Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization

1999 ◽  
pp. 125-136 ◽  
Author(s):  
O. Labudova ◽  
E. Kitzmueller ◽  
H. Rink ◽  
N. Cairns ◽  
G. Lubec
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Subtractive Hybridization ◽  
Down Syndrome Brain

scholarly journals Gene expression profiling in the adult Down syndrome brain

Genomics ◽  
2007 ◽  
Vol 90 (6) ◽  
pp. 647-660 ◽  
Author(s):  
H.E. Lockstone ◽  
L.W. Harris ◽  
J.E. Swatton ◽  
M.T. Wayland ◽  
A.J. Holland ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Down Syndrome Brain

Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain

Genomics ◽  
2003 ◽  
Vol 81 (5) ◽  
pp. 457-467 ◽  
Author(s):  
Rong Mao ◽  
Carol L. Zielke ◽  
H. Ronald Zielke ◽  
Jonathan Pevsner
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Chromosome 21 ◽  
Down Syndrome Brain

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models

2021 ◽  
Vol 535 ◽  
pp. 87-92
Author(s):  
Ryohei Shimizu ◽  
Keiichi Ishihara ◽  
Eri Kawashita ◽  
Haruhiko Sago ◽  
Kazuhiro Yamakawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Down Syndrome ◽  
Mouse Models ◽  
Embryonic Brain ◽  
Adult Hippocampus

Manifold decrease of sialic acid synthase in fetal Down syndrome brain

Amino Acids ◽  
2006 ◽  
Vol 32 (1) ◽  
pp. 141-144 ◽  
Author(s):  
T. Gulesserian ◽  
E. Engidawork ◽  
M. Fountoulakis ◽  
G. Lubec
Keyword(s):  
Down Syndrome ◽  
Sialic Acid ◽  
Down Syndrome Brain

scholarly journals Persistent Changes in Gene Expression Induced by Estrogen and Progesterone in the Rat Mammary Gland

2001 ◽  
Vol 15 (11) ◽  
pp. 1993-2009 ◽  
Author(s):  
Melanie R. Ginger ◽  
Maria F. Gonzalez-Rimbau ◽  
Jason P. Gay ◽  
Jeffrey M. Rosen
Keyword(s):  
Gene Expression ◽  
Mammary Gland ◽  
Cell Fate ◽  
Noncoding Rna ◽  
Previous Treatment ◽  
Hormone Treatment ◽  
Subtractive Hybridization ◽  
Epidemiological Studies ◽  
Altered Expression ◽  
Hormonal Milieu

Abstract Epidemiological studies have consistently shown that an early full-term pregnancy is protective against breast cancer. We hypothesize that the hormonal milieu that is present during pregnancy results in persistent changes in the pattern of gene expression in the mammary gland, leading to permanent changes in cell fate that determine the subsequent proliferative response of the gland. To investigate this hypothesis, we have used suppression subtractive hybridization to identify genes that are persistently up-regulated in the glands of E- and progesterone (P)-treated Wistar-Furth rats 28 d after steroid hormone treatment compared with age-matched virgins. Using this approach, a number of genes displaying persistent altered expression in response to previous treatment with E and P were identified. Two markers have been characterized in greater detail: RbAp46 and a novel gene that specifies a noncoding RNA (designated G.B7). Both were persistently up-regulated in the lobules of the regressed gland and required previous treatment with both E and P for maximal persistent expression. RbAp46 has been implicated in a number of complexes involving chromatin remodeling, suggesting a mechanism whereby epigenetic factors responsible for persistent changes in gene expression may be related to the determination of cell fate. These results provide the first support at the molecular level for the hypothesis that hormone-induced persistent changes in gene expression are present in the involuted mammary gland.

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