Mesenchymal Stem Cells for Cardiac Repair: Preclinical Models of Disease

2014 ◽  
pp. 1-19
Author(s):  
Manuel Mazo ◽  
Miriam Araña ◽  
Beatriz Pelacho ◽  
Felipe Prosper
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Repair ◽  
Preclinical Models ◽  
Models Of Disease

scholarly journals Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

2021 ◽  
Vol 22 (5) ◽  
pp. 2269
Author(s):  
Keiji Masuda ◽  
Xu Han ◽  
Hiroki Kato ◽  
Hiroshi Sato ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dental Pulp ◽  
Genetic Disorders ◽  
In Vitro Models ◽  
High Plasticity ◽  
Human Teeth ◽  
Clinical Diagnoses ◽  
Models Of Disease

A subpopulation of mesenchymal stem cells, developmentally derived from multipotent neural crest cells that form multiple facial tissues, resides within the dental pulp of human teeth. These stem cells show high proliferative capacity in vitro and are multipotent, including adipogenic, myogenic, osteogenic, chondrogenic, and neurogenic potential. Teeth containing viable cells are harvested via minimally invasive procedures, based on various clinical diagnoses, but then usually discarded as medical waste, indicating the relatively low ethical considerations to reuse these cells for medical applications. Previous studies have demonstrated that stem cells derived from healthy subjects are an excellent source for cell-based medicine, tissue regeneration, and bioengineering. Furthermore, stem cells donated by patients affected by genetic disorders can serve as in vitro models of disease-specific genetic variants, indicating additional applications of these stem cells with high plasticity. This review discusses the benefits, limitations, and perspectives of patient-derived dental pulp stem cells as alternatives that may complement other excellent, yet incomplete stem cell models, such as induced pluripotent stem cells, together with our recent data.

scholarly journals INCREASED POTENCY OF CARDIAC STEM CELLS COMPARED TO BONE MARROW MESENCHYMAL STEM CELLS IN CARDIAC REPAIR

2011 ◽  
Vol 57 (14) ◽  
pp. E1014
Author(s):  
Behzad Nasehi Oskouei ◽  
Guillaume Lamirault ◽  
Chacko Joseph ◽  
Stephanie Landa ◽  
Marc Dauer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cardiac Repair ◽  
Cardiac Stem Cells ◽  
Marrow Mesenchymal Stem Cells

Allogeneic Mesenchymal Stem Cells in Cellular Cardiomyoplasty: Mechanisms of Cardiac Repair

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Konstantinos Hatzistergos
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Repair ◽  
Cellular Cardiomyoplasty

Abstract 486 Konstantinos E. Hatzistergos, Henry Quevedo, Behzad N. Oskouei, Qinghua Hu, Ramesh Mazhari, Juan P. Zambrano, David Valdes, Gary S. Feigenbaum, Jose R. Rodriguez, Irene S. Margitich, Jeffrey M. Zimmet, Univ of Miami, Miami, FL; Concepción Revilla, INIA, Madrid, Spain; Alan W. Heldman, Ian McNiece, Joshua M. Hare, Univ of Miami, Miami, FL Konstantinos Hatzistergos, 2008 Finalist and Presenting Author

scholarly journals Mesenchymal stem cells and cardiac repair

2008 ◽  
Vol 12 (5b) ◽  
pp. 1795-1810 ◽  
Author(s):  
Catharina Nesselmann ◽  
Nan Ma ◽  
Karen Bieback ◽  
Wolfgang Wagner ◽  
Anthony Ho ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cardiac Repair

scholarly journals Cardiac Repair With a Novel Population of Mesenchymal Stem Cells Resident in the Human Heart

Stem Cells ◽  
2015 ◽  
Vol 33 (10) ◽  
pp. 3100-3113 ◽  
Author(s):  
Yuan Zhang ◽  
Priyadharshini Sivakumaran ◽  
Andrew E. Newcomb ◽  
Damián Hernandez ◽  
Nicole Harris ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Heart ◽  
Cardiac Repair

HYPOXIA MODULATES HUMAN PLACENTA-DERIVED MESENCHYMAL STEM CELLS MIGRATION IN VITRO FOR CARDIAC REPAIR

2016 ◽  
Vol 32 (10) ◽  
pp. S276
Author(s):  
L. Li ◽  
P. Jaiswal ◽  
R. Jurakhan ◽  
K. Selvasandran ◽  
K. Ridwan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Placenta ◽  
Cardiac Repair
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