Potentially Malignant Disorders of the Oral Cavity

2012 ◽  
pp. 17-32
Author(s):  
David C. Williams ◽  
William T. McGaw
Keyword(s):  
Oral Cavity ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Expression of Interleukin-17 in Potentially Malignant Disorders and Squamous Cell Carcinoma of the Oral Cavity

2018 ◽  
Vol 126 (3) ◽  
pp. e167
Author(s):  
Ricardo Natã Fonseca Silva ◽  
Laís Bueno Dallarmi ◽  
Tarcília Aparecida Silva ◽  
Elismauro Francisco Mendonça ◽  
Aline Carvalho Batista ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Interleukin 17 ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

EVALUATION OF INFLAMMATORY MARKERS IN POTENTIALLY MALIGNANT DISORDERS OF THE ORAL CAVITY

2020 ◽  
Vol 130 (3) ◽  
pp. e276-e277
Author(s):  
RICARDO NATã FONSECA SILVA ◽  
RAíSSA ALBINO DE MATOS ◽  
ANA KAROLINE DE CARVALHO ARAÚJO ◽  
ELISMAURO FRANCISCO DE MENDONÇA ◽  
ALINE CARVALHO BATISTA ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Inflammatory Markers ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals Is there any benefit in surgery for potentially malignant disorders of the oral cavity?

2013 ◽  
Vol 43 (4) ◽  
pp. 239-244 ◽  
Author(s):  
I. Balasundaram ◽  
K. F. B. Payne ◽  
I. Al-Hadad ◽  
M. Alibhai ◽  
S. Thomas ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Frequency and histoclinic pathology of malignant and potentially malignant disorders of oral cavity in Chile

2017 ◽  
Vol 2 ◽  
pp. 1-6
Author(s):  
Juan Pablo Aitken-Saavedra ◽  
Angélica Diaz Valdivia ◽  
Daniela Adorno-Farias ◽  
Andrea Maturana-Ramirez ◽  
Sandra Chaves Tarquinio ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

scholarly journals Immune Checkpoint Inhibitors in Oral Cavity Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: A Systematic Review

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1937 ◽  
Author(s):  
Omar Kujan ◽  
Bede van Schaijik ◽  
Camile S. Farah
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Immune Checkpoint ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Survival Rates ◽  
Oral Potentially Malignant Disorders ◽  
Potentially Malignant Disorders ◽  
Potentially Malignant

Cancers of the oral cavity cause significant cancer-related death worldwide. While survival rates have improved in recent years, new methods of treatment are being investigated to limit disease progression and to improve outcomes, particularly in oral cavity squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). The emerging treatment modality of immunotherapy targets immune checkpoint molecules including PD-1 and its ligand PD-L1, CTLA-4, LAG-3, and TIM-3 to enhance the host immune response against tumours, and to limit the growth and progression of cancer cells. In this systematic review, we searched five databases for keywords pertaining to oral cancers and OPMDs, along with immune checkpoint inhibitors, in order to summarize the current status of their use and efficacy in these diseases. A total of 644 different articles were identified between 2004 and 2019, with 76 deemed suitable for inclusion in the study, providing a total of 8826 samples. Combined results show expression of PD-1 and PD-L1 in the majority of OPMD and OSCC samples, with expression correlating with increased progression and decreased survival rates. Immunotherapy agents pembrolizumab and nivolumab target PD-1 and have been shown to prolong survival rates and improve disease outcomes, especially in combination with chemotherapy or radiotherapy. Despite the equivocal nature of current evidence, there is support for the prognostic and predictive value of immune checkpoint molecules, especially PD-L1, and many studies provide support for the effective use of immune checkpoint inhibitors in the management of OSCC. Limited data is available for OPMD, therefore this should be the focus of future research.

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