Circadian Rhythm of Plasma Gonadotropins, Prolactin and Growth Hormone Levels in Anorexia Nervosa: Correlations with Hypophysial Tests

1981 ◽  
pp. 310-329
Author(s):  
R. Roulier ◽  
B. Conte-Devolx ◽  
E. Castanas ◽  
J. Bert ◽  
J. L. Codaccioni
1973 ◽  
Vol 4 (3) ◽  
pp. 221-227 ◽  
Author(s):  
B.A. McKeown ◽  
T.M. John ◽  
J.C. George

Author(s):  
Jose A. Cabranes ◽  
Isabel Almoguera ◽  
Jose L. Santos ◽  
Isabel Hidalgo ◽  
Maria M. Borque ◽  
...  

1977 ◽  
Vol 85 (4) ◽  
pp. 673-683 ◽  
Author(s):  
Antti Aro ◽  
B.-A. Lamberg ◽  
Risto Pelkonen

ABSTRACT The hypothalamic-pituitary function of 21 women with anorexia nervosa, aged 15–34 years, was studied. The tests included, in addition to the usual tests of thyroid function, a TRH stimulation test with 200 μg of synthetic TRH given iv; the response of serum immunoreactive growth hormone to insulin; and the diurnal variation and response of plasma cortisol to insulin hypoglycaemia. The mean serum TSH level of the patients was higher than that of healthy controls. The mean maximal increment of TSH after TRH was similar in the patients and the controls. However, 18 of the patients but none of the controls showed a delayed TSH-response to TRH, i. e. the TSH-level at 60 min was higher than that recorded 20 min after TRH. Four of the patients had a low free thyroxine index, computed from the PBI and T3 Sephadex uptake values, and 3 of these were clinically hypothyroid. The means for PBI, T4 and the free thyroxine index were all significantly below the means for the controls. The basal serum growth hormone levels were increased in 9 out of 17 patients. In 4 of these an inadequate response to insulin or to glucagon was found. In 5 out of the 8 patients with normal basal growth hormone levels a normal response was found, whereas the remaining 3 showed a subnormal response. The serum growth hormone level was correlated with the degree of weight loss but not with the serum albumin concentration. Plasma cortisol at 08.00 was increased in 9 patients and the diurnal variation was inadequate in 6. Four patients showed a subnormal response to insulin-induced hypoglycaemia, and 2 out of 5 patients tested failed to show adequate suppression of plasma cortisol after 1 mg of dexamethasone. Dysfunction of the hypothalamic-pituitary axis is common in anorexia nervosa. A delayed TSH-response to TRH, compatible with hypothalamic dysfunction, seems to be an almost consistent feature of the disorder, and in some of the patients even clinical hypothalamic hypothyroidism may be evident.


2004 ◽  
Vol 122 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Muneki Tanaka ◽  
Toshihiro Nakahara ◽  
Shinya Kojima ◽  
Tamotsu Nakano ◽  
Tetsuro Muranaga ◽  
...  

1972 ◽  
Vol 70 (2) ◽  
pp. 373-384 ◽  
Author(s):  
W. N. Spellacy ◽  
W. C. Buhi ◽  
S. A. Birk

ABSTRACT Seventy-one women were treated with a daily dose of 0.25 mg of the progestogen ethynodiol diacetate. They were all tested with a three-hour oral glucose tolerance test before beginning the steroid and then again during the sixth month of use. Measurements were made of blood glucose and plasma insulin and growth hormone levels. There was a significant elevation of the blood glucose levels after steroid treatment as well as a deterioration in the tolerance curve in 12.9% of the women. The plasma insulin values were also elevated after drug treatment whereas the fasting ambulatory growth hormone levels did not significantly change. There was a significant association between the changes in glucose and insulin levels and the subject's age, control weight, or weight gain during treatment. The importance of considering the metabolic effects of the progestogen component of oral contraceptives is stressed.


2019 ◽  
Author(s):  
Ultan Healy ◽  
Shoaib Kahn ◽  
Alex Vincent ◽  
Jacinto Martinez ◽  
Christine J H May ◽  
...  

Diabetes ◽  
1976 ◽  
Vol 25 (3) ◽  
pp. 167-172 ◽  
Author(s):  
R. Vigneri ◽  
S. Squatrito ◽  
V. Pezzino ◽  
S. Filetti ◽  
S. Branca ◽  
...  

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