:
Lung adenocarcinoma (LUAD) is the common histological subtype of non-small-cell
lung carcinoma (NSCLC). Circular RNAs (circRNAs) represent a new class of non-coding RNAs
(ncRNAs) involved in the development of cancer. Accumulating evidence indicated that a large
number of circular RNAs were found to be involved in many biological processes, including tumor
initiation, proliferation and progression. These circRNAs present great potentials as new biomarkers and vital targets for disease diagnosis and prognosis. In this review, we mainly focus on the differentially expressed circRNAs and their functions in the pathogenesis of LUAD, which makes it
possible for the utility of circRNAs as novel biomarkers for early diagnosis and therapy. Especially, it is helpful to develop circRNAs as crucial therapeutic targets, thus providing a promising
biomedical application in the field of cancer gene therapy.
Editorial: Advancing Genomics for Rare Disease Diagnosis and Therapy Development