
Braham Dutt ◽  
Manjusha Choudhary ◽  
Vikas Budhwar
Keyword(s):  
Drug Delivery ◽  
Solid Dispersion ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Stoichiometric Ratio ◽  
Dissolution Profile ◽  
Advantages And Disadvantages ◽  
Low Solubility ◽  
Delivery Techniques

Background: The low solubility of an active pharmaceutical ingredient particularly biopharmaceutics classification system (BCS) Class II drugs leads to lower dissolution profile which in result cause reduction in overall bioavailability of drugs. Numerous approaches like nanotechnology, solid dispersion technique, micronization techniques etc were aimed by scientists in the past to resolve this issue, but still not enough to get the desired outcomes. Objective: Key focus of this review is study of advantages and disadvantages of cocrystallization, nanotechnology and solid dispersions drug delivery techniques and benefits of using cocrystallization techniques over above-mentioned techniques. Methods: Various parameters including pharmaceutical, pharmacological and toxicological effects related to these mentioned drug delivery systems have been compared. There advantages and disadvantages have been elaborated. Result: For drug delivery purpose, cocrystallization process has numerous advantages over nanotechnology and solid dispersions drug delivery techniques discussed in the text. Cocrystallization is newer technique that can modify the physicochemical and pharmaceutical properties of active pharmaceutical ingredients (API) are having issues like low solubility, low stability or sensitivity toward environmental hazards like temperature, moisture or photostability issues. During cocrystallization, drug and coformer interact with each other non-covalently in a fixed stoichiometric ratio. The availability of large amount of coformers make this technique to be favourable for the researchers in designing cocrystals of newer and older API’s. Conclusion: Although, solid dispersions and nanotechnology techniques are being utilised to a larger extent but still there are some drawbacks of these techniques like stability, toxicological factors and protection from environmental factors needs to be considered, while cocrystallization process drastically modifies the various pharmaceutical parameters without altering the pharmacological properties of API’s. Here in this review we performed a comparative analysis between nanotechnology, solid dispersion and cocrystallization techniques along with importance of cocrystallization in modification of drug profile and various applications of it in pharmaceutical and allied industry.

scholarly journals Enhancement strategies for transdermal drug delivery systems: current trends and applications

2021 ◽  
Author(s):  
Delly Ramadon ◽  
Maeliosa T. C. McCrudden ◽  
Aaron J. Courtenay ◽  
Ryan F. Donnelly
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Global Market ◽  
Therapeutic Drug ◽  
Current Trends ◽  
Transdermal Drug Delivery Systems

AbstractTransdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

Microneedle-mediated transdermal nanodelivery systems: a review

2021 ◽  
Author(s):  
Shuyao Ruan ◽  
Yong-Tai Zhang ◽  
Nian-Ping Feng
Keyword(s):  
Drug Delivery ◽  
Stratum Corneum ◽  
Barrier Function ◽  
Transdermal Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Drug Delivery Systems

The greatest limitation in the development of transdermal drug delivery systems is that only a few drugs can permeate the skin due to the barrier function of the stratum corneum....

scholarly journals Nanotechnologies for Curcumin: An Ancient Puzzler Meets Modern Solutions

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Shengpeng Wang ◽  
Miao Tan ◽  
Zhangfeng Zhong ◽  
Meiwan Chen ◽  
Yitao Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Skin Diseases ◽  
Curcuma Longa ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Protective Agent ◽  
Natural Polyphenol ◽  
Preclinical Trials ◽  
High Doses

Curcumin, a low-molecular-weight natural polyphenol mainly found in the plantCurcuma longa(turmeric), is widely used as a food colorant and as a potential protective agent against several chronic diseases including cancer, HIV-infection, neurological, cardiovascular, and skin diseases. Moreover, evidences from long-term use process and preclinical trials have demonstrated low toxicity of curcumin, even at relatively high doses. However, it has been well known that the application of curcumin was limited owing to its water insolubility, instability, and poor bioavailability. For decades, many attempts have been made to compensate for these disadvantages, with the development of improved delivery platforms as the feasible approaches. The past ten years witnessed the encouraging progress in the use of nanoscale drug delivery systems on curcumin such as loading curcumin into liposomes or nanoparticles, forming self-microemulsifying drug delivery systems (SMEDDS), cyclodextrin inclusions, and solid dispersions, as well as the latest reported technologies such as nadodisks and nanotubes. This paper summarizes the recent works on the design and development of nanoscale delivery systems of curcumin, with the goal of harnessing the true difficulties of this multifunctional agent in the clinical arena.

