In vivo Measurement of Intra- and Extracellular Space of Brain Tissue by Electrical Impedance Method

1990 ◽  
pp. 22-24
Author(s):  
Sadao Suga ◽  
S. Mitani ◽  
Y. Shimamoto ◽  
T. Kawase ◽  
S. Toya ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Extracellular Space ◽  
Electrical Impedance ◽  
Impedance Method ◽  
In Vivo Measurement

scholarly journals In vivo Measurement of Regional Brain and Tumor pH Using [14C]Dimethyloxazolidinedione and Quantitative Autoradiography. II: Characterization of the Extracellular Fluid Compartment Using pH-Sensitive Microelectrodes and [14C]Sucrose

1986 ◽  
Vol 6 (4) ◽  
pp. 435-440 ◽  
Author(s):  
James B. Arnold ◽  
Richard P. Kraig ◽  
David A. Rottenberg
Keyword(s):  
Brain Tissue ◽  
Extracellular Space ◽  
Extracellular Fluid ◽  
Water Volume ◽  
Normal Brain ◽  
In Vivo Measurement ◽  
Tumor Ph ◽  
Fluid Compartment ◽  
Arterial Ph

We measured the extracellular (interstitial) pH (pHe) of RG-2 rat gliomas using H+-sensitive microelectrodes and estimated the volume of tumor extracellular space based on the tissue-plasma ratio of [14C]sucrose. The average RG-2 pHe was 7.63 ± 0.15 (mean ± SD, n = 6), whereas the average pHe of contralateral brain tissue was 7.34 ± 0.10 (n = 3) and arterial pH was 7.36 ± 0.02. RG-2 extracellular space water volume was estimated to be 0.3 ml water/g tissue. In separate experiments in normal, nontumored rats, intracellular pH (pHi) was calculated for nine gray and white matter regions based on measurements of tissue and plasma [14C]dimethyloxazolidinedione concentration. pHi values ranged from 6.80 to 6.94, and no consistent gray–white differences were observed. Our data suggest that tumor pHi is not more acidic than that of normal brain tissue and that the observed alkalinity of primary brain tumors is due to the presence of a large alkaline extracellular space.

scholarly journals Prompt Gamma Ray Spectrometry for In Vivo Measurement of Boron-10 Concentration in Rabbit Brain Tissue

1995 ◽  
Vol 35 (12) ◽  
pp. 855-860 ◽  
Author(s):  
Kanji MUKAI ◽  
Yoshinobu NAKAGAWA ◽  
Keizo MATSUMOTO
Keyword(s):  
Brain Tissue ◽  
Gamma Ray ◽  
Rabbit Brain ◽  
Gamma Ray Spectrometry ◽  
Prompt Gamma ◽  
In Vivo Measurement

In vivo measurement of regional brain tissue pH using positron emission tomography

1984 ◽  
Vol 15 (S1) ◽  
pp. 98-102 ◽  
Author(s):  
D. A. Rottenberg ◽  
J. Z. Ginos ◽  
K. J. Kearfott ◽  
L. Junck ◽  
D. D. Bigner
Keyword(s):  
Positron Emission Tomography ◽  
Brain Tissue ◽  
Emission Tomography ◽  
Tissue Ph ◽  
In Vivo Measurement ◽  
Regional Brain ◽  
Positron Emission

scholarly journals Determination of organ volume using Focused Impedance Method (FIM): a simulation approach

2015 ◽  
Vol 7 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Sayed Parvez Ahmed ◽  
M Abdul Kadir ◽  
Rubina Rahman ◽  
Golam Dastegir Al-Quaderi ◽  
K Siddique-e Rabbani
Keyword(s):  
Human Body ◽  
Medical Physics ◽  
Simulation Software ◽  
Impedance Method ◽  
Surface Electrodes ◽  
In Vivo Measurement ◽  
Enhanced Sensitivity ◽  
Organ Volume

A noninvasive and radiation free technique for in-vivo measurement of the volume of organs or fluids in the human body is necessary for many clinical applications. Focused Impedance Method (FIM) is a novel technique of electrical impedance measurements which has enhanced sensitivity in a localized region. FIM can sense the change in transfer impedance of an organ within a reasonable depth of the human body using surface electrodes, minimizing contributions from its neighbouring regions. This of course assumes that the impedance properties of the embedded object are different from that of its surrounding tissues. This paper presents a new method for the determination of the volume of an organ within body using dual electrode separations of a concentric 4-electrode FIM configuration. In order to develop this formalism simulated FIM measurements using surface electrodes on a cubic volume conductor with embedded spherical objects were performed using a Finite Element (FE) based simulation software, COMSOL Multiphysics®. For the present methodology, the conductivity of the object with respect to its surroundings and its depth need to be known. The former is obtainable through some primary invasive or in vivo measurements while the latter may be approximated using anatomy. Experimental results on a phantom made up of a cubic tank filled with saline showed that the proposed method can be used to determine the volume of embedded objects to an accuracy of about 5% which is adequate for most physiological measurements. The technique may also find use in geology, oceanography and industry.Bangladesh Journal of Medical Physics Vol.7 No.1 2014 24-33

In vivo measurement of the electrical impedance of cell membranes of tobacco cultured cells with a multifunctional microelectrode system

1998 ◽  
Vol 45 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Hidekazu Sotoyama ◽  
Mikako Saito ◽  
Ki-Bong Oh ◽  
Yasuyuki Nemoto ◽  
Hideaki Matsuoka
Keyword(s):  
Electrical Impedance ◽  
Cell Membranes ◽  
Cultured Cells ◽  
In Vivo Measurement

scholarly journals Microsensors for in vivo Measurement of Glutamate in Brain Tissue

Sensors ◽  
2008 ◽  
Vol 8 (11) ◽  
pp. 6860-6884 ◽  
Author(s):  
Si Qin ◽  
Miranda Van der Zeyden ◽  
Weite Oldenziel ◽  
Thomas Cremers ◽  
Ben Westerink
Keyword(s):  
Brain Tissue ◽  
In Vivo Measurement

scholarly journals Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue

2017 ◽  
Vol 281 ◽  
pp. 1-6 ◽  
Author(s):  
Vassiliy Tsytsarev ◽  
Fatih Akkentli ◽  
Elena Pumbo ◽  
Qinggong Tang ◽  
Yu Chen ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Oxygen Metabolism ◽  
In Vivo Measurement ◽  
Cellular Oxygen ◽  
Implantable Sensor
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