Potential Role of Mucosal Addressin Cell Adhesion Molecule-1 in Inflammatory Bowel Diseases

2001 ◽  
pp. 201-204
Author(s):  
Shingo Kato ◽  
Ryota Hokari ◽  
Soichiro Miura
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Inflammatory Bowel Diseases ◽  
Cell Adhesion Molecule ◽  
Potential Role ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Cell Adhesion Molecule 1

CCL25 and CCL28 promote α4β7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow

2008 ◽  
Vol 294 (5) ◽  
pp. G1257-G1267 ◽  
Author(s):  
Alice Miles ◽  
Evaggelia Liaskou ◽  
Bertus Eksteen ◽  
Patricia F. Lalor ◽  
David H. Adams
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Human Lymphocytes ◽  
Adhesion Assay ◽  
Lymphocyte Adhesion ◽  
Chemokine Ligand ◽  
Inflammatory Bowel ◽  
Cell Adhesion Molecule 1

Inflammatory bowel disease is characterized by the recruitment of lymphocytes to the gut via mucosal vessels. Chemokines are believed to trigger α4β1- and α4β7-integrin-mediated adhesion to vascular cell adhesion molecule-1 (VCAM-1) and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) on mucosal vessels, although the contribution of each pathway and the chemokines involved are not well characterized. These interactions occur under conditions of hemodynamic shear, which is critical in determining how lymphocytes integrate chemokine signals to promote transmigration. To define the role of specific chemokines in mediating lymphocyte adhesion to VCAM-1 and MAdCAM-1, we studied the ability of immobilized chemokines to activate adhesion of human lymphocytes in a flow-based adhesion assay. Adhesion to immobilized MAdCAM-1 was α4β7 dependent, with no contribution from α4β1, whereas α4β1 mediated rolling and static adhesion on VCAM-1. Immobilized CC-chemokine ligand (CCL) 25 and CCL28 were both able to trigger α4β7-dependent lymphocyte arrest on MAdCAM-1 under shear, highlighting a potential role for these chemokines in the arrest of lymphocytes on postcapillary venules in the gut. Neither had any effect on adhesion to VCAM-1, suggesting that they selectively trigger α4β7-mediated adhesion. Immobilized CCL21, CCL25, CCL28, and CXC-chemokine ligand (CXCL) 12 all converted rolling adhesion to static arrest on MAdCAM-1 by activating lymphocyte integrins, but only CCL21 and CXCL12 also triggered a motile phenotype characterized by lamelipodia and uropod formation. Thus α4β1/VCAM-1 and α4β7/MAdCAM-1 operate independently to support lymphocyte adhesion from flow, and chemokines may act in concert with one chemokine triggering integrin-mediated arrest and a second chemokine promoting motility and transendothelial migration.

scholarly journals Potential role of SC1, a cell adhesion molecule, in mammary gland tumors

2008 ◽  
Author(s):  
Kenji Hagimori ◽  
Hidenori Kato ◽  
Keiko Fukuda ◽  
Masaharu Kikuta ◽  
Yasuhiro Tsukamoto ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Mammary Gland ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Potential Role ◽  
Mammary Gland Tumors ◽  
A Cell

scholarly journals Evolutionary conserved role of neural cell adhesion molecule-1 in memory

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Vanja Vukojevic ◽  
Pavlina Mastrandreas ◽  
Andreas Arnold ◽  
Fabian Peter ◽  
Iris-T. Kolassa ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Neural Cell Adhesion ◽  
Cell Adhesion Molecule 1

scholarly journals Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases

2009 ◽  
Vol 2009 ◽  
pp. 1-9 ◽  
Author(s):  
Anouk Waeytens ◽  
Martine De Vos ◽  
Debby Laukens
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Potential Role ◽  
Current Knowledge ◽  
Zinc Homeostasis ◽  
Central Position ◽  
Small Proteins ◽  
Immune Mediated ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inflammatory bowel diseases (IBDs) are a group of chronic, relapsing, immune-mediated disorders of the intestine, including Crohn's disease and ulcerative colitis. Recent studies underscore the importance of the damaged epithelial barrier and the dysregulated innate immune system in their pathogenesis. Metallothioneins (MTs) are a family of small proteins with a high and conserved cysteine content that are rapidly upregulated in response to an inflammatory stimulus. Herein, we review the current knowledge regarding the expression and potential role of MTs in IBD. MTs exert a central position in zinc homeostasis, modulate the activation of the transcription factor nuclear factor (NF)-B, and serve as antioxidants. In addition, MTs could be involved in IBD through their antiapoptotic effects or through specific immunomodulating extracellular effects. Reports on MT expression in IBD are contradictory but clearly demonstrate a deviant MT expression supporting the idea that these aberrations in IBD require further clarification.

scholarly journals Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Angiogenesis and Invasion of Human Urinary Bladder Cancer

2004 ◽  
Vol 64 (24) ◽  
pp. 8932-8938 ◽  
Author(s):  
Leticia Oliveira-Ferrer ◽  
Derya Tilki ◽  
Gudrun Ziegeler ◽  
Jessica Hauschild ◽  
Sonja Loges ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Adhesion ◽  
Urinary Bladder ◽  
Carcinoembryonic Antigen ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Urinary Bladder Cancer ◽  
Related Cell ◽  
Cell Adhesion Molecule 1
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