Accessing carbohydrate-based combinatorial libraries through solid phase and solution phase approaches

1999 ◽  
pp. 41-52 ◽  
Author(s):  
Michael J. Sofia
Keyword(s):  
Solid Phase ◽  
Combinatorial Libraries ◽  
Solution Phase

Screening Solution-Phase Combinatorial Libraries Using Pulsed Ultrafiltration/Electrospray Mass Spectrometry

1997 ◽  
Vol 40 (25) ◽  
pp. 4006-4012 ◽  
Author(s):  
Yong-Zhong Zhao ◽  
Richard B. van Breemen ◽  
Dejan Nikolic ◽  
Chao-Ran Huang ◽  
Charles P. Woodbury ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Combinatorial Libraries ◽  
Solution Phase

scholarly journals Fluorous methods for synthesis and separation of organic molecules

2000 ◽  
Vol 72 (9) ◽  
pp. 1649-1653 ◽  
Author(s):  
Dennis P. Curran
Keyword(s):  
Organic Molecules ◽  
Solid Phase ◽  
Liquid Extraction ◽  
Parallel Synthesis ◽  
Solution Phase ◽  
Phase Extraction ◽  
Organic Reaction ◽  
Reverse Phase ◽  
Liquid Liquid Extraction ◽  
Fluorous Tag

Fluorous molecules partition out of an organic phase and into a fluorous (highly fluorinated) phase in a liquid-liquid extraction. New fluorous techniques allow simple yet substantive separations of organic reaction mixtures based on the presence or absence of a fluorous tag. Fluorous-tagged molecules can also be separated from nontagged molecules by solid phase extraction over fluorous reverse-phase silica gel. This technique is ideal for solution-phase parallel synthesis because it allows simple yet substantive separations of organic reaction mixtures.

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