Newer Aspects of Concealed Conduction of the Cardiac Impulse

1978 ◽  
pp. 410-423 ◽  
Author(s):  
Richard Langendorf
Keyword(s):  
Cardiac Impulse

scholarly journals Association of Interatrial Septal Abnormalities with Cardiac Impulse Conduction Disorders in Adult Patients: Experience from a Tertiary Center in Kosovo

2011 ◽  
Vol 6 (1) ◽  
pp. hi.2011.e4 ◽  
Author(s):  
Aurora Bakalli ◽  
Ejup Pllana ◽  
Dardan Koçinaj ◽  
Tefik Bekteshi ◽  
Gani Dragusha ◽  
...  
Keyword(s):  
Adult Patients ◽  
Impulse Conduction ◽  
Conduction Disorders ◽  
Cardiac Impulse ◽  
Tertiary Center ◽  
Patients Experience

scholarly journals Cardiac macrophages prevent sudden death during heart stress

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Junichi Sugita ◽  
Katsuhito Fujiu ◽  
Yukiteru Nakayama ◽  
Takumi Matsubara ◽  
Jun Matsuda ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Sudden Death ◽  
Gap Junctions ◽  
Adrenergic Receptor ◽  
Cardiac Death ◽  
Connexin 43 ◽  
Pressure Overload ◽  
Impulse Conduction ◽  
Cardiac Impulse ◽  
Medical Need

AbstractCardiac arrhythmias are a primary contributor to sudden cardiac death, a major unmet medical need. Because right ventricular (RV) dysfunction increases the risk for sudden cardiac death, we examined responses to RV stress in mice. Among immune cells accumulated in the RV after pressure overload-induced by pulmonary artery banding, interfering with macrophages caused sudden death from severe arrhythmias. We show that cardiac macrophages crucially maintain cardiac impulse conduction by facilitating myocardial intercellular communication through gap junctions. Amphiregulin (AREG) produced by cardiac macrophages is a key mediator that controls connexin 43 phosphorylation and translocation in cardiomyocytes. Deletion of Areg from macrophages led to disorganization of gap junctions and, in turn, lethal arrhythmias during acute stresses, including RV pressure overload and β-adrenergic receptor stimulation. These results suggest that AREG from cardiac resident macrophages is a critical regulator of cardiac impulse conduction and may be a useful therapeutic target for the prevention of sudden death.

Palpable Cardiac Impulse Predicts Adequate Acoustic Windows

2000 ◽  
Vol 17 (1) ◽  
pp. 1-6 ◽  
Author(s):  
JAMES P. EICHELBERGER ◽  
WILLIAM H. PENTZ
Keyword(s):  
Cardiac Impulse

Interaction of Bisoprolol and Procainamide in Human Cardiac Impulse Generation and Conduction

1990 ◽  
Vol 16 ◽  
pp. S193-S195 ◽  
Author(s):  
J. M. Verrostte ◽  
N. M. van Hemel ◽  
J. H. Kingma
Keyword(s):  
Impulse Generation ◽  
Cardiac Impulse

scholarly journals Age-associated Decline in Phosphorylated Connexin 43 Protein Expression in the Left Ventricular Tissue of Wister Rats

2019 ◽  
pp. 1-8
Author(s):  
Donatus Onukwufor Onwuli ◽  
Sandra A. Jones
Keyword(s):  
Left Ventricle ◽  
Western Blot ◽  
Cardiac Arrhythmia ◽  
Connexin 43 ◽  
The Elderly ◽  
Left Ventricular ◽  
Cardiac Impulse ◽  
Ventricular Tissue ◽  
Connexin Proteins ◽  
The Right

Cardiac arrhythmia affects ~ 6% in those over 65 years of age (old), but with 0.2% occurrence in those of 45 years and below (young). Arrhythmia can result from dysregulation of the cardiac impulse generation and its conduction. Connexin proteins are responsible for cardiac impulse conduction, and phosphorylation of connexin 43 determines its functional ability. In this study, Phosphorylated connexin 43, density and expression were assessed in ventricular tissues from young (6 months old) and old (24 months old) Wister rats, using the techniques of western blot and immunohistochemistry. Results show that phosphorylated Cx43 in the left ventricle of 24 months old rats significantly declined (P=0.04 & 0.01) by method of western blot and immunohistochemistry respectively, but did not differ in the right ventricle. The left ventricle is known to be responsible for cardiac output. This data suggest an age-associated decline in the expression of phosphorylated connexin 43 in the left ventricle, which may play a significant role in the development of cardiac arrhythmia in the elderly.

scholarly journals Runaway pacemaker

2019 ◽  
Vol 12 (3) ◽  
pp. e225411
Author(s):  
Ambreen Gul ◽  
Muhammad Asad Sheikh ◽  
Atif Rao
Keyword(s):  
Heart Rate ◽  
Ventricular Tachycardia ◽  
Cardiac Cycle ◽  
Pulse Generator ◽  
Epigastric Pain ◽  
Pacemaker Implantation ◽  
Shortness Of Breath ◽  
Ventricular Pacing ◽  
Cardiac Impulse ◽  
History Of

Runaway pacemaker is phenomenon in which pacemaker induces ventricular tachycardia as a result of some malfunction in the device. This entity is not very common in clinical practice. Normally, the pacemaker perceives the inherent cardiac impulse and hence averting the delivery of pacemaker stimulus in susceptible period of cardiac cycle. This is a case of a pacemaker-induced tachycardia (named as runaway pacemaker) in a patient with a history of Single Chamber Ventricular (VVI) pacemaker. A 75-year-old man was admitted with 3 days history of fluttering in the chest, shortness of breath, central chest and epigastric pain which radiated to the back. His medical history includes pacemaker implantation in 1996 with lead complication following which he was managed with VVI pacemaker, and the last procedure was generator change 4 years ago with no complication. Examination revealed ventricular tachycardia with ECG showing paced rhythm with ventricular pacing at the rate of 200–150/min. His pacemaker-induced ventricular tachycardia was immediately aborted after putting magnet on the device which restored his baseline rhythm with heart rate of 60/min. Pacemaker was explanted urgently with replacement of new pulse generator. The patient was discharged home with VVI pacemaker showing excellent parameters.

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