Morphological Changes in the Flow Loaded Canine Carotid Artery

1988 ◽  
pp. 163-169
Author(s):  
H. Masuda ◽  
K. Kawamura ◽  
K. Tohda ◽  
T. Shozawa
Keyword(s):  
Carotid Artery ◽  
Morphological Changes

scholarly journals Skull shape abnormalities in ischemic cerebrovascular and mental diseases in adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masaya Nagaishi ◽  
Yoshiko Fujii ◽  
Yoshiki Sugiura ◽  
Kensuke Suzuki
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Moyamoya Disease ◽  
Internal Carotid ◽  
Morphological Changes ◽  
Head Injuries ◽  
Internal Carotid Artery Stenosis ◽  
Skull Shape ◽  
Mental Diseases ◽  
Cervical Internal Carotid Artery

AbstractMorphological changes in the child skull due to mechanical and metabolic stimulation and synostosis of the suture are well known. On the other hand, few studies have focused on clinical conditions relevant for adult skull deformity. We retrospectively reviewed computed tomography (CT) findings obtained from 365 cases that were treated for head injuries, moyamoya disease, cervical internal carotid artery stenosis, and mental diseases, and investigated the morphological changes in the skull associated with these diseases. The findings from head injuries were used not only for control subjects, but also for the analysis of generational changes in skull shape based on birth year. Head shape had a brachiocephalic tendency with occipital flattening in people born from the 1950s onwards. Cases of moyamoya disease, cervical internal carotid artery stenosis, and mental diseases showed significantly thicker frontal and occipital bone than those of control subjects. The skull thickening was especially noticeable in the frontal bone in moyamoya disease. Plagiocephaly was significantly frequent in moyamoya disease. These uncommon skull shapes are useful CT findings in screening subjects for early evidence of mental diseases and intracranial ischemic diseases with arterial stenosis.

Postischemic Morphological Changes of the Dentate Gyrus in the Gerbil During Reperfusion

2001 ◽  
Vol 7 (S2) ◽  
pp. 658-659
Author(s):  
S.M. Yu ◽  
J.C. Wang
Keyword(s):  
Carotid Artery ◽  
Dentate Gyrus ◽  
Common Carotid Artery ◽  
Morphological Changes ◽  
Membrane Damage ◽  
Immunocytochemical Staining ◽  
Silk Suture ◽  
Pathophysiological Mechanism ◽  
Ischemic Lesion ◽  
Ischemic Period

Postischemic lesion following reperfusion have been investigated in the gerbil by temporary occlusion of a common carotid artery. Two phenomena have been reported in injured ischemic cells: the inability to restore mitochondrial function and evidence of plasma membrane damage. For Further understanding the pathophysiological mechanism of ischemic lesion, we have evaluated the various ischemic period and early postischemic reperfusion. in addition to the morphological changes of the dentate gyrus by light microscopy, we employed the immunocytochemical staining for iNOS and eNOS.The mongolian gerbil, Meriones unguiculatus, were anesthetized with α-chloralose (350mg/kg), bilateral common carotid artery occlusion was induced for 90 minutes. The right common carotid artery was ligated with 5-0 silk suture, and the left was clamped by a micro vascular/miniature aneurysmal clip. After an ischemic period of 90 minutes, restoration of the blood flow of the left common carotid artery was accomplished by withdrawing the microvascular clip.

Morphological Changes in the Carotid Artery Intima after Gastric Bypass for Morbid Obesity

2016 ◽  
Vol 27 (2) ◽  
pp. 357-363 ◽  
Author(s):  
Federico Marchesi ◽  
Roberto Giacosa ◽  
Valeria Reggiani ◽  
Giuseppina De Sario ◽  
Francesco Tartamella ◽  
...  
Keyword(s):  
Morbid Obesity ◽  
Gastric Bypass ◽  
Carotid Artery ◽  
Morphological Changes

Abstract TP93: Early Morphological Changes in Cerebral Arteries of Cerebral Aneurysm Rupture Model Rats

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Hidetsugu Maekawa ◽  
Takeshi Miyamoto ◽  
Keiko T Kitazato ◽  
Kenji Yagi ◽  
Yoshiteru Tada ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Cerebral Aneurysm ◽  
Cerebral Artery ◽  
Morphological Changes ◽  
Cerebral Aneurysms ◽  
Aneurysm Rupture ◽  
Anterior Communicating Artery ◽  
Artery Ligation ◽  
Ruptured Aneurysms ◽  
The Right

