In vivo measurement of regional brain tissue pH using positron emission tomography

1984 ◽  
Vol 15 (S1) ◽  
pp. 98-102 ◽  
Author(s):  
D. A. Rottenberg ◽  
J. Z. Ginos ◽  
K. J. Kearfott ◽  
L. Junck ◽  
D. D. Bigner
Keyword(s):  
Positron Emission Tomography ◽  
Brain Tissue ◽  
Emission Tomography ◽  
Tissue Ph ◽  
In Vivo Measurement ◽  
Regional Brain ◽  
Positron Emission

POSITRON EMISSION TOMOGRAPHY FOR IN-VIVO MEASUREMENT OF REGIONAL BLOOD FLOW, OXYGEN UTILISATION, AND BLOOD VOLUME IN PATIENTS WITH BREAST CARCINOMA

The Lancet ◽  
1984 ◽  
Vol 323 (8369) ◽  
pp. 131-134 ◽  
Author(s):  
RonaldP. Beaney ◽  
Terry Jones ◽  
AdriaanA. Lammertsma ◽  
ChristopherG. Mckenzie ◽  
KeithE. Halnan
Keyword(s):  
Positron Emission Tomography ◽  
Blood Flow ◽  
Breast Carcinoma ◽  
Blood Volume ◽  
Regional Blood Flow ◽  
Emission Tomography ◽  
In Vivo Measurement ◽  
Positron Emission ◽  
Oxygen Utilisation

scholarly journals In vivo Measurement of Regional Cerebral Haematocrit Using Positron Emission Tomography

1984 ◽  
Vol 4 (3) ◽  
pp. 317-322 ◽  
Author(s):  
Adriaan A. Lammertsma ◽  
David J. Brooks ◽  
Ronald P. Beaney ◽  
David R. Turton ◽  
Malcolm J. Kensett ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Mean Value ◽  
Emission Tomography ◽  
Regional Cerebral Blood ◽  
In Vivo Measurement ◽  
Positron Emission ◽  
Regional Cerebral Blood Volume

A method is described for measuring the regional cerebral-to-large vessel haematocrit ratio using inhalation of carbon-11-labelled carbon monoxide and the intravenous injection of carbon-11-labelled methyl-albumin in combination with positron emission tomography. The mean value in a series of nine subjects was 0.69. This is ∼20% lower than the value of 0.85 previously reported. It is concluded that previous measurements of regional cerebral blood volume using a haematocrit ratio of 0.85 will have underestimated the value of regional cerebral blood volume by 20%.

scholarly journals PET and the multitracer concept in the study of neurodegenerative diseases

2015 ◽  
Vol 9 (4) ◽  
pp. 343-349 ◽  
Author(s):  
Henry Engler ◽  
Andres Damian ◽  
Cecilia Bentancourt
Keyword(s):  
Positron Emission Tomography ◽  
Molecular Imaging ◽  
Neurodegenerative Diseases ◽  
Brain Tissue ◽  
Neurodegenerative Disorders ◽  
Clinical Symptoms ◽  
Emission Tomography ◽  
Positron Emission ◽  
The Brain

ABSTRACT The complexity of the pathological reactions of the brain to an aggression caused by an internal or external noxa represents a challenge for molecular imaging. Positron emission tomography (PET) can indicate in vivo,anatomopathological changes involved in the development of different clinical symptoms in patients with neurodegenerative disorders. PET and the multitracer concept can provide information from different systems in the brain tissue building an image of the whole disease. We present here the combination of 18F-flourodeoxyglucose (FDG) and N-[11C-methyl]-L-deuterodeprenyl (DED), FDG and N-[11C-methyl] 2-(4'-methylaminophenyl)-6-hydroxybenzothiazole (PIB), PIB and L-[11C]-3'4-Dihydrophenylalanine (DOPA) and finally PIB and [15O]H2O.

scholarly journals Radiolabeled Cholinesterase Substrates: In Vitro Methods for Determining Structure-Activity Relationships and Identification of a Positron Emission Tomography Radiopharmaceutical for In Vivo Measurement of Butyrylcholinesterase Activity

2001 ◽  
Vol 21 (2) ◽  
pp. 132-143 ◽  
Author(s):  
Scott E. Snyder ◽  
Neeraja Gunupudi ◽  
Phillip S. Sherman ◽  
Elizabeth R. Butch ◽  
Marc B. Skaddan ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Brain Uptake ◽  
In Vivo Measurement ◽  
Structure Activity ◽  
Positron Emission ◽  
Hydrolysis Rates ◽  
Butyrylcholinesterase Activity

There is currently great interest in developing radiolabeled substrates for acetylcholinesterase and butyrylcholinesterase that would be useful in the in vivo imaging of patients with Alzheimer's disease. Using a simple in vitro spectrophotometric assay for determination of enzymatic cleavage rates, the structure-activity relationship for a short series of 1-methyl-4-piperidinyl esters was investigated. Relative enzymatic hydrolysis rates for the well-characterized 1-methyl-4-piperidinyl acetate, propionate, and i-butyrate esters were in agreement with literature values. The 4 and 5 carbon esters of 1-methyl-4-piperidinol were specific for butyrylcholinesterase and cleaved in the rank order n-valerate > n-butyrate >> 2-methylbutyrate, iso-valerate. These spectrophotometric results were also in agreement with in vitro hydrolysis rates in mouse blood and with in vivo regional retention of radioactivity in mouse brain of 11C-labeled analogs. Brain uptake and apparent enzymatic rate constants for 1-[11C]methyl-4-piperidinyl n-butyrate and n-valerate were calculated from in vivo measurements in M. nemistrina using positron emission tomography. Based on higher brain uptake of radioactivity and superior pharmacokinetics, 1-[11C]methyl-4-piperidinyl n-butyrate was identified as a new radiopharmaceutical for the in vivo measurement of butyrylcholinesterase activity.

In Vivo Measurement of Dopamine Receptors in Human Brain by Positron Emission Tomography Age and Sex Differences

1988 ◽  
Vol 515 (1 Central Deter) ◽  
pp. 203-214 ◽  
Author(s):  
DEAN F. WONG ◽  
EMMANUEL P. BROUSSOLLE ◽  
GARY WAND ◽  
VICTOR VILLEMAGNE ◽  
ROBERT F. DANNALS ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Sex Differences ◽  
Human Brain ◽  
Dopamine Receptors ◽  
Emission Tomography ◽  
In Vivo Measurement ◽  
Positron Emission ◽  
Age And Sex
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