scholarly journals Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Samatha Akula ◽  
Aravind Kumar Gurram ◽  
Srinivas Reddy Devireddy
Keyword(s):  
Drug Delivery ◽  
Oral Bioavailability ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Oral Route ◽  
Delivery Systems ◽  
Water Soluble ◽  
Lymphatic Transport ◽  
Water Soluble Drugs ◽  
Solubilized Form

Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs with minimum dose. Although many formulation approaches like solid dispersions, complexation, pH modification, and cocrystals exist, lipid based delivery systems finding increased appliance with the apparent increase in absorption of drug. Among lipid based formulations, self-microemulsifying formulations (droplet size < 100 nm) are evident to improve the oral bioavailability of hydrophobic drugs primarily due to their efficiency in facilitating solubilization and in presenting the hydrophobic drug in solubilized form whereby dissolution process can be circumvented. Various components that are used to formulate these dosage forms like surfactants and lipids contribute to the overall improvement in oral bioavailability via promoting the lymphatic transport; thereby hepatic first pass metabolism can be surmounted. The present paper gives exhaustive information on the formulation design and characterization of SMEDDS along with the probable mechanisms by which the bioavailability can be improved with SMEDDS.

scholarly journals Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1968
Author(s):  
Mina Zare ◽  
Karolina Dziemidowicz ◽  
Gareth R. Williams ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Strong Electric Field ◽  
Solid Dispersions ◽  
Electrospun Nanofibers ◽  
Amorphous Solid ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
Biological And Medical Applications

Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.

scholarly journals Linagliptin loaded Solid-SMEEDS for enhanced solubility and dissolution: Formulation development and optimization by D-optimal design

2019 ◽  
Vol 9 (2) ◽  
pp. 47-56
Author(s):  
Madhubhai M Patel ◽  
Rahulkumar J Patel
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Transmission Electron Microscopy ◽  
Optimal Design ◽  
Zeta Potential ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Dissolution Profile ◽  
Transmission Electron

The aim of the present investigation was to formulate and evaluate solid self-micro emulsifying drug-delivery systems (S-SMEDDS) to improve solubility and dissolution profile of Linagliptin. Solubility of Linagliptin in different oils, surfactants and co-surfactants was assessed and optimizations of pseudo-ternary plots were also carried out for preparation of liquid SMEDDS. D-optimal design mixture was used in the optimization of Linagliptin loaded liquid SMEEDS. The optimized SMEEDS were characterized for globule size, zeta potential, dilution stability, transmittance, pH and in-vitro release profile. The morphology of the Linagliptin SMEEDS was observed by Transmission Electron Microscopy (TEM). Among the different silicates, Nusillin US2 was used as the solid carrier/absorbent to formulate S-SMEEDS of Linagliptin. Improved in-vitro dissolution profile of optimized formulation was observed, resulting in multifold improvement in the absorption profile of Linagliptin as compared with pure drug. In a nutshell, this optimized S-SMEDD formulation holds great promise for enhancement of its physiochemical and biological attributes. Keywords: Linagliptin, Solid Self-micro Emulsifying Drug Delivery Systems, D-optimal design, Zeta-potential, Transmission Electron Microscopy

Investigation of novel supersaturating drug delivery systems of chlorthalidone: The use of polymer-surfactant complex as an effective carrier in solid dispersions

2018 ◽  
Vol 111 ◽  
pp. 142-152 ◽  
Author(s):  
Maria Terezinha França ◽  
Rafael Nicolay Pereira ◽  
Manoela Klüppel Riekes ◽  
Juliana Munari Oliveira Pinto ◽  
Hellen Karine Stulzer
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Solid Dispersions ◽  
Delivery Systems ◽  
Surfactant Complex ◽  
Polymer Surfactant ◽  
Effective Carrier
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