Introduction: To study the pathomechanisms of cerebral aneurysms, we developed a rat model of cerebral aneurysm rupture. In order, the ruptured aneurysms were located at the P1 segment of the left posterior cerebral artery, on the anterior cerebral artery (ACA), the right internal carotid artery (ICA), the right middle cerebral artery (MCA), and the anterior communicating artery (AcomA). We investigated the early morphological changes in these arteries that preceded aneurysm formation. Methods: We subjected 10-week-old Sprague-Dawley rats to bilateral ovariectomy and modified carotid artery ligation. They were fed a high salt diet. Two weeks later, the bilateral posterior renal arteries were ligated. Vascular corrosion casts were created 2 weeks after renal artery ligation (n=11) and the morphological features were compared on casts from these- and sham rats (n=3) using a scanning electron microscope. Results: The diameter of the left- was larger than of the right P1 in all rats with hypertension and estrogen deficiency. Endothelial changes were predominantly seen in the AcomA and the left P1. In 5 rats we observed small protrusions without loss of endothelial imprints suggesting local loss of internal elastic lamina in the left P1 where ruptured aneurysms were frequently formed. No aneurysms formed at the right ACA-olfactory artery (OA) bifurcation within 2 weeks after aneurysm induction. None of these changes were found in the controls. As ACA-OA aneurysms were frequently seen at 3 months but never ruptured, the pathophysiology of such, and of aneurysms formed at other sites may be different. Conclusion: We first demonstrate the initial morphological changes that occurred as early as two weeks after aneurysm induction in rats. Early intervention for hypertension and endothelial damage may be beneficial in the management of cerebral aneurysms.

Age-dependent characterization of the carotid and cerebral artery morphologies in a transgenic mouse model of sickle cell anemia using ultrasound and microcomputed tomography

2019 ◽  
Author(s):  
Christian P. Rivera ◽  
Li Li ◽  
Shuangyi Cai ◽  
Nui Pei ◽  
George E. McAlear ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Internal Carotid ◽  
Morphological Changes ◽  
Cerebral Arteries ◽  
Micro Ct ◽  
Arterial Complications ◽  
Middle Cerebral Arteries ◽  
Left And Right

AbstractChildren with sickle cell anemia have elevated stroke risks as well as other arterial complications, but morphological changes to large arteries are not well defined, and the focus has been on the microcirculation where deoxygenation promotes sickling of red blood cells. The goal of this study was to define morphological changes in carotid and cerebral arteries in the Townes transgenic sickle cell mouse model, and to specifically determine anatomical measurement differences in mice homozygous for β-globin S mutation (SS) compared to heterozygous (AS) littermate controls. We used a combination of live imaging with ultrasound and microcomputed tomography (micro-CT) imaging of corrosion casted vessels to quantify arterial dimensions and changes in mice 4, 12, and 24 weeks of age with or without sickle cell anemia. 12 week SS mice had significantly larger common carotid artery diameters than AS mice, and significantly larger diameters in the extracranial and intracranial portions of the internal carotid artery (ICA), determined by ultrasound and micro-CT, respectively. There were also side specific differences between the left and right vessels. There was significant narrowing along ICA length in 12-and 24-week SS mice, decreasing by as much as 70%, such that there was no difference in size between the anterior and middle cerebral arteries, where the ICA terminates, by genotype. Significant narrowing along the length was also measured in the anterior cerebral arteries of 12-and 24-week SS mice, but not AS. Collectively, these findings indicate that sickle cell anemia causes increased arterial dimensions in 12-and 24-week aged mice. We also provide these measurements for the common carotid, internal carotid, anterior cerebral, and middle cerebral arteries for left and right sides, for AS and SS genotypes as a reference for other investigators using in silico modeling of arterial complications caused by aging with sickle cell anemia.

Hemodynamic characteristics of large unruptured internal carotid artery aneurysms prior to rupture: a case control study

2015 ◽  
Vol 8 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Jian Liu ◽  
Jixing Fan ◽  
Jianping Xiang ◽  
Ying Zhang ◽  
Xinjian Yang
Keyword(s):  
Carotid Artery ◽  
Aspect Ratio ◽  
Internal Carotid Artery ◽  
Internal Carotid ◽  
Morphological Changes ◽  
Fluid Dynamic ◽  
Therapeutic Option ◽  
Unruptured Aneurysms ◽  
Ruptured Aneurysms ◽  
Ruptured Intracranial Aneurysm

ObjectivePost-ruptured intracranial aneurysm geometry models have been widely used in computational fluid dynamic studies to assess hemodynamic parameters associated with aneurysm rupture. However, their results may not be valid due to the morphological changes of the aneurysm after rupture. Our aim was to identify the hemodynamic features of aneurysms prior to rupture in comparison with unruptured aneurysms.Materials and methodsWe retrospectively identified three large unruptured internal carotid artery (ICA) aneurysms (pre-ruptured group) with adequate image quality just before rupture. Matched with the same location and similar size, eight unruptured aneurysms (unruptured group) were selected as controls during the same time period. Flow simulations for these aneurysms were performed to compare differences in hemodynamics.ResultsCompared with unruptured aneurysms, pre-ruptured aneurysms had a significantly more irregular aneurysm shape, a higher aspect ratio, and lower aneurysm averaged wall shear stress (WSS) (p=0.024, p=0.048, and p=0.048, respectively). Although pre-ruptured aneurysms had a lower low WSS area and higher Oscillatory Shear Index, these were not statistically significant.ConclusionsFor large unruptured ICA aneurysms, low WSS, higher aspect ratio, and irregular shape were indicators of fatal rupture. Early treatment for such lesions with flow diverter and coils may be the best therapeutic option.

Sign in / Sign up

Export Citation Format

Share Document