Determination of Stem Cell Fate in Planarian Regeneration

2014 ◽  
pp. 71-83 ◽  
Author(s):  
Yoshihiko Umesono
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Stem Cell Fate ◽  
Planarian Regeneration

scholarly journals N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and Epigenetic Player Implicated in Determination of Stem Cell Fate

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Pengfei Ji ◽  
Xia Wang ◽  
Nina Xie ◽  
Yujing Li
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Direct Interaction ◽  
Limited Information ◽  
Stem Cell Fate ◽  
Base Modification ◽  
Dna And Rna ◽  
Proliferation And Differentiation

Vast emerging evidences are linking the base modifications and determination of stem cell fate such as proliferation and differentiation. Among the base modification markers extensively studied, 5-methylcytosine (5-mC) and its oxidative derivatives (5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC), and 5-carboxylcytosine (5-caC)) dynamically occur in DNA and RNA and have been acknowledged as important epigenetic markers involved in regulation of cellular biological processes. N6-Methyladenosine modification in DNA (m6dA), mRNA (m6A), tRNA, and other noncoding RNAs has been defined as another important epigenetic and epitranscriptomic marker in eukaryotes in recent years. The mRNA m6A modification has been characterized biochemically, molecularly, and phenotypically, including elucidation of its methyltransferase complexes (m6A writer), demethylases (m6A eraser), and direct interaction proteins (readers), while limited information on the DNA m6dA is available. The levels and the landscapes of m6A in the epitranscriptomes and epigenomes are precisely and dynamically regulated by the fine-tuned coordination of the writers and erasers in accordance with stages of the growth, development, and reproduction as naturally programmed during the lifespan. Additionally, progress has been made in appreciation of the link between aberrant m6A modification in stem cells and diseases, like cancers and neurodegenerative disorders. These achievements are inspiring scientists to further uncover the epigenetic mechanisms for stem cell development and to dissect pathogenesis of the multiple diseases conferred by development aberration of the stem cells. This review article will highlight the research advances in the role of m6A methylation modifications of DNA and RNA in the regulation of stem cell and genesis of the closely related disorders. Additionally, this article will also address the research directions in the future.

scholarly journals Role of bioinspired polymers in determination of pluripotent stem cell fate

2009 ◽  
Vol 4 (4) ◽  
pp. 561-578 ◽  
Author(s):  
Sheena Abraham ◽  
Nikolai Eroshenko ◽  
Raj R Rao
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Pluripotent Stem Cell ◽  
Stem Cell Fate

scholarly journals Determination of mesenchymal stem cell fate by pigment epithelium‐derived factor (PEDF) results in increased adiposity and reduced bone mineral content

2013 ◽  
Vol 27 (11) ◽  
pp. 4384-4394 ◽  
Author(s):  
Arijeet K. Gattu ◽  
E. Scott Swenson ◽  
Yasuko Iwakiri ◽  
Varman T. Samuel ◽  
Nancy Troiano ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Mineral Content ◽  
Cell Fate ◽  
Bone Mineral ◽  
Mineral Content ◽  
Pigment Epithelium ◽  
Stem Cell Fate ◽  
Pigment Epithelium Derived Factor

scholarly journals JMJD3: a critical epigenetic regulator in stem cell fate

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuanjie Ding ◽  
Yuanchun Yao ◽  
Xingmu Gong ◽  
Qi Zhuo ◽  
Jinhua Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Tumor Development ◽  
Embryonic Stem ◽  
Multipotent Stem Cells ◽  
Stem Cell Fate ◽  
Epigenetic Regulator ◽  
Induced Pluripotent

AbstractThe Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tumor development. There is a comprehensive epigenetic transformation during the transition of embryonic stem cells (ESCs) into specialized cells or the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and MSCs. In this review, we will focus on the recent advances of JMJD3 function in stem cell fate.

scholarly journals The determination of stem cell fate by 3D scaffold structures through the control of cell shape

Biomaterials ◽  
2011 ◽  
Vol 32 (35) ◽  
pp. 9188-9196 ◽  
Author(s):  
Girish Kumar ◽  
Christopher K. Tison ◽  
Kaushik Chatterjee ◽  
P. Scott Pine ◽  
Jennifer H. McDaniel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cell Shape ◽  
3D Scaffold ◽  
Stem Cell Fate
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